CN1700917B - 含n-(5-{4-[4-甲基-(1-哌嗪基)甲基]-苯甲酰氨基}-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶-胺和化疗药的联合形式 - Google Patents

含n-(5-{4-[4-甲基-(1-哌嗪基)甲基]-苯甲酰氨基}-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶-胺和化疗药的联合形式 Download PDF

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Publication number
CN1700917B
CN1700917B CN028093623A CN02809362A CN1700917B CN 1700917 B CN1700917 B CN 1700917B CN 028093623 A CN028093623 A CN 028093623A CN 02809362 A CN02809362 A CN 02809362A CN 1700917 B CN1700917 B CN 1700917B
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administration
patient
methyl
combination
dosage
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CN1700917A (zh
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C·布伦斯
E·布赫东格尔
T·奥赖利
S·L·西尔贝曼
M·瓦特曼
G·韦克贝克
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
CN028093623A 2001-05-16 2002-05-15 含n-(5-{4-[4-甲基-(1-哌嗪基)甲基]-苯甲酰氨基}-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶-胺和化疗药的联合形式 Expired - Fee Related CN1700917B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29142701P 2001-05-16 2001-05-16
US60/291,427 2001-05-16
PCT/EP2002/005362 WO2002092091A1 (en) 2001-05-16 2002-05-15 Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent

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CN1700917A CN1700917A (zh) 2005-11-23
CN1700917B true CN1700917B (zh) 2010-04-28

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EP1392313B1 (en) 2007-04-18
WO2002092091A1 (en) 2002-11-21
NO20034713L (no) 2003-10-21
MXPA03010401A (es) 2004-03-09
SI1392313T1 (sl) 2007-08-31
ZA200307665B (en) 2004-04-21
RU2318517C2 (ru) 2008-03-10
CZ299756B6 (cs) 2008-11-12
DE60219617T2 (de) 2008-01-03
US20090202541A1 (en) 2009-08-13
AU2002342335B2 (en) 2006-02-02
JP4477303B2 (ja) 2010-06-09
NO20034713D0 (no) 2003-10-21
HUP0400038A2 (hu) 2004-04-28
ES2283570T3 (es) 2007-11-01
ATE359790T1 (de) 2007-05-15
HUP0400038A3 (en) 2007-05-29
NO325453B1 (no) 2008-05-05
NZ529145A (en) 2005-07-29
CN1700917A (zh) 2005-11-23
EP2253319A1 (en) 2010-11-24
NO20076323L (no) 2007-12-07
KR20030094415A (ko) 2003-12-11
PT1392313E (pt) 2007-07-17
CO5540315A2 (es) 2005-07-29
JP2004531549A (ja) 2004-10-14
IL158274A0 (en) 2004-05-12
PL368068A1 (en) 2005-03-21
PL392652A1 (pl) 2010-12-06
DE60219617D1 (de) 2007-05-31
ECSP034823A (es) 2003-12-24
EP1392313A1 (en) 2004-03-03
CZ20033098A3 (cs) 2004-02-18
CA2444867A1 (en) 2002-11-21
HK1062895A1 (en) 2004-12-03
US20120283206A1 (en) 2012-11-08
CA2444867C (en) 2010-08-17
KR20080091866A (ko) 2008-10-14
DK1392313T3 (da) 2007-06-25
SK14042003A3 (sk) 2004-05-04
RU2003135786A (ru) 2005-02-27
BR0209647A (pt) 2004-07-27
US20040167134A1 (en) 2004-08-26
JP2010059202A (ja) 2010-03-18

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