RU2318517C2 - Комбинация, включающая n-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамин и химиотерапевтический агент - Google Patents

Комбинация, включающая n-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамин и химиотерапевтический агент Download PDF

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RU2318517C2
RU2318517C2 RU2003135786/14A RU2003135786A RU2318517C2 RU 2318517 C2 RU2318517 C2 RU 2318517C2 RU 2003135786/14 A RU2003135786/14 A RU 2003135786/14A RU 2003135786 A RU2003135786 A RU 2003135786A RU 2318517 C2 RU2318517 C2 RU 2318517C2
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combination
dose
patients
treatment
administered
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RU2003135786A (ru
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Кристиан Брунс
Элизабет БУХДУНГЕР
Теренс О`РЕЙЛЛИ
Сандра Лита СИЛБЕРМАН
Маркус ВАРТМАНН
Гизберт ВЕККБЕККЕР
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Новартис Аг
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
RU2003135786/14A 2001-05-16 2002-05-15 Комбинация, включающая n-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамин и химиотерапевтический агент RU2318517C2 (ru)

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US29142701P 2001-05-16 2001-05-16
US60/291,427 2001-05-16

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RU2003135786A RU2003135786A (ru) 2005-02-27
RU2318517C2 true RU2318517C2 (ru) 2008-03-10

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CN101848895B (zh) * 2007-11-09 2013-10-23 卫材R&D管理有限公司 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
JP5399926B2 (ja) * 2008-01-29 2014-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管阻害物質とタキサンとの併用
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RU2580609C2 (ru) 2011-04-18 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
AU2013364953A1 (en) 2012-12-21 2015-04-30 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
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KR102329681B1 (ko) 2014-08-28 2021-11-23 에자이 알앤드디 매니지먼트 가부시키가이샤 고순도의 퀴놀린 유도체 및 이를 제조하는 방법
KR20250024102A (ko) 2015-02-25 2025-02-18 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 고미 억제 방법
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PT1392313E (pt) 2007-07-17
BR0209647A (pt) 2004-07-27
CZ299756B6 (cs) 2008-11-12
US20090202541A1 (en) 2009-08-13
CA2444867A1 (en) 2002-11-21
NO20034713D0 (no) 2003-10-21
JP2004531549A (ja) 2004-10-14
JP2010059202A (ja) 2010-03-18
EP2253319A1 (en) 2010-11-24
PL392652A1 (pl) 2010-12-06
KR20080091866A (ko) 2008-10-14
US20040167134A1 (en) 2004-08-26
WO2002092091A1 (en) 2002-11-21
CA2444867C (en) 2010-08-17
KR20030094415A (ko) 2003-12-11
ZA200307665B (en) 2004-04-21
EP1392313B1 (en) 2007-04-18
CN1700917B (zh) 2010-04-28
RU2003135786A (ru) 2005-02-27
CZ20033098A3 (cs) 2004-02-18
NO325453B1 (no) 2008-05-05
IL158274A0 (en) 2004-05-12
US20120283206A1 (en) 2012-11-08
HUP0400038A3 (en) 2007-05-29
CN1700917A (zh) 2005-11-23
ES2283570T3 (es) 2007-11-01
SK14042003A3 (sk) 2004-05-04
HUP0400038A2 (hu) 2004-04-28
NO20076323L (no) 2007-12-07
PL368068A1 (en) 2005-03-21
NO20034713L (no) 2003-10-21
DE60219617D1 (de) 2007-05-31
ATE359790T1 (de) 2007-05-15
HK1062895A1 (en) 2004-12-03
MXPA03010401A (es) 2004-03-09
SI1392313T1 (sl) 2007-08-31
DK1392313T3 (da) 2007-06-25
DE60219617T2 (de) 2008-01-03
EP1392313A1 (en) 2004-03-03
AU2002342335B2 (en) 2006-02-02
NZ529145A (en) 2005-07-29
ECSP034823A (es) 2003-12-24
JP4477303B2 (ja) 2010-06-09
CO5540315A2 (es) 2005-07-29

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