RS54738B1 - Agensi koji vrše reverziju antikoagulanta - Google Patents

Agensi koji vrše reverziju antikoagulanta

Info

Publication number
RS54738B1
RS54738B1 RS20160318A RSP20160318A RS54738B1 RS 54738 B1 RS54738 B1 RS 54738B1 RS 20160318 A RS20160318 A RS 20160318A RS P20160318 A RSP20160318 A RS P20160318A RS 54738 B1 RS54738 B1 RS 54738B1
Authority
RS
Serbia
Prior art keywords
reversal agents
anticoagulant reversal
anticoagulant
substituted
alkylene chain
Prior art date
Application number
RS20160318A
Other languages
English (en)
Inventor
Solomon S Steiner
Bryan E Laulicht
Sasha H Bakhru
Edith Mathiowitz
Original Assignee
Perosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere Inc filed Critical Perosphere Inc
Publication of RS54738B1 publication Critical patent/RS54738B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Jedinjenje formule II: ili njegova farmaceutski prihvatljiva so;gde su i L i L' supstituisani ili nesupstituisani C1 do C10 alkilen lanac,gde su i M i M' supstituisani C1 do C10 alkilen lanac i gde su i Y i Y'Prijava sadrži još 22 patentna zahteva.
RS20160318A 2011-11-29 2012-11-29 Agensi koji vrše reverziju antikoagulanta RS54738B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161564559P 2011-11-29 2011-11-29
US201261614292P 2012-03-22 2012-03-22
US201261641698P 2012-05-02 2012-05-02
US201261666291P 2012-06-29 2012-06-29
EP12806229.6A EP2785700B1 (en) 2011-11-29 2012-11-29 Anticoagulant reversal agents
PCT/US2012/066938 WO2013082210A1 (en) 2011-11-29 2012-11-29 Anticoagulant reversal agents

Publications (1)

Publication Number Publication Date
RS54738B1 true RS54738B1 (sr) 2016-10-31

Family

ID=47430065

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20160318A RS54738B1 (sr) 2011-11-29 2012-11-29 Agensi koji vrše reverziju antikoagulanta

Country Status (35)

Country Link
US (4) US9522892B2 (sr)
EP (1) EP2785700B1 (sr)
JP (1) JP6134731B2 (sr)
KR (1) KR101892330B1 (sr)
CN (1) CN104080772B (sr)
AP (1) AP2014007662A0 (sr)
AR (1) AR089020A1 (sr)
AU (1) AU2012345975B2 (sr)
BR (1) BR112014012892B1 (sr)
CA (1) CA2856540C (sr)
CL (1) CL2014001399A1 (sr)
CO (1) CO6990738A2 (sr)
CR (1) CR20140310A (sr)
CY (1) CY1117414T1 (sr)
DK (1) DK2785700T3 (sr)
EA (1) EA027603B1 (sr)
EC (1) ECSP14006696A (sr)
ES (1) ES2569674T3 (sr)
HK (1) HK1202858A1 (sr)
HR (1) HRP20160513T1 (sr)
HU (1) HUE027452T2 (sr)
IL (1) IL232788B (sr)
ME (1) ME02424B (sr)
MX (1) MX349514B (sr)
PE (1) PE20141295A1 (sr)
PH (1) PH12014501176A1 (sr)
PL (1) PL2785700T3 (sr)
PT (1) PT2785700E (sr)
RS (1) RS54738B1 (sr)
SG (1) SG11201402713WA (sr)
SI (1) SI2785700T1 (sr)
SM (1) SMT201600161B (sr)
UA (1) UA116336C2 (sr)
WO (1) WO2013082210A1 (sr)
ZA (1) ZA201404793B (sr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9999690B2 (en) 2013-11-08 2018-06-19 Perosphere Pharmaceuticals Inc. Labeled compounds and methods of imaging, diagnosing cartilage disorders and diseases, and monitoring cartilage health using labeled and unlabeled compounds
BR112019027735A8 (pt) * 2017-11-13 2020-10-13 Maximum Fidelity Surgical Simulations Llc reconstituição de circulação pós-morte, métodos e procedimentos especializados
MX2021000127A (es) 2018-06-29 2021-03-29 Incyte Corp Formulaciones de un inhibidor de axl/mer.
US11716989B2 (en) 2019-04-16 2023-08-08 Maximum Fidelity Surgical Simulations, LLC Cadaver preservation systems and methods
US11915610B2 (en) 2019-05-15 2024-02-27 Maximum Fidelity Surgical Simulations, LLC Cadaverous heart model
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用

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IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US6080852A (en) 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
WO1998016547A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2285454A1 (en) * 1997-04-07 1998-10-15 Axys Pharmaceuticals Corporation Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity
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EP1058549A4 (en) * 1998-12-23 2003-11-12 Bristol Myers Squibb Pharma Co FACTOR Xa OR THROMBIN INHIBITORS
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EP1377554A1 (en) * 1999-06-16 2004-01-07 University Of Iowa Research Foundation Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
JP2004501077A (ja) 2000-04-17 2004-01-15 ファルマシア・コーポレーション 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン
CA2413241A1 (en) * 2000-06-29 2002-01-10 Bristol-Myers Squibb Pharma Company Thrombin or factor xa inhibitors
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AU2003217028A1 (en) * 2002-03-27 2003-10-13 Cambridge University Technical Services Ltd Diaminoacid-aminoacid-polyamine based gemini surfactant compounds
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GB0214122D0 (en) * 2002-06-19 2002-07-31 Eastman Kodak Co High contrast photographic element containing a polyhydrazide nucleating agent
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ES2849426T3 (es) * 2007-09-28 2021-08-18 Alexion Pharma Inc Antídotos para inhibidores del factor Xa y procedimientos de uso de los mismos
GB2476643B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑
WO2012130834A1 (en) 2011-03-30 2012-10-04 Boehringer Ingelheim International Gmbh Anticoagulant antidotes

Also Published As

Publication number Publication date
AR089020A1 (es) 2014-07-23
CL2014001399A1 (es) 2014-11-03
KR101892330B1 (ko) 2018-08-27
CA2856540C (en) 2018-04-03
BR112014012892A2 (pt) 2017-06-13
CN104080772A (zh) 2014-10-01
BR112014012892A8 (pt) 2021-06-08
KR20140107259A (ko) 2014-09-04
US9522892B2 (en) 2016-12-20
EA201490823A1 (ru) 2015-01-30
PL2785700T3 (pl) 2016-09-30
UA116336C2 (uk) 2018-03-12
CO6990738A2 (es) 2014-07-10
MX2014006349A (es) 2014-09-04
ECSP14006696A (es) 2015-06-30
NZ625337A (en) 2016-11-25
US20170056396A1 (en) 2017-03-02
BR112014012892B1 (pt) 2022-12-20
CR20140310A (es) 2014-08-20
EP2785700A1 (en) 2014-10-08
PT2785700E (pt) 2016-06-02
JP6134731B2 (ja) 2017-05-24
DK2785700T3 (en) 2016-06-13
CY1117414T1 (el) 2017-04-26
AU2012345975B2 (en) 2016-12-15
HK1202858A1 (en) 2015-10-09
US20180207152A1 (en) 2018-07-26
EA027603B1 (ru) 2017-08-31
SG11201402713WA (en) 2014-06-27
US20210169874A1 (en) 2021-06-10
IL232788A0 (en) 2014-08-03
CA2856540A1 (en) 2013-06-06
US20130137702A1 (en) 2013-05-30
MX349514B (es) 2017-08-02
PH12014501176B1 (en) 2014-09-01
ZA201404793B (en) 2015-04-29
PH12014501176A1 (en) 2014-09-01
HRP20160513T1 (hr) 2016-07-15
PE20141295A1 (es) 2014-10-01
IL232788B (en) 2018-05-31
CN104080772B (zh) 2016-10-05
WO2013082210A1 (en) 2013-06-06
ME02424B (me) 2016-09-20
JP2014534270A (ja) 2014-12-18
SI2785700T1 (sl) 2016-09-30
EP2785700B1 (en) 2016-03-09
AU2012345975A1 (en) 2014-05-29
ES2569674T3 (es) 2016-05-12
US9877961B2 (en) 2018-01-30
HUE027452T2 (en) 2016-09-28
SMT201600161B (it) 2016-07-01
AP2014007662A0 (en) 2014-05-31

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