SI2459697T1 - Metoda proizvodnje polipeptida ali virusa interesa v kontinuirani celični kulturi - Google Patents

Metoda proizvodnje polipeptida ali virusa interesa v kontinuirani celični kulturi

Info

Publication number
SI2459697T1
SI2459697T1 SI201031835T SI201031835T SI2459697T1 SI 2459697 T1 SI2459697 T1 SI 2459697T1 SI 201031835 T SI201031835 T SI 201031835T SI 201031835 T SI201031835 T SI 201031835T SI 2459697 T1 SI2459697 T1 SI 2459697T1
Authority
SI
Slovenia
Prior art keywords
polypeptide
virus
interest
producing
cell culture
Prior art date
Application number
SI201031835T
Other languages
English (en)
Inventor
Leopold Grillberger
Manfred Reiter
Daniel Fleischanderl
Original Assignee
Baxalta GmbH
Baxalta Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH, Baxalta Incorporated filed Critical Baxalta GmbH
Publication of SI2459697T1 publication Critical patent/SI2459697T1/sl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/006Cell injection or fusion devices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0056Xeno-free medium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/98Xeno-free medium and culture conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/00051Methods of production or purification of viral material
    • C12N2710/00052Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
SI201031835T 2009-07-31 2010-08-02 Metoda proizvodnje polipeptida ali virusa interesa v kontinuirani celični kulturi SI2459697T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23031309P 2009-07-31 2009-07-31
PCT/EP2010/061191 WO2011012725A1 (en) 2009-07-31 2010-08-02 Method of producing a polypeptide or virus of interest in a continuous cell culture
EP10737916.6A EP2459697B1 (en) 2009-07-31 2010-08-02 Method of producing a polypeptide or virus of interest in a continuous cell culture

Publications (1)

Publication Number Publication Date
SI2459697T1 true SI2459697T1 (sl) 2019-03-29

Family

ID=42668436

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031835T SI2459697T1 (sl) 2009-07-31 2010-08-02 Metoda proizvodnje polipeptida ali virusa interesa v kontinuirani celični kulturi

Country Status (22)

Country Link
US (4) US8580554B2 (sl)
EP (2) EP3480292A1 (sl)
JP (2) JP5808742B2 (sl)
KR (2) KR101885046B1 (sl)
CN (1) CN102549142B (sl)
AU (1) AU2010277490B2 (sl)
BR (1) BR112012002137B8 (sl)
CA (1) CA2769354A1 (sl)
CO (1) CO6491119A2 (sl)
DK (1) DK2459697T3 (sl)
EA (1) EA022219B1 (sl)
ES (1) ES2705206T3 (sl)
HR (1) HRP20182165T1 (sl)
IN (1) IN2012DN00899A (sl)
MX (2) MX2012001274A (sl)
NZ (1) NZ597742A (sl)
PL (1) PL2459697T3 (sl)
PT (1) PT2459697T (sl)
SG (1) SG178176A1 (sl)
SI (1) SI2459697T1 (sl)
TR (1) TR201900213T4 (sl)
WO (1) WO2011012725A1 (sl)

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JP5953502B2 (ja) 2010-07-08 2016-07-20 バクスアルタ ゲーエムベーハー 細胞培養による組換え型高分子量vWF産生方法
BR112013028006A2 (pt) 2011-05-13 2016-09-06 Octapharma Ag método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii
PT2837680T (pt) 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
CN203129697U (zh) 2013-02-05 2013-08-14 客贝利(厦门)休闲用品有限公司 一种帐篷架杆
RS57066B1 (sr) 2011-11-24 2018-06-29 Genethon Sa industrijskim farmaceutskim primenama kompatibilan skalabilan proizvodni sistem lentiviralnog vektora
US9574167B2 (en) 2013-02-15 2017-02-21 Pharyx, Inc. Methods and apparatus for independent control of product and reactant concentrations
RU2768003C2 (ru) 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US10316282B2 (en) 2013-03-19 2019-06-11 Cmc Biologics A/S Method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process
JP6851827B2 (ja) * 2013-08-30 2021-03-31 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 細胞培養中でのウイルスの大規模製造
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
KR20160146763A (ko) 2014-04-01 2016-12-21 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 부형제로서 칼슘이 첨가되지 않은 factor viii의 안정화
AU2015240353A1 (en) 2014-04-01 2016-11-17 Advantech Bioscience Farmaceutica Ltda. Stable Factor VIII formulations with low sugar-glycine
WO2015188224A1 (en) * 2014-06-13 2015-12-17 Csl Limited Improved production of recombinant von willebrand factor in a bioreactor
CN108884428B (zh) * 2016-01-26 2023-04-11 勃林格殷格翰国际公司 对连续流动搅拌釜反应器细胞培养系统的连接灌注
KR102414290B1 (ko) * 2016-04-15 2022-06-29 베링거 인겔하임 인터내셔날 게엠베하 세포 보유 장치 및 방법
ES2848701T3 (es) * 2016-12-21 2021-08-11 Hoffmann La Roche Control de la proliferación de células eucariotas
WO2019239780A1 (ja) * 2018-06-15 2019-12-19 富士フイルム株式会社 細胞培養方法、細胞培養装置、及び生産物の製造方法
JP2021536353A (ja) 2018-08-31 2021-12-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
CN113355297A (zh) * 2021-06-23 2021-09-07 吉林冠界生物技术有限公司 一种灌流式培养全悬浮mdck细胞生产重组禽流感病毒的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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US5019512A (en) 1989-03-17 1991-05-28 Baxter International Inc. Spin filter for removing substantially cell-free culture medium from suspension cell culture system
US5626734A (en) 1995-08-18 1997-05-06 University Technologies International, Inc. Filter for perfusion cultures of animal cells and the like
DE60137950D1 (de) 2000-10-02 2009-04-23 Novo Nordisk Healthcare Ag Verfahren zur herstellung vitamin-k-abhängiger proteine
US20050069979A1 (en) * 2001-11-28 2005-03-31 Steffen Zeng Cell culture process
US7294484B2 (en) 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
EP1902141B1 (en) 2005-06-17 2012-02-08 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
PL2522717T3 (pl) 2006-01-04 2014-08-29 Baxalta Inc Pożywki do hodowli komórkowych wolne od oligopeptydów
EP3255152A1 (en) * 2007-12-27 2017-12-13 Baxalta GmbH Cell culture processes

Also Published As

Publication number Publication date
NZ597742A (en) 2014-02-28
CO6491119A2 (es) 2012-07-31
BR112012002137B8 (pt) 2020-05-12
DK2459697T3 (en) 2019-01-28
HRP20182165T1 (hr) 2019-03-08
JP2015062436A (ja) 2015-04-09
MX2012001274A (es) 2012-06-01
US20110086411A1 (en) 2011-04-14
US20140038264A1 (en) 2014-02-06
KR101885046B1 (ko) 2018-08-02
CA2769354A1 (en) 2011-02-03
SG178176A1 (en) 2012-03-29
US20180051261A1 (en) 2018-02-22
EP3480292A1 (en) 2019-05-08
BR112012002137A2 (pt) 2015-09-15
US9650612B2 (en) 2017-05-16
WO2011012725A1 (en) 2011-02-03
EP2459697A1 (en) 2012-06-06
BR112012002137B1 (pt) 2020-04-14
JP6177260B2 (ja) 2017-08-09
US10221400B2 (en) 2019-03-05
EA201270213A1 (ru) 2012-06-29
EP2459697B1 (en) 2018-10-17
CN102549142B (zh) 2014-07-16
JP5808742B2 (ja) 2015-11-10
KR20170077286A (ko) 2017-07-05
PT2459697T (pt) 2019-01-21
US8580554B2 (en) 2013-11-12
US20190153400A1 (en) 2019-05-23
MX353610B (es) 2018-01-18
US10745672B2 (en) 2020-08-18
KR20120038531A (ko) 2012-04-23
AU2010277490A1 (en) 2012-02-09
WO2011012725A8 (en) 2011-05-05
JP2013500710A (ja) 2013-01-10
AU2010277490B2 (en) 2014-08-28
ES2705206T3 (es) 2019-03-22
EA022219B1 (ru) 2015-11-30
PL2459697T3 (pl) 2019-04-30
TR201900213T4 (tr) 2019-02-21
IN2012DN00899A (sl) 2015-04-03
KR101752789B1 (ko) 2017-06-30
CN102549142A (zh) 2012-07-04

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