PH12020550143A1 - Salts of pyrrolotriazine derivatives useful as tam inhibitors - Google Patents

Salts of pyrrolotriazine derivatives useful as tam inhibitors

Info

Publication number
PH12020550143A1
PH12020550143A1 PH12020550143A PH12020550143A PH12020550143A1 PH 12020550143 A1 PH12020550143 A1 PH 12020550143A1 PH 12020550143 A PH12020550143 A PH 12020550143A PH 12020550143 A PH12020550143 A PH 12020550143A PH 12020550143 A1 PH12020550143 A1 PH 12020550143A1
Authority
PH
Philippines
Prior art keywords
salts
derivatives useful
pyrrolotriazine derivatives
phenyl
inhibitors
Prior art date
Application number
PH12020550143A
Other languages
English (en)
Inventor
Zhongjiang Jia
Yongzhong Wu
Yongchun Pan
Jiacheng Zhou
Qun Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PH12020550143A1 publication Critical patent/PH12020550143A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH12020550143A 2017-09-27 2020-03-26 Salts of pyrrolotriazine derivatives useful as tam inhibitors PH12020550143A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

Publications (1)

Publication Number Publication Date
PH12020550143A1 true PH12020550143A1 (en) 2020-12-07

Family

ID=63794769

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12020550143A PH12020550143A1 (en) 2017-09-27 2020-03-26 Salts of pyrrolotriazine derivatives useful as tam inhibitors

Country Status (35)

Country Link
US (4) US10633387B2 (enExample)
EP (2) EP3988552A1 (enExample)
JP (3) JP7504791B2 (enExample)
KR (1) KR102739325B1 (enExample)
CN (2) CN118930549A (enExample)
AU (2) AU2018342471B2 (enExample)
BR (1) BR112020006145A2 (enExample)
CA (1) CA3077308A1 (enExample)
CL (2) CL2020000791A1 (enExample)
CO (1) CO2020005009A2 (enExample)
CR (1) CR20200179A (enExample)
CY (1) CY1124952T1 (enExample)
DK (1) DK3687996T3 (enExample)
EC (1) ECSP20021655A (enExample)
ES (1) ES2904458T3 (enExample)
GE (1) GEP20227429B (enExample)
HU (1) HUE057190T2 (enExample)
IL (1) IL273579B2 (enExample)
JO (1) JOP20200081A1 (enExample)
LT (1) LT3687996T (enExample)
MA (1) MA50655B1 (enExample)
MD (1) MD3687996T2 (enExample)
MX (1) MX2020003375A (enExample)
MY (1) MY208007A (enExample)
PE (1) PE20210002A1 (enExample)
PH (1) PH12020550143A1 (enExample)
PL (1) PL3687996T3 (enExample)
PT (1) PT3687996T (enExample)
RS (1) RS62872B1 (enExample)
SA (1) SA520411638B1 (enExample)
SG (1) SG11202002821UA (enExample)
SI (1) SI3687996T1 (enExample)
SM (1) SMT202200011T1 (enExample)
TW (1) TWI821200B (enExample)
WO (1) WO2019067594A1 (enExample)

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US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
RS60834B1 (sr) 2015-12-09 2020-10-30 Cadent Therapeutics Inc Modulatori heteroaromatskog nmda receptora i njihove upotrebe
TWI753892B (zh) 2016-03-28 2022-02-01 美商英塞特公司 作為ｔａｍ抑制劑之吡咯并三嗪化合物
EP3558318B1 (en) 2016-12-22 2023-12-20 Novartis AG Nmda receptor modulators and uses thereof
MA50655B1 (fr) 2017-09-27 2021-11-30 Incyte Corp Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam
MD3813800T2 (ro) * 2018-06-29 2025-10-31 Incyte Corp Formulări de inhibitor al AXL/MER
EP4223760B1 (en) 2018-08-03 2025-06-04 Novartis AG Heteroaromatic nmda receptor modulator and uses thereof
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
CN115697343A (zh) * 2020-03-06 2023-02-03 因赛特公司 包含axl/mer和pd-1/pd-l1抑制剂的组合疗法
US20230279024A1 (en) * 2020-07-10 2023-09-07 Beijing Findcure Biosciences, Ltd. Triazine compound and composition and use thereof
CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
WO2023286719A1 (ja) * 2021-07-13 2023-01-19 日本曹達株式会社 ウラシル化合物の製造方法

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