PH22082A - Anti-inflammatory products derived from methylene-diphosphonic acid - Google Patents

Anti-inflammatory products derived from methylene-diphosphonic acid

Info

Publication number
PH22082A
PH22082A PH29310A PH29310A PH22082A PH 22082 A PH22082 A PH 22082A PH 29310 A PH29310 A PH 29310A PH 29310 A PH29310 A PH 29310A PH 22082 A PH22082 A PH 22082A
Authority
PH
Philippines
Prior art keywords
methylene
diphosphonic acid
products derived
inflammatory products
inflammatory
Prior art date
Application number
PH29310A
Other languages
English (en)
Inventor
Breliere Jean Claude
Edmonds-Alt Xavier
Garcia Georges
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PH22082A publication Critical patent/PH22082A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH29310A 1982-07-29 1983-07-27 Anti-inflammatory products derived from methylene-diphosphonic acid PH22082A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (1)

Publication Number Publication Date
PH22082A true PH22082A (en) 1988-05-20

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
PH29310A PH22082A (en) 1982-07-29 1983-07-27 Anti-inflammatory products derived from methylene-diphosphonic acid

Country Status (35)

Country Link
US (2) US4746654A (cs)
EP (1) EP0100718B1 (cs)
JP (1) JPS5942395A (cs)
KR (1) KR910000726B1 (cs)
AR (2) AR242393A1 (cs)
AT (1) ATE30235T1 (cs)
AU (1) AU566880B2 (cs)
CA (1) CA1267650A (cs)
CS (1) CS252463B2 (cs)
CZ (1) CZ419191A3 (cs)
DD (1) DD213670A5 (cs)
DE (1) DE3374062D1 (cs)
DK (1) DK170342B1 (cs)
DZ (1) DZ562A1 (cs)
EG (1) EG15968A (cs)
ES (1) ES524495A0 (cs)
FI (1) FI75830C (cs)
FR (1) FR2531088B1 (cs)
GR (1) GR79597B (cs)
HU (1) HU190454B (cs)
IE (1) IE56343B1 (cs)
IL (1) IL69347A (cs)
LU (1) LU88723I2 (cs)
MA (1) MA19858A1 (cs)
NL (1) NL960007I2 (cs)
NO (2) NO164712C (cs)
NZ (1) NZ205061A (cs)
OA (1) OA07507A (cs)
PH (1) PH22082A (cs)
PL (2) PL142022B1 (cs)
PT (1) PT77122B (cs)
SG (1) SG18588G (cs)
SU (2) SU1333240A3 (cs)
YU (1) YU45143B (cs)
ZA (1) ZA835578B (cs)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
US5641762A (en) * 1985-05-02 1997-06-24 Research Corporation Technologies, Inc. Bone targeted inhibitors of carbonic anhydrase
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
EP0282309A3 (en) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (cs) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP3021035B2 (ja) * 1988-11-01 2000-03-15 アーク・デベロップメント・コーポレーション ホスホン酸及び分離におけるその使用
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
EP0438375B1 (de) * 1990-01-18 1995-12-27 Ciba-Geigy Ag Phoshponsäure- und Thionophosphonsäure-Derivate
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
DE69108733T2 (de) * 1990-08-21 1995-09-14 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
CA2094123A1 (en) * 1990-12-07 1992-06-08 Pharmacia & Upjohn Company Llc Phosphonic acid derivatives useful as antiinflammatory agents
DE69116838T2 (de) * 1990-12-19 1996-06-13 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre Produktion und ihre Verwendung
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
EP0590009B1 (en) * 1991-06-19 1998-03-18 PHARMACIA & UPJOHN COMPANY Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
ES2114946T3 (es) * 1991-09-05 1998-06-16 Toray Industries Derivado de acido metanodifosfonico, su produccion y uso medicinal.
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
KR100266484B1 (ko) * 1992-05-29 2000-09-15 제이코버스 코넬리스 레이서 칼슘및인산염의이상대사를치료하기위한티오-치환된질소-함유헤테로사이클릭포스포네이트화합물
CZ296794A3 (en) * 1992-05-29 1995-04-12 Procter & Gamble Pharma Phosphonate sulfur-containing compounds and their use in the preparation of a pharmaceutical for treating abnormal metabolism of calcium and phosphate
ATE168379T1 (de) * 1992-05-29 1998-08-15 Procter & Gamble Pharma Quaternare stickstoff-enthaltende phosphonat- verbindungen zur behandlung abnormalen calzium und phosphat-metabolismus sowie zahnsteinbildung
SK160994A3 (en) * 1992-06-30 1996-01-10 Procter & Gamble Pharma Compositions for the treatment of arthritis containing phosphonates and nsaid
ES2155446T3 (es) * 1992-07-10 2001-05-16 Toray Industries Derivado de metanodifosfonato, su produccion y su uso farmaceutico.
GB9215433D0 (en) * 1992-07-21 1992-09-02 Cmb Foodcan Plc Apparatus for stripping a drawn article from a punch
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
WO1994003463A1 (en) * 1992-08-07 1994-02-17 The Upjohn Company Phosphonoacetic esters and acids as anti-inflammatories
WO1994009017A1 (en) * 1992-10-09 1994-04-28 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
AU670337B2 (en) 1992-11-30 1996-07-11 Novartis Ag Use of certain methanebisphosphonic acid derivatives in fracture healing
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
FI944998A7 (fi) * 1993-02-25 1994-10-24 Toray Industries Menetelmä metaanidifosfonihappoyhdisteen valmistamiseksi
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
KR100369929B1 (ko) * 1994-08-24 2003-04-08 도레이 가부시끼가이샤 메탄디포스폰산 화합물의 제조법
EP0831756A1 (en) 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
EP0854724B1 (en) * 1995-09-29 2005-03-16 Novartis AG Method of treating the navicular disease in horses
EP0944635A4 (en) * 1996-10-09 2000-07-05 Elizanor Biopharmaceuticals In THERAPEUTIC DIPHOSPHONATE COMPOUNDS
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
DE69910045T2 (de) 1998-09-09 2004-04-22 Metabasis Therapeutics Inc., San Diego Neue heteroaromatische fructose 1,6-bisphosphatase inhibitoren
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
US6579860B1 (en) * 1998-12-25 2003-06-17 Toray Industries, Inc. Interleukin-6 production inhibitors
WO2001008123A1 (en) * 1999-07-23 2001-02-01 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions and methods of making
US6900282B2 (en) * 1999-07-23 2005-05-31 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
EP1248790A1 (en) * 1999-12-17 2002-10-16 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
CN100595204C (zh) * 1999-12-22 2010-03-24 症变治疗公司 双氨基化膦酸酯前药
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
EP2260852A3 (en) * 2001-04-10 2011-01-12 MBC Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TWI315982B (en) 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
NZ532994A (en) * 2001-12-21 2008-05-30 Procter & Gamble Method for the treatment of bone disorders using a bisphosphonate regimen, risedronate in particular
WO2003061566A2 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
WO2003086415A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
BR0308901A (pt) * 2002-05-10 2005-01-04 Hoffmann La Roche ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
AU2003250218B2 (en) * 2002-12-20 2006-10-26 F. Hoffmann-La Roche Ag High dose Ibandronate formulation
WO2005007034A1 (en) 2003-07-08 2005-01-27 The Children's Hospital Of Philadelphia Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
AU2004266740B2 (en) 2003-08-21 2010-08-26 Merck Frosst Canada Ltd Cathepsin cysteine protease inhibitors
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
NZ551118A (en) 2004-05-24 2010-09-30 Warner Chilcott Co Llc Enteric solid oral dosage form of bisphosphonate containing a chelating agent
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP2008510018A (ja) * 2004-08-18 2008-04-03 メタバシス・セラピューティクス・インコーポレイテッド フルクトース−１，６−ビスホスファターゼの新規チアゾール阻害物質
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
PT1855674E (pt) 2005-03-02 2014-10-08 Merck Canada Inc Composição para a inibição de catepsina k
EP1865928A1 (en) * 2005-03-17 2007-12-19 Elan Pharma International Limited Nanoparticulate biphosphonate compositions
WO2006102603A2 (en) * 2005-03-24 2006-09-28 Medtronic, Inc. Modification of thermoplastic polymers
CN101945853B (zh) 2007-12-21 2014-08-20 配体药物公司 选择性雄激素受体调节剂(sarm)及其应用
WO2010019511A2 (en) 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
WO2010143193A1 (en) 2009-06-11 2010-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
US8791162B2 (en) 2011-02-14 2014-07-29 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
LT2731591T (lt) 2011-07-13 2020-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomos, kuriose kartu inkapsuliuotas bisfosfonatas ir amfipatinis agentas
RU2640582C2 (ru) 2011-08-01 2018-01-10 Мбс Фарма, Инк. Производные витамина в6 нуклеотидов, ациклических нуклеотидов и ациклических нуклеозидных фосфонатов
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
EP3055314B1 (en) 2013-10-08 2018-09-12 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
BR112016027778A2 (pt) 2014-05-30 2017-08-15 Pfizer Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
JP2022529341A (ja) 2019-04-19 2022-06-21 リガンド・ファーマシューティカルズ・インコーポレイテッド 化合物の結晶形、および化合物の結晶形を生成する方法
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302557B (cs) * 1963-04-09 1971-08-26
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3654151A (en) * 1970-04-13 1972-04-04 Monsanto Co Deflocculation of solid materials in aqueous medium
US3705191A (en) * 1970-04-13 1972-12-05 Monsanto Co Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US4171373A (en) * 1974-01-07 1979-10-16 William H. Rorer, Inc. Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation
US4071584A (en) * 1977-01-03 1978-01-31 Monsanto Company Hydroxyphenylthiophosphoranylidene organophosphorus compounds
US4264582A (en) * 1978-07-31 1981-04-28 The Procter & Gamble Company Isobutylphenylacetate anti-inflammatory composition
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4330530A (en) * 1980-12-22 1982-05-18 The Procter & Gamble Company Anti-arthritic compositions and method using gold salts and organophosphonates
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
EP0100718B1 (fr) 1987-10-14
PT77122B (fr) 1986-01-24
IE56343B1 (en) 1991-07-03
IL69347A0 (en) 1983-11-30
NZ205061A (en) 1987-08-31
DZ562A1 (fr) 2004-09-13
US4746654A (en) 1988-05-24
OA07507A (fr) 1985-03-31
CZ419191A3 (en) 1993-10-13
CS568883A2 (en) 1987-01-15
KR840005459A (ko) 1984-11-12
DK336783D0 (da) 1983-07-22
SU1333240A3 (ru) 1987-08-23
EG15968A (en) 1989-01-30
NO164712B (no) 1990-07-30
KR910000726B1 (ko) 1991-01-31
ES8403923A1 (es) 1984-04-16
SG18588G (en) 1988-09-30
FR2531088B1 (fr) 1987-08-28
JPH0429676B2 (cs) 1992-05-19
NO164712C (no) 1990-11-07
FI832758A0 (fi) 1983-07-29
AR242393A1 (es) 1993-03-31
NL960007I1 (nl) 1996-09-02
NL960007I2 (nl) 1997-03-03
MA19858A1 (fr) 1984-04-01
DK170342B1 (da) 1995-08-07
GR79597B (cs) 1984-10-31
FI75830C (fi) 1988-08-08
ATE30235T1 (de) 1987-10-15
DD213670A5 (de) 1984-09-19
PL243229A1 (en) 1984-07-16
ZA835578B (en) 1984-04-25
DE3374062D1 (en) 1987-11-19
PT77122A (fr) 1983-08-01
ES524495A0 (es) 1984-04-16
CS252463B2 (en) 1987-09-17
HU190454B (en) 1986-09-29
YU160083A (en) 1986-08-31
IE831716L (en) 1984-01-29
US4876248A (en) 1989-10-24
NO1998011I1 (no) 1998-03-06
SU1367859A3 (ru) 1988-01-15
AR242394A1 (es) 1993-03-31
CA1267650A (en) 1990-04-10
AU1732483A (en) 1984-02-02
AU566880B2 (en) 1987-11-05
FR2531088A1 (fr) 1984-02-03
FI75830B (fi) 1988-04-29
NO832701L (no) 1984-01-30
JPS5942395A (ja) 1984-03-08
DK336783A (da) 1984-01-30
LU88723I2 (fr) 1996-08-23
EP0100718A1 (fr) 1984-02-15
IL69347A (en) 1987-02-27
YU45143B (en) 1992-03-10
PL141316B1 (en) 1987-07-31
PL142022B1 (en) 1987-09-30
FI832758L (fi) 1984-01-30

Similar Documents

Publication Publication Date Title
PH22082A (en) Anti-inflammatory products derived from methylene-diphosphonic acid
JPS57176941A (en) N-substituted-amide-amino acid
GB2118184B (en) Phenoxyalkylcarboxylic acid derivatives
JPS57165355A (en) Amide-amino acid
AU558552B2 (en) Epoxy-amine-fatty acid product
ZA834307B (en) Oxazoleacetic acid derivatives
DE3267782D1 (en) 3-methylflavone-8-carboxylic acid esters
GB2102415B (en) Apovincaminic acid esters
GB2123817B (en) 4-hydroxy-3-quinoline-carboxylic acid derivatives
GB2105723B (en) New chenodeoxycholic acid 7-acylates
GB2103232B (en) Arylazo-aminonaphtholsulfonic acid
DE3371070D1 (en) 4-amino-tetrahydro-2-naphthoic acid derivatives
GB8301926D0 (en) N-methanesulfonic acid derivatives
GB8518464D0 (en) Glyoxylic acid derivative
GB8318345D0 (en) Isocarbostyryl-3-carboxylic acid derivatives
GB2124214B (en) Apovincaminic acid derivatives
GB8320494D0 (en) Aminolactonecarboxylic acid
GB2110208B (en) Vincaminic acid esters
GB2121408B (en) Tetrazolylalkanohydroxamic acid derivatives
DE3362715D1 (en) Process for the preparation of 2-hydroxy-carbazole-1-carboxylic acid
GB8311222D0 (en) 7 beta-acylamido-3-cephem-4-carboxylic acid compounds
ZA831846B (en) Phenoyxyalkylcarboxylic acid derivatives
GB2095238B (en) 7-acylamido-3-cephem-4-carboxylic acid compounds
GB8328516D0 (en) Preparing perfluoroacrylic acid ester
IE821163L (en) Indenyloxyacetic acid derivatives