ECSP034823A - Combinación que comprende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina, y un agente quimioterapéutico - Google Patents

Combinación que comprende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina, y un agente quimioterapéutico

Info

Publication number
ECSP034823A
ECSP034823A EC2003004823A ECSP034823A ECSP034823A EC SP034823 A ECSP034823 A EC SP034823A EC 2003004823 A EC2003004823 A EC 2003004823A EC SP034823 A ECSP034823 A EC SP034823A EC SP034823 A ECSP034823 A EC SP034823A
Authority
EC
Ecuador
Prior art keywords
methyl
combination
piperazino
amine
chemotherapeutic agent
Prior art date
Application number
EC2003004823A
Other languages
English (en)
Inventor
Gisbert Weckbecker
Christian Bruns
Markus Wartmann
Terence O'reilly
Sandra Leta Silberman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034823A publication Critical patent/ECSP034823A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un método para el tratamiento de un animal de sangre caliente, en especial un ser humano, que tiene una enfermedad proliferativa o rechazo de trasplante agudo o crónico, el cual comprende administrar al animal una combinación que comprende: (a) N-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina, y (b) un agente quimioterapéutico seleccionado a partir de agentes antineoplásticos, en especial como se definen en la presente, y agentes efectivos en el tratamiento de rechazo de trasplante agudo o crónico; una combinación que comprende (a) y (b) como se definen anteriormente, y opcionalmente cuando menos un vehículo farmacéuticamente aceptable para su uso simultáneo, separado, o en secuencia, en particular para la demora de progreso o tratamiento de una enfermedad proliferativa, en especial una enfermedad de tumor sólido.
EC2003004823A 2001-05-16 2003-10-29 Combinación que comprende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina, y un agente quimioterapéutico ECSP034823A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29142701P 2001-05-16 2001-05-16

Publications (1)

Publication Number Publication Date
ECSP034823A true ECSP034823A (es) 2003-12-24

Family

ID=23120246

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004823A ECSP034823A (es) 2001-05-16 2003-10-29 Combinación que comprende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina, y un agente quimioterapéutico

Country Status (28)

Country Link
US (3) US20040167134A1 (es)
EP (2) EP2253319A1 (es)
JP (2) JP4477303B2 (es)
KR (2) KR20080091866A (es)
CN (1) CN1700917B (es)
AT (1) ATE359790T1 (es)
AU (1) AU2002342335B2 (es)
BR (1) BR0209647A (es)
CA (1) CA2444867C (es)
CO (1) CO5540315A2 (es)
CZ (1) CZ299756B6 (es)
DE (1) DE60219617T2 (es)
DK (1) DK1392313T3 (es)
EC (1) ECSP034823A (es)
ES (1) ES2283570T3 (es)
HK (1) HK1062895A1 (es)
HU (1) HUP0400038A3 (es)
IL (1) IL158274A0 (es)
MX (1) MXPA03010401A (es)
NO (2) NO325453B1 (es)
NZ (1) NZ529145A (es)
PL (2) PL392652A1 (es)
PT (1) PT1392313E (es)
RU (1) RU2318517C2 (es)
SI (1) SI1392313T1 (es)
SK (1) SK14042003A3 (es)
WO (1) WO2002092091A1 (es)
ZA (1) ZA200307665B (es)

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ES2841809T3 (es) 2011-06-03 2021-07-09 Eisai R&D Man Co Ltd Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
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Also Published As

Publication number Publication date
US20090202541A1 (en) 2009-08-13
KR20030094415A (ko) 2003-12-11
SK14042003A3 (sk) 2004-05-04
PL368068A1 (en) 2005-03-21
IL158274A0 (en) 2004-05-12
JP2004531549A (ja) 2004-10-14
JP2010059202A (ja) 2010-03-18
NO20034713D0 (no) 2003-10-21
CA2444867A1 (en) 2002-11-21
US20040167134A1 (en) 2004-08-26
CO5540315A2 (es) 2005-07-29
CZ299756B6 (cs) 2008-11-12
AU2002342335B2 (en) 2006-02-02
HUP0400038A2 (hu) 2004-04-28
EP1392313B1 (en) 2007-04-18
HK1062895A1 (en) 2004-12-03
ES2283570T3 (es) 2007-11-01
HUP0400038A3 (en) 2007-05-29
JP4477303B2 (ja) 2010-06-09
DE60219617T2 (de) 2008-01-03
WO2002092091A1 (en) 2002-11-21
MXPA03010401A (es) 2004-03-09
SI1392313T1 (sl) 2007-08-31
CZ20033098A3 (cs) 2004-02-18
DE60219617D1 (de) 2007-05-31
BR0209647A (pt) 2004-07-27
CA2444867C (en) 2010-08-17
EP1392313A1 (en) 2004-03-03
NZ529145A (en) 2005-07-29
DK1392313T3 (da) 2007-06-25
ZA200307665B (en) 2004-04-21
KR20080091866A (ko) 2008-10-14
PL392652A1 (pl) 2010-12-06
PT1392313E (pt) 2007-07-17
EP2253319A1 (en) 2010-11-24
NO20076323L (no) 2007-12-07
CN1700917A (zh) 2005-11-23
US20120283206A1 (en) 2012-11-08
NO325453B1 (no) 2008-05-05
CN1700917B (zh) 2010-04-28
NO20034713L (no) 2003-10-21
RU2003135786A (ru) 2005-02-27
ATE359790T1 (de) 2007-05-15
RU2318517C2 (ru) 2008-03-10

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