JP7504791B2 - Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩 - Google Patents

Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩 Download PDF

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JP7504791B2
JP7504791B2 JP2020517516A JP2020517516A JP7504791B2 JP 7504791 B2 JP7504791 B2 JP 7504791B2 JP 2020517516 A JP2020517516 A JP 2020517516A JP 2020517516 A JP2020517516 A JP 2020517516A JP 7504791 B2 JP7504791 B2 JP 7504791B2
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compound
salt
phenyl
cancer
formula
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JP2020535168A (ja
JP2020535168A5 (enExample
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ジョンジアン・ジア
ヨンジョン・ウー
ヨンチュン・パン
ジアチェン・チョウ
リー・チュン
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020517516A 2017-09-27 2018-09-26 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩 Active JP7504791B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024014546A JP7639195B2 (ja) 2017-09-27 2024-02-02 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩
JP2025025024A JP2025093936A (ja) 2017-09-27 2025-02-19 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US62/564,070 2017-09-27
US201862714196P 2018-08-03 2018-08-03
US62/714,196 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

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JP2024014546A Division JP7639195B2 (ja) 2017-09-27 2024-02-02 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩

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JP2020535168A JP2020535168A (ja) 2020-12-03
JP2020535168A5 JP2020535168A5 (enExample) 2021-10-28
JP7504791B2 true JP7504791B2 (ja) 2024-06-24

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JP2020517516A Active JP7504791B2 (ja) 2017-09-27 2018-09-26 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩
JP2024014546A Active JP7639195B2 (ja) 2017-09-27 2024-02-02 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩
JP2025025024A Pending JP2025093936A (ja) 2017-09-27 2025-02-19 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩

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JP2024014546A Active JP7639195B2 (ja) 2017-09-27 2024-02-02 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩
JP2025025024A Pending JP2025093936A (ja) 2017-09-27 2025-02-19 Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩

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CA3077308A1 (en) 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
PL3813800T3 (pl) 2018-06-29 2025-08-18 Incyte Corporation Formulacje inhibitora axl/mer
ES2951872T3 (es) 2018-08-03 2023-10-25 Novartis Ag Moduladores del receptor NMDA heteroaromáticos y usos de los mismos
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
JP7556604B2 (ja) * 2020-07-10 2024-09-26 範恩柯爾生物科技（中山）有限公司 トリアジン系化合物およびその組成物と用途
CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
EP4371978A4 (en) * 2021-07-13 2025-09-10 Nippon Soda Co PROCESS FOR PRODUCING A URACIL COMPOUND

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019510043A (ja) 2016-03-28 2019-04-11 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｔａｍ阻害剤としてのピロロトリアジン化合物
JP2021529765A (ja) 2018-06-29 2021-11-04 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ａｘｌ／ｍｅｒ阻害剤の製剤

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