PL2573068T3 - Sposób otrzymywania związków pośrednich użytecznych jako modulatory receptora opioidowego - Google Patents
Sposób otrzymywania związków pośrednich użytecznych jako modulatory receptora opioidowegoInfo
- Publication number
- PL2573068T3 PL2573068T3 PL12194058T PL12194058T PL2573068T3 PL 2573068 T3 PL2573068 T3 PL 2573068T3 PL 12194058 T PL12194058 T PL 12194058T PL 12194058 T PL12194058 T PL 12194058T PL 2573068 T3 PL2573068 T3 PL 2573068T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds useful
- opioid receptor
- receptor modulators
- preparing intermediates
- intermediates
- Prior art date
Links
- 102000003840 Opioid Receptors Human genes 0.000 title 1
- 108090000137 Opioid Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Amplitude Modulation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Eye Examination Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55334204P | 2004-03-15 | 2004-03-15 | |
| EP10182349.0A EP2298744B1 (en) | 2004-03-15 | 2005-03-14 | Opioid receptor modulators |
| EP12194058.9A EP2573068B9 (en) | 2004-03-15 | 2005-03-14 | Process for preparing intermediates of compounds useful as opioid receptor modulators |
| EP05728171A EP1725537B1 (en) | 2004-03-15 | 2005-03-14 | Novel compounds as opioid receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2573068T3 true PL2573068T3 (pl) | 2015-06-30 |
Family
ID=34962827
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12194058T PL2573068T3 (pl) | 2004-03-15 | 2005-03-14 | Sposób otrzymywania związków pośrednich użytecznych jako modulatory receptora opioidowego |
| PL13173454T PL2653465T3 (pl) | 2004-03-15 | 2005-03-14 | Modulatory receptora opioidowego |
| PL05728171T PL1725537T3 (pl) | 2004-03-15 | 2005-03-14 | Nowe związki jako modulatory receptorów opioidowych |
| PL10182349T PL2298744T3 (pl) | 2004-03-15 | 2005-03-14 | Modulatory receptora opioidowego |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13173454T PL2653465T3 (pl) | 2004-03-15 | 2005-03-14 | Modulatory receptora opioidowego |
| PL05728171T PL1725537T3 (pl) | 2004-03-15 | 2005-03-14 | Nowe związki jako modulatory receptorów opioidowych |
| PL10182349T PL2298744T3 (pl) | 2004-03-15 | 2005-03-14 | Modulatory receptora opioidowego |
Country Status (35)
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| RS54199B1 (sr) * | 2004-03-15 | 2015-12-31 | Janssen Pharmaceutica Nv | Postupak za dobijanje intermedijera jedinjenja korisnih kao modulatori opioidnih receptora |
| NZ551288A (en) | 2004-05-14 | 2010-10-29 | Janssen Pharmaceutica Nv | Carboxamido opioid compounds that are derivatives of tramadol |
| TW200635607A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized Aβ antibodies for use in improving cognition |
| EA014366B1 (ru) * | 2005-03-14 | 2010-10-29 | Янссен Фармацевтика, Н.В. | Способ получения опиоидных модуляторов |
| EA014245B1 (ru) * | 2005-12-14 | 2010-10-29 | Бристол-Маерс Сквибб Компани | Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве ингибиторов фактора xia |
| CN101336229B (zh) | 2005-12-23 | 2012-06-13 | 西兰岛药物有限公司 | 改性的拟赖氨酸化合物 |
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US20080188545A1 (en) | 2006-12-21 | 2008-08-07 | Alimardanov Asaf R | Synthesis of pyrrolidine compounds |
| EP2176234B1 (en) | 2007-07-09 | 2016-01-27 | Forest Tosara Limited | Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy- benzoic acid |
| DK2182983T3 (da) | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之ｌ－丙胺酸衍生物之方法 |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| JP5198220B2 (ja) * | 2008-11-13 | 2013-05-15 | 東ソ−・エフテック株式会社 | アミノ酸誘導体の製造方法 |
| CA2748765C (en) | 2009-07-06 | 2014-07-22 | Akebia Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| CA2836311A1 (en) | 2011-05-16 | 2012-11-22 | Bionomics Limited | Amine derivatives as potassium channel blockers |
| EP2524912A1 (en) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
| EP3505182A1 (en) | 2011-10-13 | 2019-07-03 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9675587B2 (en) * | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| US9447079B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| SI2970132T1 (sl) | 2013-03-14 | 2021-02-26 | Epizyme, Inc. | Inhibitorji argininmetiltransferaze in njihove uporabe |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| IS2977B (is) | 2015-02-23 | 2017-07-15 | Actavis Group Ptc Ehf. | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
| EP3319444B1 (en) | 2015-07-09 | 2022-03-09 | The Regents of the University of California | Mu opioid receptor modulators |
| EP3325450A1 (en) | 2015-07-23 | 2018-05-30 | Teva Pharmaceuticals International GmbH | Solid state forms of eluxadoline |
| JPWO2017043626A1 (ja) * | 2015-09-11 | 2018-06-21 | 株式会社カネカ | 光学活性４−カルバモイル−２，６−ジメチルフェニルアラニン誘導体の製造法 |
| MX387804B (es) | 2015-09-23 | 2025-03-19 | Aerpio Therapeutics Inc | Metodos para tratar presion intraocular con activadores de tie-2 |
| CN105250232B (zh) * | 2015-09-29 | 2018-08-14 | 江苏汇智知识产权服务有限公司 | 一种伊卢多啉肠溶片及其制备方法 |
| WO2017114446A1 (zh) * | 2015-12-31 | 2017-07-06 | 苏州晶云药物科技有限公司 | 艾沙度林的新晶型及其制备方法 |
| EP3272741A1 (en) | 2016-07-21 | 2018-01-24 | Euticals S.P.A. | New stable solvate crystalline forms of eluxadoline |
| CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
| CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
| US20190177281A1 (en) * | 2016-05-03 | 2019-06-13 | Sromovasam THIRUMALAI RAJAN | Process for the preparation of 5-[[[(2s)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl] [(1s)-1-(4-phenyl-1h-imidazol-2-yl)ethyl]amino] methyl-2-methoxybenzoic acid and its polymorphs thereof |
| MA45184A (fr) * | 2016-05-30 | 2019-04-10 | Sun Pharmaceutical Ind Ltd | Procédé de préparation de l'éluxadoline . |
| EP3474847B1 (en) * | 2016-06-23 | 2022-09-07 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
| WO2018020450A2 (en) | 2016-07-28 | 2018-02-01 | Lupin Limited | Process for the preparation of eluxadoline |
| CZ2016548A3 (cs) | 2016-09-07 | 2018-03-14 | Zentiva, K.S. | Pevné formy eluxadolinu |
| WO2018047131A1 (en) * | 2016-09-09 | 2018-03-15 | Sun Pharmaceutical Industries Limited | Amorphous eluxadoline |
| US10479769B2 (en) | 2016-09-20 | 2019-11-19 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
| WO2018138272A1 (en) | 2017-01-27 | 2018-08-02 | Quimica Sintetica, S. A. | Eluxadoline crystalline form and process for the preparation thereof |
| WO2018138274A1 (en) | 2017-01-27 | 2018-08-02 | Quimica Sintetica, S. A. | Eluxadoline crystalline forms and processes for their preparation |
| US11324799B2 (en) | 2017-05-05 | 2022-05-10 | Zealand Pharma A/S | Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease |
| WO2019008604A1 (en) | 2017-07-07 | 2019-01-10 | Cipla Limited | NEW FORMS OF MU-OPIOID RECEPTOR AGONIST |
| WO2019144805A1 (zh) * | 2018-01-25 | 2019-08-01 | 四川科伦博泰生物医药股份有限公司 | 取代的苯乙胺化合物及其制备方法和用途 |
| WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
| CA3109557A1 (en) | 2018-08-20 | 2020-02-27 | Allergan Holdings Unlimited Company | Polymorphs of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
| EP3856245A4 (en) | 2018-09-24 | 2022-10-26 | EyePoint Pharmaceuticals, Inc. | MULTISPECIFIC ANTIBODIES THAT TARGET HPTP - ß (VE-PTP) AND VEGF |
| DK3659433T3 (da) * | 2018-11-30 | 2021-04-19 | Phytobiotics Futterzusatzstoffe Gmbh | System til analyse af billeder af dyrs afføring |
| CN111377832A (zh) * | 2018-12-27 | 2020-07-07 | 江苏联昇化学有限公司 | 一种伊卢多啉中间体制备的新方法 |
| JP7564824B2 (ja) | 2019-04-29 | 2024-10-09 | アイポイント ファーマシューティカルズ， インコーポレイテッド | シュレム管を標的とするＴｉｅ－２活性化物質 |
| WO2021198780A1 (en) | 2020-03-30 | 2021-10-07 | Allergan Holdings Unlimited Company | Forms of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
| MX2023001274A (es) * | 2020-07-28 | 2023-04-24 | Jazz Pharmaceuticals Ireland Ltd | Sintesis quiral de inhibidores de raf biciclicos fusionados. |
| US11850319B2 (en) | 2020-09-29 | 2023-12-26 | Abl Ip Holding Llc | Techniques for directing ultraviolet energy towards a moving surface |
| US11896728B2 (en) | 2020-09-29 | 2024-02-13 | Abl Ip Holding Llc | Techniques for directing ultraviolet energy towards a moving surface |
| CN114163348A (zh) * | 2020-11-27 | 2022-03-11 | 成都泰蓉生物科技有限公司 | 一种氨酰基取代的l-苯丙氨酸的合成方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD142804A3 (de) * | 1977-11-07 | 1980-07-16 | Wagner Guenter | Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden |
| US4879398A (en) * | 1987-12-31 | 1989-11-07 | Monsanto Company | Process for producing 2,6-disubstituted tyrosine |
| SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
| WO1996022997A1 (en) * | 1995-01-27 | 1996-08-01 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5565568A (en) | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
| JP3950170B2 (ja) | 1995-04-13 | 2007-07-25 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | タキキニン受容体アンタゴニスト活性を有する新規な置換されたピペラジン誘導体 |
| CA2203428A1 (en) | 1995-08-21 | 1997-02-27 | Philip Arthur Hipskind | 2-acylaminopropanamides as growth hormone secretagogues |
| AU7710596A (en) | 1995-11-29 | 1997-06-19 | Nihon Nohyaku Co., Ltd. | Phenylalanine derivatives, optically active substances, salts or coordination compounds thereof, and their use as fungicides |
| US5792760A (en) | 1997-04-23 | 1998-08-11 | Eli Lilly And Company | Bisindoles as tachykinin receptor antagonists |
| IT1304898B1 (it) | 1998-09-08 | 2001-04-05 | Menarini Ricerche Spa | Prodotti con caratteristiche basiche aventi attivita' antagonista sulrecettore nk-1 e loro impiego in preparazioni farmaceutiche |
| ES2206139T3 (es) * | 1999-05-28 | 2004-05-16 | Pfizer Products Inc. | Derivados de 3-(3-hidrofenil)-3-amino-propionamida. |
| FR2796643B1 (fr) | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| US20020072017A1 (en) * | 2000-10-19 | 2002-06-13 | Hudnall Phillip Montgomery | Stabilized p-phenylenediamine-type photographic color developers in free base form |
| HU230376B1 (hu) | 2000-10-30 | 2016-03-29 | Janssen Pharmaceutica N.V | Tripeptidil peptidáz inhibitorok |
| AU2002346994B2 (en) * | 2001-10-15 | 2007-09-06 | Janssen Pharmaceutica N.V. | Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| US7041681B2 (en) | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| RS54199B1 (sr) * | 2004-03-15 | 2015-12-31 | Janssen Pharmaceutica Nv | Postupak za dobijanje intermedijera jedinjenja korisnih kao modulatori opioidnih receptora |
| CN1980917B (zh) * | 2004-05-03 | 2014-02-12 | 詹森药业有限公司 | 作为选择性雄激素受体调节剂（sarms）的新的吲哚衍生物 |
| EA014366B1 (ru) * | 2005-03-14 | 2010-10-29 | Янссен Фармацевтика, Н.В. | Способ получения опиоидных модуляторов |
-
2005
- 2005-03-14 RS RS20150204A patent/RS54199B1/sr unknown
- 2005-03-14 SI SI200531934T patent/SI2573068T1/sl unknown
- 2005-03-14 RS RS20160843A patent/RS55122B1/sr unknown
- 2005-03-14 TW TW094107612A patent/TWI361069B/zh not_active IP Right Cessation
- 2005-03-14 ES ES05728171T patent/ES2367576T3/es not_active Expired - Lifetime
- 2005-03-14 CA CA2560047A patent/CA2560047C/en not_active Expired - Lifetime
- 2005-03-14 PT PT131734543T patent/PT2653465T/pt unknown
- 2005-03-14 EP EP10182349.0A patent/EP2298744B1/en not_active Expired - Lifetime
- 2005-03-14 ES ES10182349T patent/ES2428008T3/es not_active Expired - Lifetime
- 2005-03-14 ES ES16178050T patent/ES2705077T3/es not_active Expired - Lifetime
- 2005-03-14 PL PL12194058T patent/PL2573068T3/pl unknown
- 2005-03-14 MX MXPA06010642A patent/MXPA06010642A/es active IP Right Grant
- 2005-03-14 EP EP16178050.7A patent/EP3112352B1/en not_active Expired - Lifetime
- 2005-03-14 LT LTEP13173454.3T patent/LT2653465T/lt unknown
- 2005-03-14 ME MEP-2015-36A patent/ME02221B/me unknown
- 2005-03-14 WO PCT/US2005/008339 patent/WO2005090315A1/en not_active Ceased
- 2005-03-14 ES ES13173454.3T patent/ES2596434T3/es not_active Expired - Lifetime
- 2005-03-14 ME MEP-2013-97A patent/ME01601B/me unknown
- 2005-03-14 CN CN201210277845.6A patent/CN102786476B/zh not_active Expired - Fee Related
- 2005-03-14 HR HR20110694T patent/HRP20110694T1/hr unknown
- 2005-03-14 DK DK16178050.7T patent/DK3112352T3/en active
- 2005-03-14 RS RS20110446A patent/RS51995B/sr unknown
- 2005-03-14 KR KR1020067021231A patent/KR101166342B1/ko not_active Expired - Fee Related
- 2005-03-14 MY MYPI20051060A patent/MY146972A/en unknown
- 2005-03-14 PT PT101823490T patent/PT2298744E/pt unknown
- 2005-03-14 PL PL13173454T patent/PL2653465T3/pl unknown
- 2005-03-14 PL PL05728171T patent/PL1725537T3/pl unknown
- 2005-03-14 UA UAA200609824A patent/UA86053C2/ru unknown
- 2005-03-14 RS RS20130371A patent/RS52933B/sr unknown
- 2005-03-14 SI SI200532091A patent/SI2653465T1/sl unknown
- 2005-03-14 EP EP13173454.3A patent/EP2653465B1/en not_active Expired - Lifetime
- 2005-03-14 SI SI200531771T patent/SI2298744T1/sl unknown
- 2005-03-14 PT PT121940589T patent/PT2573068E/pt unknown
- 2005-03-14 EP EP05728171A patent/EP1725537B1/en not_active Expired - Lifetime
- 2005-03-14 US US11/079,647 patent/US7741356B2/en active Active
- 2005-03-14 PT PT05728171T patent/PT1725537E/pt unknown
- 2005-03-14 PL PL10182349T patent/PL2298744T3/pl unknown
- 2005-03-14 ES ES12194058.9T patent/ES2533176T3/es not_active Expired - Lifetime
- 2005-03-14 ME MEP-2016-232A patent/ME02540B/me unknown
- 2005-03-14 DK DK10182349.0T patent/DK2298744T3/da active
- 2005-03-14 DK DK13173454.3T patent/DK2653465T3/da active
- 2005-03-14 DK DK12194058.9T patent/DK2573068T3/en active
- 2005-03-14 NZ NZ549842A patent/NZ549842A/en not_active IP Right Cessation
- 2005-03-14 HU HUE13173454A patent/HUE029852T2/en unknown
- 2005-03-14 EP EP12194058.9A patent/EP2573068B9/en not_active Expired - Lifetime
- 2005-03-14 AT AT05728171T patent/ATE516274T1/de active
- 2005-03-14 SI SI200531383T patent/SI1725537T1/sl unknown
- 2005-03-14 DK DK05728171.9T patent/DK1725537T3/da active
- 2005-03-14 BR BRPI0508820A patent/BRPI0508820B8/pt not_active IP Right Cessation
- 2005-03-14 CN CN200580014571XA patent/CN1950342B/zh not_active Expired - Fee Related
- 2005-03-14 AU AU2005224091A patent/AU2005224091B2/en not_active Ceased
- 2005-03-14 JP JP2007503986A patent/JP4778954B2/ja not_active Expired - Fee Related
- 2005-03-15 AR ARP050101007A patent/AR048269A1/es active IP Right Grant
-
2006
- 2006-09-12 IL IL178040A patent/IL178040A/en active IP Right Grant
- 2006-09-15 EC EC2006006856A patent/ECSP066856A/es unknown
- 2006-09-25 CR CR8655A patent/CR8655A/es unknown
- 2006-10-13 ZA ZA2006/08587A patent/ZA200608587B/en unknown
- 2006-10-13 NO NO20064660A patent/NO338203B1/no not_active IP Right Cessation
-
2007
- 2007-10-24 US US11/877,747 patent/US7786158B2/en active Active
-
2010
- 2010-07-19 US US12/838,825 patent/US8344011B2/en not_active Expired - Lifetime
-
2011
- 2011-10-10 CY CY20111100967T patent/CY1111927T1/el unknown
-
2012
- 2012-08-14 PH PH12012501640A patent/PH12012501640B1/en unknown
- 2012-11-30 US US13/690,041 patent/US8609709B2/en not_active Expired - Lifetime
-
2013
- 2013-02-26 IL IL224908A patent/IL224908A/en active IP Right Grant
- 2013-08-22 HR HRP20130800TT patent/HRP20130800T1/hr unknown
- 2013-10-03 US US14/045,008 patent/US8772325B2/en not_active Expired - Lifetime
- 2013-11-14 IL IL229444A patent/IL229444A/en active IP Right Grant
-
2014
- 2014-04-11 AR ARP140101566A patent/AR095848A2/es unknown
- 2014-05-20 US US14/282,828 patent/US9205076B2/en not_active Expired - Lifetime
-
2015
- 2015-03-18 HR HRP20150305TT patent/HRP20150305T1/hr unknown
- 2015-10-12 US US14/880,597 patent/US9700542B2/en not_active Expired - Lifetime
-
2016
- 2016-05-30 NO NO20160916A patent/NO20160916A1/no not_active Application Discontinuation
- 2016-10-12 HR HRP20161331TT patent/HRP20161331T1/hr unknown
- 2016-10-12 CY CY20161101019T patent/CY1118096T1/el unknown
-
2017
- 2017-02-23 NO NO2017007C patent/NO2017007I1/no unknown
- 2017-03-01 LT LTPA2017005C patent/LTC1725537I2/lt unknown
- 2017-03-01 LU LU00007C patent/LUC00007I2/fr unknown
- 2017-03-02 HU HUS1700010C patent/HUS1700010I1/hu unknown
- 2017-03-08 CY CY2017008C patent/CY2017008I1/el unknown
- 2017-03-10 NL NL300865C patent/NL300865I2/nl unknown
- 2017-06-07 US US15/616,358 patent/US10213415B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2573068T1 (sl) | Postopek za pripravo intermediatov spojin, ki so uporabne kot modulatorji opioidnega receptorja | |
| GB0615619D0 (en) | Chemical process for preparation of intermediates | |
| IL209402A0 (en) | Process for the preparation of opioid modulators | |
| ZA200903889B (en) | Process for the synthesis of moxifloxacin hydrochloride | |
| IL193822A (en) | Forms of crystals and processes for the preparation of phenyl-pyrazole are effective as 5-a2ht serotonin receptor modulators | |
| IL184715A0 (en) | Process for the preparation of intermediates | |
| HUP0500537A3 (en) | Process for the preparation of rosuvastatin via new intermediates | |
| GB0516603D0 (en) | Processes for the preparation of organic compounds useful as serotonin receptor antagonists | |
| PT1829872E (pt) | Processo para produzir um composto indole | |
| EP2081940A4 (en) | PROCESS FOR THE PREPARATION OF PRULIFLOXACIN USING NEW INTERMEDIATE PRODUCTS | |
| IL181721A0 (en) | Process for preparing bicyclic pyrazolyl compounds | |
| IL162071A (en) | Process for synthesis of dinitrotetraoxadiazaisowurtzitane (dtiw) | |
| GB0525710D0 (en) | An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds | |
| PL2170880T3 (pl) | Sposób wytwarzania związków pośrednich dla związków tetracyklicznych | |
| ZA200808813B (en) | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor | |
| IL178960A0 (en) | Process for the preparation of pyridin-2-ylmethylsulphinyl-1h-benzimidazol compounds | |
| GB0507198D0 (en) | Process for preparing bicyclic compounds | |
| EP2027105A4 (en) | NEW PROCESS FOR PRODUCING INTERMEDIATE PRODUCTS FROM CCR ANTAGONISTS | |
| HK1127774A (en) | Novel process for preparing intermediates of ccr antagonists | |
| GB0507195D0 (en) | Process for preparing bicyclic compounds | |
| GB0407724D0 (en) | Process for preparing bicyclic compounds | |
| HU2947U (en) | Apparatus for producing of biogas | |
| IL193470A0 (en) | Process for preparing of 2-alkyl-3-aryl-prop-2- ene-1-ols | |
| GB0507202D0 (en) | Process for preparing bicyclic compounds | |
| GB0507207D0 (en) | Process for preparing bicyclic compounds |