EA201170025A1 - Способы повышения жизнеспособности и продукции культуры клеток - Google Patents
Способы повышения жизнеспособности и продукции культуры клетокInfo
- Publication number
- EA201170025A1 EA201170025A1 EA201170025A EA201170025A EA201170025A1 EA 201170025 A1 EA201170025 A1 EA 201170025A1 EA 201170025 A EA201170025 A EA 201170025A EA 201170025 A EA201170025 A EA 201170025A EA 201170025 A1 EA201170025 A1 EA 201170025A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- viability
- increasing
- production
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Описаны способы повышения жизнеспособности и продукции секретируемых белков в подпитываемых культурах эукариотических клеток путем сверхэкспрессии мутанта D300A гена MDM2 в клетках.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6123508P | 2008-06-13 | 2008-06-13 | |
PCT/US2009/047185 WO2009152417A2 (en) | 2008-06-13 | 2009-06-12 | Methods for improving viability and productivity in cell culture |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201170025A1 true EA201170025A1 (ru) | 2011-08-30 |
EA020610B1 EA020610B1 (ru) | 2014-12-30 |
Family
ID=41417407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170025A EA020610B1 (ru) | 2008-06-13 | 2009-06-12 | Способ повышения продукции секретируемого белка в культуре клеток |
Country Status (17)
Country | Link |
---|---|
US (2) | US20100028942A1 (ru) |
EP (1) | EP2300600B1 (ru) |
JP (1) | JP5782375B2 (ru) |
KR (1) | KR101629201B1 (ru) |
CN (1) | CN102083959B (ru) |
AU (2) | AU2009257340A1 (ru) |
BR (1) | BRPI0915156A2 (ru) |
CA (1) | CA2727010C (ru) |
DK (1) | DK2300600T3 (ru) |
EA (1) | EA020610B1 (ru) |
ES (1) | ES2557302T3 (ru) |
IL (1) | IL209617A (ru) |
MX (1) | MX2010013729A (ru) |
SI (1) | SI2300600T1 (ru) |
UA (1) | UA108836C2 (ru) |
WO (1) | WO2009152417A2 (ru) |
ZA (1) | ZA201100328B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103451154B (zh) * | 2012-06-04 | 2015-09-16 | 中国人民解放军军事医学科学院生物工程研究所 | 具有抗凋亡和细胞增殖调控特性的细胞株及其建立方法 |
US20170017891A1 (en) * | 2014-01-30 | 2017-01-19 | Valitacell Limited | A method of predicting relative fed batch production titer of a panel of clonally-derived producer cells |
EP2944958A1 (en) | 2014-04-04 | 2015-11-18 | Techno-Path (Distribution) | A method of predicting phenotypic instability in a cell |
EP3075844A1 (en) | 2015-04-01 | 2016-10-05 | Valitacell Limited | A method of determining a compositional or functional characteristic of a cell culture media |
KR101789509B1 (ko) * | 2015-11-05 | 2017-10-26 | 주식회사 프로젠 | 재조합 인간 갑상선 자극 호르몬을 포함하는 조성물 및 상기 재조합 인간 갑상선 자극 호르몬의 생산 방법 |
KR20180025335A (ko) * | 2016-08-29 | 2018-03-09 | 앱클론(주) | 하이브리도마 개발을 위한 신규 골수종 세포 |
CN114867835A (zh) * | 2019-10-18 | 2022-08-05 | 詹森生物科技公司 | 动态单糖控制方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890716B1 (en) * | 1998-05-07 | 2005-05-10 | Howard Hughes Medical Institute | Recombinant cell line and screening method for identifying agents which regulate apoptosis and tumor suppression |
KR20040044433A (ko) * | 2001-07-10 | 2004-05-28 | 아이덱 파마슈티칼즈 코포레이션 | 세포자멸사 과정의 저해 및 세포 기능의 개선 |
US7273927B2 (en) * | 2003-11-03 | 2007-09-25 | University Of Massachusetts | Mdm2 splice variants |
WO2006111387A2 (en) * | 2005-04-22 | 2006-10-26 | Lonza Biologics Plc. | Mammalian expression vector comprising the mcmv promoter and first intron of hcmv major immediate early gene |
US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
US20100167396A1 (en) | 2006-04-21 | 2010-07-01 | Bayer Healthcare Llc | Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture |
-
2009
- 2009-06-12 EP EP09763705.2A patent/EP2300600B1/en active Active
- 2009-06-12 CA CA2727010A patent/CA2727010C/en not_active Expired - Fee Related
- 2009-06-12 JP JP2011513724A patent/JP5782375B2/ja not_active Expired - Fee Related
- 2009-06-12 BR BRPI0915156A patent/BRPI0915156A2/pt not_active Application Discontinuation
- 2009-06-12 MX MX2010013729A patent/MX2010013729A/es not_active Application Discontinuation
- 2009-06-12 KR KR1020117000620A patent/KR101629201B1/ko active IP Right Grant
- 2009-06-12 CN CN200980123085XA patent/CN102083959B/zh not_active Expired - Fee Related
- 2009-06-12 SI SI200931305T patent/SI2300600T1/sl unknown
- 2009-06-12 WO PCT/US2009/047185 patent/WO2009152417A2/en active Application Filing
- 2009-06-12 ES ES09763705.2T patent/ES2557302T3/es active Active
- 2009-06-12 AU AU2009257340A patent/AU2009257340A1/en not_active Abandoned
- 2009-06-12 EA EA201170025A patent/EA020610B1/ru not_active IP Right Cessation
- 2009-06-12 US US12/483,658 patent/US20100028942A1/en not_active Abandoned
- 2009-06-12 DK DK09763705.2T patent/DK2300600T3/en active
- 2009-12-06 UA UAA201100366A patent/UA108836C2/ru unknown
-
2010
- 2010-11-29 IL IL209617A patent/IL209617A/en active IP Right Grant
-
2011
- 2011-01-12 ZA ZA2011/00328A patent/ZA201100328B/en unknown
- 2011-09-14 US US13/232,462 patent/US8492144B2/en active Active
-
2016
- 2016-03-04 AU AU2016201429A patent/AU2016201429B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2727010A1 (en) | 2009-12-17 |
UA108836C2 (uk) | 2015-06-25 |
AU2009257340A1 (en) | 2009-12-17 |
US8492144B2 (en) | 2013-07-23 |
JP2011524173A (ja) | 2011-09-01 |
ZA201100328B (en) | 2012-06-27 |
CA2727010C (en) | 2017-05-16 |
ES2557302T3 (es) | 2016-01-25 |
MX2010013729A (es) | 2011-01-14 |
DK2300600T3 (en) | 2015-10-12 |
EP2300600A2 (en) | 2011-03-30 |
KR101629201B1 (ko) | 2016-06-10 |
US20120003735A1 (en) | 2012-01-05 |
IL209617A (en) | 2014-07-31 |
EP2300600B1 (en) | 2015-09-30 |
EA020610B1 (ru) | 2014-12-30 |
EP2300600A4 (en) | 2012-07-25 |
CN102083959B (zh) | 2013-08-28 |
KR20110016996A (ko) | 2011-02-18 |
CN102083959A (zh) | 2011-06-01 |
US20100028942A1 (en) | 2010-02-04 |
WO2009152417A3 (en) | 2010-02-18 |
IL209617A0 (en) | 2011-02-28 |
WO2009152417A2 (en) | 2009-12-17 |
BRPI0915156A2 (pt) | 2018-12-11 |
AU2016201429B2 (en) | 2017-10-26 |
SI2300600T1 (sl) | 2015-12-31 |
AU2016201429A1 (en) | 2016-03-24 |
JP5782375B2 (ja) | 2015-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ KG TJ TM |