PL2061816T3 - Pochodne kwasu hialuronowego otrzymywane w wyniku sieciowania za pomocą "chemii click" - Google Patents

Pochodne kwasu hialuronowego otrzymywane w wyniku sieciowania za pomocą "chemii click"

Info

Publication number
PL2061816T3
PL2061816T3 PL07802163T PL07802163T PL2061816T3 PL 2061816 T3 PL2061816 T3 PL 2061816T3 PL 07802163 T PL07802163 T PL 07802163T PL 07802163 T PL07802163 T PL 07802163T PL 2061816 T3 PL2061816 T3 PL 2061816T3
Authority
PL
Poland
Prior art keywords
crosslinking
hyaluronic acid
acid derivatives
obtained via
click chemistry
Prior art date
Application number
PL07802163T
Other languages
English (en)
Inventor
Vittorio Crescenzi
Meo Chiara Di
Devis Galesso
Original Assignee
Fidia Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici S.P.A. filed Critical Fidia Farmaceutici S.P.A.
Publication of PL2061816T3 publication Critical patent/PL2061816T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL07802163T 2006-09-11 2007-09-05 Pochodne kwasu hialuronowego otrzymywane w wyniku sieciowania za pomocą "chemii click" PL2061816T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001726A ITMI20061726A1 (it) 2006-09-11 2006-09-11 Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
EP07802163.1A EP2061816B1 (en) 2006-09-11 2007-09-05 Hyaluronic acid derivatives obtained via "click chemistry" crosslinking

Publications (1)

Publication Number Publication Date
PL2061816T3 true PL2061816T3 (pl) 2017-08-31

Family

ID=38728969

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07802163T PL2061816T3 (pl) 2006-09-11 2007-09-05 Pochodne kwasu hialuronowego otrzymywane w wyniku sieciowania za pomocą "chemii click"

Country Status (13)

Country Link
US (1) US8512752B2 (pl)
EP (1) EP2061816B1 (pl)
JP (1) JP5397770B2 (pl)
KR (1) KR20090063235A (pl)
CN (1) CN101528780B (pl)
AU (1) AU2007296939B9 (pl)
CA (1) CA2662924C (pl)
ES (1) ES2620400T3 (pl)
IL (1) IL197498A (pl)
IT (1) ITMI20061726A1 (pl)
MX (1) MX2009002653A (pl)
PL (1) PL2061816T3 (pl)
WO (1) WO2008031525A1 (pl)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2347775T3 (pl) 2005-12-13 2020-11-16 President And Fellows Of Harvard College Rusztowania do przeszczepiania komórek
WO2009018546A1 (en) 2007-08-02 2009-02-05 Medicis Pharmaceutical Corporation Method of applying an injectable filler
AU2013203710B2 (en) * 2007-11-30 2016-09-29 Allergan Industrie, Sas Polysaccharide gel formulation
WO2009102465A2 (en) 2008-02-13 2009-08-20 President And Fellows Of Harvard College Continuous cell programming devices
EP3456749B1 (en) * 2008-02-29 2021-07-14 PVAC Medical Technologies Ltd. A substituted polyvinyl alcohol reagent
US8034396B2 (en) * 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエAllergan Holdings France S.A.S. ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用
GB0816783D0 (en) 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
US9039979B2 (en) 2009-02-21 2015-05-26 Sofradim Production Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
US20120021217A1 (en) * 2009-02-21 2012-01-26 Ahmed Robert Hadba Fibers with an activated surface and method of making same by extrusion
US9375699B2 (en) 2009-02-21 2016-06-28 Sofradim Production Apparatus and method of reacting polymers by exposure to UV radiation to produce injectable medical devices
US9273191B2 (en) 2009-02-21 2016-03-01 Sofradim Production Medical devices with an activated coating
WO2010095045A1 (en) 2009-02-21 2010-08-26 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
AU2010215202A1 (en) 2009-02-21 2011-10-13 Covidien Lp Crosslinked fibers and method of making same using UV radiation
US9555154B2 (en) 2009-02-21 2017-01-31 Covidien Lp Medical devices having activated surfaces
EP2398941B1 (en) 2009-02-21 2016-07-13 Sofradim Production Crosslinked fibers and method of making same by extrusion
US8968733B2 (en) 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
US8877170B2 (en) 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
EP2398519A2 (en) 2009-02-21 2011-12-28 Sofradim Production Compounds and medical devices activated with solvophobic linkers
CA2753189A1 (en) 2009-02-21 2010-08-26 Nadya Belcheva Medical devices having activated surfaces
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
US8663689B2 (en) 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
FR2951449B1 (fr) * 2009-10-15 2011-11-25 Commissariat Energie Atomique Procede de fonctionnalisation de molecules biologiques
CZ2009836A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
EP2361640A1 (en) * 2010-02-25 2011-08-31 Université de Liège Cell cultivation in chitosan alginate hydrogel beads
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
HUE043344T2 (hu) 2010-03-22 2019-08-28 Allergan Inc Térhálósított hidrogélek lágy szövet növelésére
CA2794335A1 (en) 2010-03-25 2011-09-29 Sofradim Production Medical devices incorporating functional adhesives
AU2011231246B2 (en) 2010-03-25 2015-05-21 Sofradim Production Surgical fasteners and methods for sealing wounds
US9247931B2 (en) 2010-06-29 2016-02-02 Covidien Lp Microwave-powered reactor and method for in situ forming implants
WO2012001532A2 (en) 2010-07-01 2012-01-05 Sofradim Production Medical device with predefined activated cellular integration
AU2011284449B2 (en) 2010-07-27 2015-07-23 Sofradim Production Polymeric fibers having tissue reactive members
CZ305040B6 (cs) 2010-09-14 2015-04-08 Contipro Biotech S.R.O. Způsob přípravy vysoce substituovaných amidů kyseliny hyaluronové
EP2622594B1 (en) 2010-10-01 2018-08-22 Applied Medical Resources Corporation Portable laparoscopic trainer
JP6104806B2 (ja) 2010-10-06 2017-03-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 材料に基づく細胞治療のための注射可能孔形成性ハイドロゲル
KR101003687B1 (ko) * 2010-10-19 2010-12-23 (주)소우영 히알루론산계 화합물, 그 제조방법 및 용도
FR2967677B1 (fr) 2010-11-18 2014-05-16 Centre Nat Rech Scient Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic
AU2011334599B2 (en) * 2010-11-23 2016-12-01 Allergan Pharmaceuticals International Limited Preparation and/or formulation of proteins cross-linked with polysaccharides
FI125829B (fi) 2011-03-07 2016-02-29 Aalto Korkeakoulusã Ã Tiã Double click-teknologia
CZ304072B6 (cs) * 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
WO2012149358A1 (en) 2011-04-28 2012-11-01 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
JPWO2012165462A1 (ja) * 2011-05-31 2015-02-23 国立大学法人 東京大学 ハイドロゲル及びその製造方法
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
KR102015676B1 (ko) 2011-06-03 2019-10-21 알러간, 인코포레이티드 항산화제를 포함하는 피부 충전제 조성물
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
JP6062426B2 (ja) 2011-06-03 2017-01-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー抗原生成癌ワクチン
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
KR101963610B1 (ko) 2011-10-21 2019-03-29 어플라이드 메디컬 리소시스 코포레이션 수술 트레이닝용 모의 조직 구조
CN102532502B (zh) * 2011-12-13 2013-09-04 暨南大学 生物功能化可降解聚酯及其制备方法
CA2859967A1 (en) 2011-12-20 2013-06-27 Applied Medical Resources Corporation Advanced surgical simulation
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
LT2838515T (lt) 2012-04-16 2020-03-10 President And Fellows Of Harvard College Mezoporinės silico dioksido kompozicijos, skirtos imuninio atsako moduliavimui
CN102772823A (zh) * 2012-07-25 2012-11-14 华南理工大学 透明质酸/明胶/硫酸软骨素骨修复仿生支架的制备方法
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CA2885433C (en) 2012-09-26 2023-04-04 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
US10679520B2 (en) 2012-09-27 2020-06-09 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
JP6245531B2 (ja) 2012-09-27 2017-12-13 アプライド メディカル リソーシーズ コーポレイション 腹腔鏡下手技用の外科用訓練モデル
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CN105008402B (zh) * 2013-02-22 2018-09-18 佳能株式会社 近红外色素结合的透明质酸衍生物和包括其的光学成像用造影剂
ES2897418T3 (es) 2013-03-01 2022-03-01 Applied Med Resources Construcciones y métodos de simulación quirúrgica avanzada
CN104056298B (zh) * 2013-03-18 2017-04-26 李锋 无规共聚物的伤口应用
KR102231989B1 (ko) 2013-06-18 2021-03-25 어플라이드 메디컬 리소시스 코포레이션 수술 절차들을 가르치고 실습하기 위한 담낭 모델
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
JP6517201B2 (ja) 2013-07-24 2019-05-22 アプライド メディカル リソーシーズ コーポレイション ファーストエントリーモデル
US10198966B2 (en) 2013-07-24 2019-02-05 Applied Medical Resources Corporation Advanced first entry model for surgical simulation
JP2016172783A (ja) * 2013-08-08 2016-09-29 生化学工業株式会社 組織膨隆材
WO2015044455A1 (en) 2013-09-30 2015-04-02 Galderma S.A. Single-step functionalization and cross-linking of hyaluronic acid
JP6383740B2 (ja) * 2014-02-06 2018-08-29 国立研究開発法人科学技術振興機構 ペプチド/β−1,3−グルカン複合体及びそれを含む医薬組成物
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
KR102438168B1 (ko) 2014-03-26 2022-08-31 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 절개가능 조직
ES2951908T3 (es) 2014-04-04 2023-10-25 Harvard College Hidrogeles reticulados por química clic y métodos de uso
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
EP3620184A1 (en) 2014-09-30 2020-03-11 Allergan Industrie, SAS Stable hydrogel compositions including additives
KR102615540B1 (ko) 2014-11-13 2023-12-19 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 조직 모델들 및 방법들
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
JP6806684B2 (ja) 2015-02-19 2021-01-06 アプライド メディカル リソーシーズ コーポレイション 模擬組織構造体および方法
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
EP3280464A4 (en) 2015-04-10 2018-09-26 President and Fellows of Harvard College Immune cell trapping devices and methods for making and using the same
US20160311973A1 (en) 2015-04-24 2016-10-27 The Penn State Research Foundation Clickable waterborne polymers and click-crosslinked waterborne polymers, clickable functional compounds, click functionalized waterborne polymers, and uses thereof
WO2016183412A1 (en) 2015-05-14 2016-11-17 Applied Medical Resources Corporation Synthetic tissue structures for electrosurgical training and simulation
JP6820281B2 (ja) 2015-06-09 2021-01-27 アプライド メディカル リソーシーズ コーポレイション 子宮摘出術モデル
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CA2992552A1 (en) 2015-07-16 2017-01-19 Applied Medical Resources Corporation Simulated dissectable tissue
ES2883261T3 (es) 2015-07-22 2021-12-07 Applied Med Resources Modelo de apendicectomía
KR20240037386A (ko) 2015-10-02 2024-03-21 어플라이드 메디컬 리소시스 코포레이션 자궁 절제술 모델
US10706743B2 (en) 2015-11-20 2020-07-07 Applied Medical Resources Corporation Simulated dissectible tissue
CN105504316B (zh) * 2016-01-29 2017-12-29 清华大学 一种透明质酸‑甲基纤维素复合凝胶的活性酯交联方法
CN109072197A (zh) 2016-02-06 2018-12-21 哈佛学院校长同事会 重塑造血巢以重建免疫
CN107400247B (zh) * 2016-05-19 2020-04-28 北京化工大学 一种原位交联水凝胶
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
KR102405187B1 (ko) 2016-06-27 2022-06-07 어플라이드 메디컬 리소시스 코포레이션 시뮬레이션된 복벽
WO2018013797A1 (en) 2016-07-13 2018-01-18 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
EP3583589A1 (en) 2017-02-14 2019-12-25 Applied Medical Resources Corporation Laparoscopic training system
US10847057B2 (en) 2017-02-23 2020-11-24 Applied Medical Resources Corporation Synthetic tissue structures for electrosurgical training and simulation
AU2018240375C1 (en) 2017-03-22 2024-02-01 Ascendis Pharma A/S Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
KR20190134660A (ko) * 2017-03-29 2019-12-04 히타치가세이가부시끼가이샤 전하 수송성 재료 및 그 이용
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
AU2018269057A1 (en) * 2017-05-18 2019-11-07 The Board Of Trustees Of The Leland Stanford Junior University Targeted in situ therapeutic delivery of secreted factors from stem cells for treatment of damaged tissue
KR102071111B1 (ko) * 2017-10-11 2020-01-29 아주대학교산학협력단 성장인자 모사 펩타이드가 도입된 생체물질, 이의 제조방법 및 이의 응용
KR102103180B1 (ko) * 2017-12-22 2020-04-22 케이비바이오메드 주식회사 히알루론산유도체, 플루란 및 카르복시메틸 셀룰로오스를 포함하는 유착방지용 조성물 및 이의 제조방법
FI129257B (en) * 2017-12-29 2021-10-15 Fortum Oyj Method for derivatizing cellulose
KR102213196B1 (ko) * 2018-05-08 2021-02-05 주식회사 메디폴리머 클릭화학 반응을 통해 필러 또는 약물전달체로 사용하기 위한 주사제형 조성물
CN108721695A (zh) * 2018-05-29 2018-11-02 金陵科技学院 一种可注射性复合水凝胶细胞载体支架的制备方法
CN112543791B (zh) * 2018-05-31 2023-06-30 根特大学 基于双官能改性的生物聚合物的聚合物和能够由这种基于双官能改性的生物聚合物的聚合物获得的水凝胶
EP3808783A4 (en) 2018-06-14 2022-03-16 Mochida Pharmaceutical Co., Ltd. NOVEL LINKED ALGIC ACID
JP2021529863A (ja) * 2018-06-28 2021-11-04 ハルーラ リミテッド 架橋ポリカルボキシル化多糖およびその使用方法
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
CN109735819B (zh) * 2019-03-14 2020-01-31 西南交通大学 具有NO催化释放与EPCs捕获功能的生物材料及其制备方法
KR20220005465A (ko) * 2019-04-19 2022-01-13 조인테라퓨틱스 에스알엘 작용화된 히알루론산의 가교결합 중합체 및 염증 상태의 치료에서의 이의 용도
KR102152939B1 (ko) * 2019-04-30 2020-09-07 한국화학연구원 공유결합성 트리아졸로 연결된 가시광선 흡수 광촉매, 이의 제조방법 및 이를 이용한 아자이드-알카인 고리화 첨가반응으로 트리아졸 유도체를 제조하는 방법
EP4035735A4 (en) * 2019-09-25 2023-10-18 Mochida Pharmaceutical Co., Ltd. NOVEL STRUCTURE OF CROSS-LINKED ALGINIC ACID
KR102365327B1 (ko) * 2019-10-04 2022-02-18 부경대학교 산학협력단 근적외선을 이용한 외부자극 감응형 하이드로겔 담체, 이의 제조방법 및 이를 이용한 약물 전달 시스템
WO2021125255A1 (ja) 2019-12-18 2021-06-24 持田製薬株式会社 新規な架橋アルギン酸
JPWO2022034889A1 (pl) * 2020-08-14 2022-02-17
CN113214504A (zh) * 2021-04-20 2021-08-06 河南工业大学 一种基于天然高分子的半互穿网络抑菌凝胶的制备方法
CN113667141B (zh) * 2021-07-09 2023-10-03 深圳华源再生医学有限公司 抗蛋白粘附的海藻酸盐水凝胶及其制备方法和应用
CN115068671B (zh) * 2022-06-20 2023-07-28 常州华联医疗器械集团股份有限公司 一种海藻酸钠水凝胶敷料的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US6673905B2 (en) * 2000-08-09 2004-01-06 The United States Of America As Represented By The Department Of Health And Human Services Conjugation of biomolecules using Diels-Alder cycloaddition
IT1317358B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
JP4172176B2 (ja) * 2000-12-19 2008-10-29 生化学工業株式会社 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料
KR101048279B1 (ko) * 2002-05-30 2011-07-13 더 스크립스 리서치 인스티튜트 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션
US20050032081A1 (en) * 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US9290617B2 (en) 2005-07-06 2016-03-22 Molly S. Shoichet Method of biomolecule immobilization on polymers using click-type chemistry
US20090220607A1 (en) * 2005-09-15 2009-09-03 Kiser Patrick F Polymeric compositions and methods of making and using thereof
BRPI0711835A2 (pt) * 2006-05-15 2011-12-13 Rhodia Operations compostos hìbridos à base de poliol(is) e à base de pelo menos uma outra entidade molecular, poliméricos ou não, notadamente do tipo poliorganosiloxana, processo de preparação dos mesmos e suas aplicações

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