PH25932A - Adenosine derivatives and pharmaceutical compositions containing the same - Google Patents

Adenosine derivatives and pharmaceutical compositions containing the same

Info

Publication number
PH25932A
PH25932A PH37978A PH37978A PH25932A PH 25932 A PH25932 A PH 25932A PH 37978 A PH37978 A PH 37978A PH 37978 A PH37978 A PH 37978A PH 25932 A PH25932 A PH 25932A
Authority
PH
Philippines
Prior art keywords
same
pharmaceutical compositions
compositions containing
adenosine derivatives
adenosine
Prior art date
Application number
PH37978A
Other languages
English (en)
Inventor
Brian Evans
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PH25932A publication Critical patent/PH25932A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH37978A 1987-12-23 1988-12-23 Adenosine derivatives and pharmaceutical compositions containing the same PH25932A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878729994A GB8729994D0 (en) 1987-12-23 1987-12-23 Chemical compounds

Publications (1)

Publication Number Publication Date
PH25932A true PH25932A (en) 1991-12-19

Family

ID=10628947

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37978A PH25932A (en) 1987-12-23 1988-12-23 Adenosine derivatives and pharmaceutical compositions containing the same

Country Status (36)

Country Link
US (1) US5032583A (it)
EP (1) EP0322242B1 (it)
JP (1) JP2736088B2 (it)
KR (1) KR890009967A (it)
CN (1) CN1024198C (it)
AT (1) ATA315488A (it)
AU (2) AU612747B2 (it)
BE (1) BE1002167A5 (it)
CA (1) CA1320195C (it)
CH (1) CH677495A5 (it)
CZ (1) CZ403991A3 (it)
DE (2) DE3856154T2 (it)
DK (1) DK170894B1 (it)
ES (1) ES2012927A6 (it)
FI (1) FI90429C (it)
FR (1) FR2629715B1 (it)
GB (2) GB8729994D0 (it)
GR (1) GR1000307B (it)
HK (1) HK1009650A1 (it)
HU (1) HU203364B (it)
IE (1) IE61302B1 (it)
IL (1) IL88765A (it)
IT (1) IT1224840B (it)
LU (1) LU87414A1 (it)
MX (1) MX14331A (it)
NL (1) NL8803140A (it)
NO (1) NO171506C (it)
NZ (1) NZ227485A (it)
PH (1) PH25932A (it)
PL (1) PL158800B1 (it)
PT (1) PT89328B (it)
RU (2) RU1826971C (it)
SE (1) SE8804609L (it)
SG (1) SG44701A1 (it)
YU (1) YU234188A (it)
ZA (1) ZA889593B (it)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
FR2665362B1 (fr) * 1990-08-03 1994-12-09 Cepbepe Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application.
ES2095960T3 (es) * 1990-09-25 1997-03-01 Rhone Poulenc Rorer Int Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
DK62692D0 (it) * 1992-05-14 1992-05-14 Novo Nordisk As
US5672588A (en) * 1992-05-20 1997-09-30 Novo Nordisk A/S Purine derivatives
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
BR9507683A (pt) * 1994-05-10 1997-09-23 Sandoz Ag Derivados de adenosina
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033590A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
BR9911612A (pt) 1998-06-02 2001-02-06 Osi Pharm Inc Composições de pirrolo[2,3d]pirimidina e seus usos
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6784165B1 (en) 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
GB9930077D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
JP2005529062A (ja) 2001-11-30 2005-09-29 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アデノシンa1及びa3受容体に特異的な化合物とその使用
EP1465631B1 (en) 2001-12-20 2010-02-24 OSI Pharmaceuticals, Inc. Pyrimidine a2b selective antagonist compounds, their synthesis and use
CN101973998A (zh) 2001-12-20 2011-02-16 Osi药物公司 吡咯并嘧啶A2b选择性拮抗剂化合物
MXPA05011428A (es) * 2003-04-24 2006-05-31 Aderis Pharmaceuticals Inc Metodo de tratamiento de fibrilacion atrial o trepidacion auricular.
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
BR112012004523A2 (pt) 2009-08-31 2015-09-08 Lonza Ag processo para a preparação de (1s,4r)-2-oxa-3-azabiciclo[2.2.1]hept-5-enos
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130136C (it) * 1966-10-20
NL6717061A (it) * 1966-12-21 1968-06-24
DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
NL7203984A (it) * 1971-04-10 1972-10-12
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
DE2148838A1 (de) * 1971-09-30 1973-04-05 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2157036A1 (de) * 1971-11-17 1973-05-24 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung
DE2244328A1 (de) * 1972-09-09 1974-03-21 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338705A1 (de) * 1973-07-31 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338963A1 (de) * 1973-08-01 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2426682A1 (de) * 1974-06-01 1975-12-11 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
ZA857998B (en) * 1984-10-26 1986-05-28 Warner Lambert Co N6-substituted adenosines
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines

Also Published As

Publication number Publication date
HU203364B (en) 1991-07-29
AU2740188A (en) 1989-06-29
HUT48903A (en) 1989-07-28
IL88765A (en) 1993-04-04
CN1035295A (zh) 1989-09-06
GR1000307B (el) 1992-05-12
KR890009967A (ko) 1989-08-05
IE883845L (en) 1989-06-23
HK1009650A1 (en) 1999-06-04
EP0322242A3 (en) 1990-04-18
CZ403991A3 (en) 1993-04-14
EP0322242B1 (en) 1998-04-01
DE3856154D1 (de) 1998-05-07
IT1224840B (it) 1990-10-24
RU2060996C1 (ru) 1996-05-27
GB8829983D0 (en) 1989-02-15
GB8729994D0 (en) 1988-02-03
DK170894B1 (da) 1996-03-04
AU612747B2 (en) 1991-07-18
ATA315488A (de) 1994-02-15
MX14331A (es) 1993-12-01
NO171506C (no) 1993-03-24
AU8589491A (en) 1991-12-12
CA1320195C (en) 1993-07-13
FI885943A (fi) 1989-06-24
CN1024198C (zh) 1994-04-13
NO885719D0 (no) 1988-12-22
US5032583A (en) 1991-07-16
DE3843609A1 (de) 1989-07-06
NO885719L (no) 1989-06-26
PT89328A (pt) 1989-12-29
DE3856154T2 (de) 1998-08-27
SE8804609D0 (sv) 1988-12-21
FI90429B (fi) 1993-10-29
IE61302B1 (en) 1994-10-19
JPH01203400A (ja) 1989-08-16
RU1826971C (ru) 1993-07-07
IL88765A0 (en) 1989-07-31
SG44701A1 (en) 1997-12-19
FR2629715A1 (fr) 1989-10-13
FI90429C (fi) 1994-02-10
GB2212498B (en) 1991-07-24
NO171506B (no) 1992-12-14
CH677495A5 (it) 1991-05-31
DK713488D0 (da) 1988-12-21
IT8848714A0 (it) 1988-12-23
DK713488A (da) 1989-06-24
NZ227485A (en) 1991-06-25
JP2736088B2 (ja) 1998-04-02
BE1002167A5 (fr) 1990-08-28
NL8803140A (nl) 1989-07-17
ES2012927A6 (es) 1990-04-16
SE8804609L (sv) 1989-06-24
PL158800B1 (en) 1992-10-30
PT89328B (pt) 1993-08-31
ZA889593B (en) 1989-09-27
FR2629715B1 (fr) 1993-09-03
GB2212498A (en) 1989-07-26
YU234188A (en) 1990-12-31
EP0322242A2 (en) 1989-06-28
LU87414A1 (fr) 1989-07-07
PL276697A1 (en) 1990-02-19

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