TR201900213T4 - Bir sürekli hücre kültüründe bir polipeptit veya ilişkin virüsün üretim metodu. - Google Patents
Bir sürekli hücre kültüründe bir polipeptit veya ilişkin virüsün üretim metodu. Download PDFInfo
- Publication number
- TR201900213T4 TR201900213T4 TR2019/00213T TR201900213T TR201900213T4 TR 201900213 T4 TR201900213 T4 TR 201900213T4 TR 2019/00213 T TR2019/00213 T TR 2019/00213T TR 201900213 T TR201900213 T TR 201900213T TR 201900213 T4 TR201900213 T4 TR 201900213T4
- Authority
- TR
- Turkey
- Prior art keywords
- cell culture
- production
- continuous cell
- polypeptide
- related virus
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 4
- 241000700605 Viruses Species 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/006—Cell injection or fusion devices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0056—Xeno-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00051—Methods of production or purification of viral material
- C12N2710/00052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Mevcut buluş memeli hücre kültüründe ilişkin polipeptitler veya virüslerin üretimi için bir sürekli hücre kültürü stratejisiyle ilgilidir. Burada tarif edilen sürekli hücre kültürü stratejisi, kemostat ve perfüzyon kültürü teknolojilerinin avantajlarını birleştirir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23031309P | 2009-07-31 | 2009-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201900213T4 true TR201900213T4 (tr) | 2019-02-21 |
Family
ID=42668436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/00213T TR201900213T4 (tr) | 2009-07-31 | 2010-08-02 | Bir sürekli hücre kültüründe bir polipeptit veya ilişkin virüsün üretim metodu. |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8580554B2 (tr) |
| EP (2) | EP2459697B1 (tr) |
| JP (2) | JP5808742B2 (tr) |
| KR (2) | KR101752789B1 (tr) |
| CN (1) | CN102549142B (tr) |
| AU (1) | AU2010277490B2 (tr) |
| BR (1) | BR112012002137B8 (tr) |
| CA (1) | CA2769354A1 (tr) |
| CO (1) | CO6491119A2 (tr) |
| DK (1) | DK2459697T3 (tr) |
| EA (1) | EA022219B1 (tr) |
| ES (1) | ES2705206T3 (tr) |
| HR (1) | HRP20182165T1 (tr) |
| IN (1) | IN2012DN00899A (tr) |
| MX (2) | MX2012001274A (tr) |
| NZ (1) | NZ597742A (tr) |
| PL (1) | PL2459697T3 (tr) |
| PT (1) | PT2459697T (tr) |
| SG (1) | SG178176A1 (tr) |
| SI (1) | SI2459697T1 (tr) |
| TR (1) | TR201900213T4 (tr) |
| WO (1) | WO2011012725A1 (tr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013000515B1 (pt) | 2010-07-08 | 2021-11-03 | Takeda Pharmaceutical Company Limited | Método para produzir uma composição de fator von willebrand recombinante (rvwf) |
| EP2707387B1 (en) * | 2011-05-13 | 2019-12-25 | Octapharma AG | A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
| PL2726600T3 (pl) | 2011-07-01 | 2017-08-31 | Amgen Inc. | Hodowla ssaczych komórek |
| CN203129697U (zh) | 2013-02-05 | 2013-08-14 | 客贝利(厦门)休闲用品有限公司 | 一种帐篷架杆 |
| CN109097398A (zh) | 2011-11-24 | 2018-12-28 | 吉尼松公司 | 与工业制药应用相容的可放大的慢病毒载体生产系统 |
| US9574167B2 (en) | 2013-02-15 | 2017-02-21 | Pharyx, Inc. | Methods and apparatus for independent control of product and reactant concentrations |
| SG11201506775VA (en) | 2013-03-08 | 2015-09-29 | Genzyme Corp | Continuous purification of therapeutic proteins |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| ES2842350T3 (es) | 2013-03-19 | 2021-07-13 | Cmc Biologics As | Un procedimiento para la producción de un producto (por ejemplo, polipéptido) en un proceso de fermentación de cultivo celular continuo |
| WO2015028546A1 (en) * | 2013-08-30 | 2015-03-05 | Glaxosmithkline Biologicals S.A. | Large scale production of viruses in cell culture |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| AU2015240354A1 (en) | 2014-04-01 | 2016-11-17 | Advantech Bioscience Farmaceutica Ltda. | Stabilization of Factor VIII without calcium as an excipient |
| WO2015149143A2 (en) | 2014-04-01 | 2015-10-08 | Advantech Bioscience Farmacêutica Ltda. | Stable factor viii formulations with low sugar-glycine |
| EP3158055B1 (en) * | 2014-06-13 | 2019-09-11 | CSL Limited | Improved production of recombinant von willebrand factor in a bioreactor |
| CN108884428B (zh) * | 2016-01-26 | 2023-04-11 | 勃林格殷格翰国际公司 | 对连续流动搅拌釜反应器细胞培养系统的连接灌注 |
| SG11201809051YA (en) * | 2016-04-15 | 2018-11-29 | Boehringer Ingelheim Int | Cell retention device and method |
| PL3559203T3 (pl) * | 2016-12-21 | 2021-05-31 | F. Hoffmann-La Roche Ag | Kontrola wzrostu komórek eukariotycznych |
| WO2019239780A1 (ja) * | 2018-06-15 | 2019-12-19 | 富士フイルム株式会社 | 細胞培養方法、細胞培養装置、及び生産物の製造方法 |
| AU2019332764A1 (en) | 2018-08-31 | 2021-05-06 | Genzyme Corporation | Sterile chromatography resin and use thereof in manufacturing processes |
| CN113355297A (zh) * | 2021-06-23 | 2021-09-07 | 吉林冠界生物技术有限公司 | 一种灌流式培养全悬浮mdck细胞生产重组禽流感病毒的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019512A (en) | 1989-03-17 | 1991-05-28 | Baxter International Inc. | Spin filter for removing substantially cell-free culture medium from suspension cell culture system |
| US5626734A (en) | 1995-08-18 | 1997-05-06 | University Technologies International, Inc. | Filter for perfusion cultures of animal cells and the like |
| DE60141908D1 (de) | 2000-10-02 | 2010-06-02 | Novo Nordisk Healthcare Ag | Glykoformen von faktor vii |
| EP1453948A2 (en) * | 2001-11-28 | 2004-09-08 | Sandoz Gmbh | Cell culture process |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| AU2006257073B2 (en) | 2005-06-17 | 2011-08-04 | Children's Medical Center Corporation | ADAMTS13-comprising compositions having thrombolytic activity |
| PL2522717T3 (pl) | 2006-01-04 | 2014-08-29 | Baxalta Inc | Pożywki do hodowli komórkowych wolne od oligopeptydów |
| JP5727790B2 (ja) * | 2007-12-27 | 2015-06-03 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 細胞培養プロセス |
-
2010
- 2010-07-30 US US12/847,921 patent/US8580554B2/en active Active
- 2010-08-02 SI SI201031835T patent/SI2459697T1/sl unknown
- 2010-08-02 KR KR1020127004996A patent/KR101752789B1/ko active IP Right Grant
- 2010-08-02 JP JP2012522190A patent/JP5808742B2/ja active Active
- 2010-08-02 KR KR1020177017512A patent/KR101885046B1/ko active IP Right Grant
- 2010-08-02 CA CA2769354A patent/CA2769354A1/en not_active Abandoned
- 2010-08-02 WO PCT/EP2010/061191 patent/WO2011012725A1/en active Application Filing
- 2010-08-02 AU AU2010277490A patent/AU2010277490B2/en active Active
- 2010-08-02 MX MX2012001274A patent/MX2012001274A/es active IP Right Grant
- 2010-08-02 EP EP10737916.6A patent/EP2459697B1/en active Active
- 2010-08-02 IN IN899DEN2012 patent/IN2012DN00899A/en unknown
- 2010-08-02 PT PT10737916T patent/PT2459697T/pt unknown
- 2010-08-02 PL PL10737916T patent/PL2459697T3/pl unknown
- 2010-08-02 CN CN201080036754.2A patent/CN102549142B/zh active Active
- 2010-08-02 TR TR2019/00213T patent/TR201900213T4/tr unknown
- 2010-08-02 SG SG2012006599A patent/SG178176A1/en unknown
- 2010-08-02 BR BR112012002137A patent/BR112012002137B8/pt active IP Right Grant
- 2010-08-02 DK DK10737916.6T patent/DK2459697T3/en active
- 2010-08-02 EP EP18199855.0A patent/EP3480292A1/en not_active Withdrawn
- 2010-08-02 ES ES10737916T patent/ES2705206T3/es active Active
- 2010-08-02 NZ NZ597742A patent/NZ597742A/en unknown
- 2010-08-02 EA EA201270213A patent/EA022219B1/ru not_active IP Right Cessation
-
2012
- 2012-01-27 MX MX2014008515A patent/MX353610B/es unknown
- 2012-02-06 CO CO12020130A patent/CO6491119A2/es unknown
-
2013
- 2013-10-10 US US14/050,710 patent/US9650612B2/en active Active
-
2015
- 2015-01-14 JP JP2015004718A patent/JP6177260B2/ja active Active
-
2017
- 2017-04-12 US US15/486,181 patent/US10221400B2/en active Active
-
2018
- 2018-12-20 HR HRP20182165TT patent/HRP20182165T1/hr unknown
-
2019
- 2019-01-18 US US16/252,216 patent/US10745672B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR201900213T4 (tr) | Bir sürekli hücre kültüründe bir polipeptit veya ilişkin virüsün üretim metodu. | |
| MY186219A (en) | Production of proteins in glutamine-free cell culture media | |
| EA201492183A1 (ru) | Клетки для получения рекомбинантной идуронат-2-сульфатазы | |
| EA201171018A1 (ru) | Биореактор для культивирования клеток млекопитающих | |
| WO2012045082A3 (en) | Engineered nucleic acids and methods of use thereof | |
| MX2019003427A (es) | Composiciones para cultivo celular y metodos para la produccion de polipeptidos. | |
| TR201910686T4 (tr) | Mrna iletimine yönelik lipit nanopartikül bileşimleri ve yöntemler. | |
| PA8778001A1 (es) | Metodos de produccion de proteinas mediante la utilizacion de compuestos anti-senescencia | |
| EA201391826A1 (ru) | Культивирование клеток млекопитающих | |
| MX356756B (es) | Células madre pluripotentes en microportadores. | |
| MY161866A (en) | Cell culture improvements | |
| AR069956A1 (es) | Procesos para cultivar celulas mamiferas secretoras de proteinas sanguineas heterologas | |
| WO2011075686A3 (en) | Methods & compositions comprising heat shock proteins | |
| EA201492185A1 (ru) | Способ получения рекомбинантной идуронат-2-сульфатазы | |
| EA201590550A1 (ru) | Композиции и способы получения гликопротеинов | |
| BR112014014116A2 (pt) | método de floculação | |
| BR112015022529A2 (pt) | meios de cultura de células e processos de produção de anticorpo | |
| WO2012103496A3 (en) | Expression of soluble viral fusion glycoproteins in mammalian cells | |
| EA201170025A1 (ru) | Способы повышения жизнеспособности и продукции культуры клеток | |
| EP2189529A4 (en) | RECOMBINANT MAMMALIAN CELLS, PROCESS FOR PRODUCING RECOMBINANT MAMMALIAN CELLS, AND METHOD FOR PRODUCING TARGET PROTEIN | |
| EA200900984A1 (ru) | Улучшение клеточного роста | |
| WO2011086447A3 (en) | Fermentation process for the preparation of recombinant heterologous proteins | |
| MX2015010887A (es) | Formulaciones y metodos para aumentar la produccion de proteinas recombinantes. | |
| SG196723A1 (en) | Purification of cell culture derived alpha1 protease inhibitor | |
| EA201201620A1 (ru) | Способ получения рнк-вируса |