AR089020A1 - Agentes de reversion anticoagulante - Google Patents

Agentes de reversion anticoagulante

Info

Publication number
AR089020A1
AR089020A1 ARP120104474A ARP120104474A AR089020A1 AR 089020 A1 AR089020 A1 AR 089020A1 AR P120104474 A ARP120104474 A AR P120104474A AR P120104474 A ARP120104474 A AR P120104474A AR 089020 A1 AR089020 A1 AR 089020A1
Authority
AR
Argentina
Prior art keywords
different
same
compound
anticoagulating
absent
Prior art date
Application number
ARP120104474A
Other languages
English (en)
Inventor
E Laulicht Bryan
H Bakhru Sasha
Mathiowitz Edith
S Steiner Solomon
Original Assignee
Perosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere Inc filed Critical Perosphere Inc
Publication of AR089020A1 publication Critical patent/AR089020A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Reivindicación 1: Un compuesto de la fórmula (1): Y-M-X-L-A-L-X-M-Y (1) o una sal farmacéuticamente aceptable de la misma, donde: A es un anillo carbocíclico o heterocíclico, aromático o no aromático, sustituido o no sustituido o un resto lineal; L y L son iguales o diferentes y son enlaces; X y X son iguales o diferentes y están ausentes o son un grupo funcional que une el enlace L a M y el enlace L a M, respectivamente; M y M son iguales o diferentes y están ausentes o son un enlace que une X a Y y X a Y, respectivamente; e Y e Y son iguales o diferentes y son un resto que contiene uno o más átomos o grupos catiónicos o uno o más grupos que se vuelven catiónicos en condiciones fisiológicas. Reivindicación 6: El compuesto de la reivindicación 1, donde el compuesto está representado por la fórmula (2) o una sal farmacéuticamente aceptable de este.
ARP120104474A 2011-11-29 2012-11-29 Agentes de reversion anticoagulante AR089020A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161564559P 2011-11-29 2011-11-29
US201261614292P 2012-03-22 2012-03-22
US201261641698P 2012-05-02 2012-05-02
US201261666291P 2012-06-29 2012-06-29

Publications (1)

Publication Number Publication Date
AR089020A1 true AR089020A1 (es) 2014-07-23

Family

ID=47430065

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104474A AR089020A1 (es) 2011-11-29 2012-11-29 Agentes de reversion anticoagulante

Country Status (35)

Country Link
US (4) US9522892B2 (es)
EP (1) EP2785700B1 (es)
JP (1) JP6134731B2 (es)
KR (1) KR101892330B1 (es)
CN (1) CN104080772B (es)
AP (1) AP2014007662A0 (es)
AR (1) AR089020A1 (es)
AU (1) AU2012345975B2 (es)
BR (1) BR112014012892B1 (es)
CA (1) CA2856540C (es)
CL (1) CL2014001399A1 (es)
CO (1) CO6990738A2 (es)
CR (1) CR20140310A (es)
CY (1) CY1117414T1 (es)
DK (1) DK2785700T3 (es)
EA (1) EA027603B1 (es)
EC (1) ECSP14006696A (es)
ES (1) ES2569674T3 (es)
HK (1) HK1202858A1 (es)
HR (1) HRP20160513T1 (es)
HU (1) HUE027452T2 (es)
IL (1) IL232788B (es)
ME (1) ME02424B (es)
MX (1) MX349514B (es)
PE (1) PE20141295A1 (es)
PH (1) PH12014501176A1 (es)
PL (1) PL2785700T3 (es)
PT (1) PT2785700E (es)
RS (1) RS54738B1 (es)
SG (1) SG11201402713WA (es)
SI (1) SI2785700T1 (es)
SM (1) SMT201600161B (es)
UA (1) UA116336C2 (es)
WO (1) WO2013082210A1 (es)
ZA (1) ZA201404793B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9999690B2 (en) 2013-11-08 2018-06-19 Perosphere Pharmaceuticals Inc. Labeled compounds and methods of imaging, diagnosing cartilage disorders and diseases, and monitoring cartilage health using labeled and unlabeled compounds
BR112019027735A8 (pt) * 2017-11-13 2020-10-13 Maximum Fidelity Surgical Simulations Llc reconstituição de circulação pós-morte, métodos e procedimentos especializados
MX2021000127A (es) 2018-06-29 2021-03-29 Incyte Corp Formulaciones de un inhibidor de axl/mer.
US11716989B2 (en) 2019-04-16 2023-08-08 Maximum Fidelity Surgical Simulations, LLC Cadaver preservation systems and methods
US11915610B2 (en) 2019-05-15 2024-02-27 Maximum Fidelity Surgical Simulations, LLC Cadaverous heart model
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用

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IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
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US6080852A (en) 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
WO1998016547A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2285454A1 (en) * 1997-04-07 1998-10-15 Axys Pharmaceuticals Corporation Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity
FR2781221B1 (fr) * 1998-07-17 2000-10-13 Lafon Labor Piperazinones substituees en alpha
EP1058549A4 (en) * 1998-12-23 2003-11-12 Bristol Myers Squibb Pharma Co FACTOR Xa OR THROMBIN INHIBITORS
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JP2004501077A (ja) 2000-04-17 2004-01-15 ファルマシア・コーポレーション 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン
CA2413241A1 (en) * 2000-06-29 2002-01-10 Bristol-Myers Squibb Pharma Company Thrombin or factor xa inhibitors
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AU2003217028A1 (en) * 2002-03-27 2003-10-13 Cambridge University Technical Services Ltd Diaminoacid-aminoacid-polyamine based gemini surfactant compounds
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ES2849426T3 (es) * 2007-09-28 2021-08-18 Alexion Pharma Inc Antídotos para inhibidores del factor Xa y procedimientos de uso de los mismos
GB2476643B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
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WO2012130834A1 (en) 2011-03-30 2012-10-04 Boehringer Ingelheim International Gmbh Anticoagulant antidotes

Also Published As

Publication number Publication date
CL2014001399A1 (es) 2014-11-03
KR101892330B1 (ko) 2018-08-27
CA2856540C (en) 2018-04-03
BR112014012892A2 (pt) 2017-06-13
CN104080772A (zh) 2014-10-01
BR112014012892A8 (pt) 2021-06-08
KR20140107259A (ko) 2014-09-04
US9522892B2 (en) 2016-12-20
EA201490823A1 (ru) 2015-01-30
PL2785700T3 (pl) 2016-09-30
UA116336C2 (uk) 2018-03-12
CO6990738A2 (es) 2014-07-10
MX2014006349A (es) 2014-09-04
ECSP14006696A (es) 2015-06-30
NZ625337A (en) 2016-11-25
US20170056396A1 (en) 2017-03-02
BR112014012892B1 (pt) 2022-12-20
CR20140310A (es) 2014-08-20
EP2785700A1 (en) 2014-10-08
PT2785700E (pt) 2016-06-02
JP6134731B2 (ja) 2017-05-24
DK2785700T3 (en) 2016-06-13
CY1117414T1 (el) 2017-04-26
AU2012345975B2 (en) 2016-12-15
HK1202858A1 (en) 2015-10-09
US20180207152A1 (en) 2018-07-26
EA027603B1 (ru) 2017-08-31
SG11201402713WA (en) 2014-06-27
US20210169874A1 (en) 2021-06-10
IL232788A0 (en) 2014-08-03
CA2856540A1 (en) 2013-06-06
US20130137702A1 (en) 2013-05-30
MX349514B (es) 2017-08-02
PH12014501176B1 (en) 2014-09-01
ZA201404793B (en) 2015-04-29
PH12014501176A1 (en) 2014-09-01
HRP20160513T1 (hr) 2016-07-15
PE20141295A1 (es) 2014-10-01
IL232788B (en) 2018-05-31
CN104080772B (zh) 2016-10-05
WO2013082210A1 (en) 2013-06-06
ME02424B (me) 2016-09-20
JP2014534270A (ja) 2014-12-18
RS54738B1 (sr) 2016-10-31
SI2785700T1 (sl) 2016-09-30
EP2785700B1 (en) 2016-03-09
AU2012345975A1 (en) 2014-05-29
ES2569674T3 (es) 2016-05-12
US9877961B2 (en) 2018-01-30
HUE027452T2 (en) 2016-09-28
SMT201600161B (it) 2016-07-01
AP2014007662A0 (en) 2014-05-31

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