TWI821200B - Tam抑制劑之鹽 - Google Patents

Tam抑制劑之鹽 Download PDF

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Publication number
TWI821200B
TWI821200B TW107133765A TW107133765A TWI821200B TW I821200 B TWI821200 B TW I821200B TW 107133765 A TW107133765 A TW 107133765A TW 107133765 A TW107133765 A TW 107133765A TW I821200 B TWI821200 B TW I821200B
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Taiwan
Prior art keywords
compound
salt
phenyl
formula
cancer
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TW107133765A
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English (en)
Chinese (zh)
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TW201920186A (zh
Inventor
忠將 賈
永忠 吳
永春 潘
家謙 周
李群
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美商英塞特公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW107133765A 2017-09-27 2018-09-26 Tam抑制劑之鹽 TWI821200B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US62/564,070 2017-09-27
US201862714196P 2018-08-03 2018-08-03
US62/714,196 2018-08-03

Publications (2)

Publication Number Publication Date
TW201920186A TW201920186A (zh) 2019-06-01
TWI821200B true TWI821200B (zh) 2023-11-11

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TW107133765A TWI821200B (zh) 2017-09-27 2018-09-26 Tam抑制劑之鹽

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US (4) US10633387B2 (enExample)
EP (2) EP3687996B1 (enExample)
JP (3) JP7504791B2 (enExample)
KR (1) KR102739325B1 (enExample)
CN (2) CN111386273B (enExample)
AU (2) AU2018342471B2 (enExample)
BR (1) BR112020006145A2 (enExample)
CA (1) CA3077308A1 (enExample)
CL (2) CL2020000791A1 (enExample)
CO (1) CO2020005009A2 (enExample)
CR (1) CR20200179A (enExample)
CY (1) CY1124952T1 (enExample)
DK (1) DK3687996T3 (enExample)
EC (1) ECSP20021655A (enExample)
ES (1) ES2904458T3 (enExample)
GE (1) GEP20227429B (enExample)
HU (1) HUE057190T2 (enExample)
IL (1) IL273579B2 (enExample)
JO (1) JOP20200081A1 (enExample)
LT (1) LT3687996T (enExample)
MA (1) MA50655B1 (enExample)
MD (1) MD3687996T2 (enExample)
MX (1) MX2020003375A (enExample)
MY (1) MY208007A (enExample)
PE (1) PE20210002A1 (enExample)
PH (1) PH12020550143A1 (enExample)
PL (1) PL3687996T3 (enExample)
PT (1) PT3687996T (enExample)
RS (1) RS62872B1 (enExample)
SA (1) SA520411638B1 (enExample)
SG (1) SG11202002821UA (enExample)
SI (1) SI3687996T1 (enExample)
SM (1) SMT202200011T1 (enExample)
TW (1) TWI821200B (enExample)
WO (1) WO2019067594A1 (enExample)

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US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
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WO2017172596A1 (en) 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
ES2975336T3 (es) 2016-12-22 2024-07-04 Novartis Ag Moduladores del receptor NMDA y usos de los mismos
CA3077308A1 (en) 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
PL3813800T3 (pl) 2018-06-29 2025-08-18 Incyte Corporation Formulacje inhibitora axl/mer
ES2951872T3 (es) 2018-08-03 2023-10-25 Novartis Ag Moduladores del receptor NMDA heteroaromáticos y usos de los mismos
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
JP7556604B2 (ja) * 2020-07-10 2024-09-26 範恩柯爾生物科技（中山）有限公司 トリアジン系化合物およびその組成物と用途
CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
EP4371978A4 (en) * 2021-07-13 2025-09-10 Nippon Soda Co PROCESS FOR PRODUCING A URACIL COMPOUND

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