PL368068A1 - Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent - Google Patents

Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent

Info

Publication number
PL368068A1
PL368068A1 PL02368068A PL36806802A PL368068A1 PL 368068 A1 PL368068 A1 PL 368068A1 PL 02368068 A PL02368068 A PL 02368068A PL 36806802 A PL36806802 A PL 36806802A PL 368068 A1 PL368068 A1 PL 368068A1
Authority
PL
Poland
Prior art keywords
methyl
combination
benzoylamido
piperazino
methylphenyl
Prior art date
Application number
PL02368068A
Other languages
English (en)
Polish (pl)
Inventor
Christian Bruns
Elisabeth Buchdunger
Terence O'reilly
Sandra Leta Silberman
Markus Wartmann
Gisbert Weckbecker
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL368068A1 publication Critical patent/PL368068A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
PL02368068A 2001-05-16 2002-05-15 Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent PL368068A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29142701P 2001-05-16 2001-05-16
PCT/EP2002/005362 WO2002092091A1 (en) 2001-05-16 2002-05-15 Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent

Publications (1)

Publication Number Publication Date
PL368068A1 true PL368068A1 (en) 2005-03-21

Family

ID=23120246

Family Applications (2)

Application Number Title Priority Date Filing Date
PL02368068A PL368068A1 (en) 2001-05-16 2002-05-15 Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
PL392652A PL392652A1 (pl) 2001-05-16 2002-05-15 Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL392652A PL392652A1 (pl) 2001-05-16 2002-05-15 Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację

Country Status (27)

Country Link
US (3) US20040167134A1 (enExample)
EP (2) EP1392313B1 (enExample)
JP (2) JP4477303B2 (enExample)
KR (2) KR20080091866A (enExample)
CN (1) CN1700917B (enExample)
AT (1) ATE359790T1 (enExample)
AU (1) AU2002342335B2 (enExample)
BR (1) BR0209647A (enExample)
CA (1) CA2444867C (enExample)
CO (1) CO5540315A2 (enExample)
CZ (1) CZ299756B6 (enExample)
DE (1) DE60219617T2 (enExample)
DK (1) DK1392313T3 (enExample)
EC (1) ECSP034823A (enExample)
ES (1) ES2283570T3 (enExample)
HU (1) HUP0400038A3 (enExample)
IL (1) IL158274A0 (enExample)
MX (1) MXPA03010401A (enExample)
NO (2) NO325453B1 (enExample)
NZ (1) NZ529145A (enExample)
PL (2) PL368068A1 (enExample)
PT (1) PT1392313E (enExample)
RU (1) RU2318517C2 (enExample)
SI (1) SI1392313T1 (enExample)
SK (1) SK14042003A3 (enExample)
WO (1) WO2002092091A1 (enExample)
ZA (1) ZA200307665B (enExample)

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JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
US9334239B2 (en) 2012-12-21 2016-05-10 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
MX368099B (es) 2013-05-14 2019-09-19 Eisai R&D Man Co Ltd Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
JP6659554B2 (ja) 2014-08-28 2020-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 高純度キノリン誘導体およびその製造方法
HUE064614T2 (hu) 2015-02-25 2024-04-28 Eisai R&D Man Co Ltd Eljárás egy kinolin-származék keserû ízének elnyomására
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
BR112017027227B1 (pt) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd Agente anti-câncer
JP6553726B2 (ja) 2015-08-20 2019-07-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療剤
KR102539920B1 (ko) 2017-02-08 2023-06-05 에자이 알앤드디 매니지먼트 가부시키가이샤 종양-치료용 약제학적 조성물
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Also Published As

Publication number Publication date
ATE359790T1 (de) 2007-05-15
HK1062895A1 (en) 2004-12-03
DE60219617D1 (de) 2007-05-31
CN1700917A (zh) 2005-11-23
JP4477303B2 (ja) 2010-06-09
DK1392313T3 (da) 2007-06-25
EP2253319A1 (en) 2010-11-24
CA2444867A1 (en) 2002-11-21
US20120283206A1 (en) 2012-11-08
RU2318517C2 (ru) 2008-03-10
MXPA03010401A (es) 2004-03-09
SI1392313T1 (sl) 2007-08-31
JP2010059202A (ja) 2010-03-18
AU2002342335B2 (en) 2006-02-02
IL158274A0 (en) 2004-05-12
CA2444867C (en) 2010-08-17
NO20034713D0 (no) 2003-10-21
HUP0400038A3 (en) 2007-05-29
NO325453B1 (no) 2008-05-05
PT1392313E (pt) 2007-07-17
PL392652A1 (pl) 2010-12-06
NO20034713L (no) 2003-10-21
ES2283570T3 (es) 2007-11-01
EP1392313A1 (en) 2004-03-03
JP2004531549A (ja) 2004-10-14
NZ529145A (en) 2005-07-29
HUP0400038A2 (hu) 2004-04-28
WO2002092091A1 (en) 2002-11-21
ZA200307665B (en) 2004-04-21
US20040167134A1 (en) 2004-08-26
BR0209647A (pt) 2004-07-27
CO5540315A2 (es) 2005-07-29
DE60219617T2 (de) 2008-01-03
SK14042003A3 (sk) 2004-05-04
KR20030094415A (ko) 2003-12-11
RU2003135786A (ru) 2005-02-27
CZ20033098A3 (cs) 2004-02-18
US20090202541A1 (en) 2009-08-13
KR20080091866A (ko) 2008-10-14
ECSP034823A (es) 2003-12-24
CZ299756B6 (cs) 2008-11-12
CN1700917B (zh) 2010-04-28
NO20076323L (no) 2007-12-07
EP1392313B1 (en) 2007-04-18

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