PE9398A1 - Mejora de la tolerancia de �-aminoacidos farmaceuticamente activos - Google Patents
Mejora de la tolerancia de �-aminoacidos farmaceuticamente activosInfo
- Publication number
- PE9398A1 PE9398A1 PE1996000543A PE00054396A PE9398A1 PE 9398 A1 PE9398 A1 PE 9398A1 PE 1996000543 A PE1996000543 A PE 1996000543A PE 00054396 A PE00054396 A PE 00054396A PE 9398 A1 PE9398 A1 PE 9398A1
- Authority
- PE
- Peru
- Prior art keywords
- amino acids
- alkyl
- aryl
- phenyl
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE REFIERE A LA MEZCLA DE AMINOACIDOS, QUE COMPRENDE: a) UN O-AMINOACIDO DE FORMULA (Ia), EN DONDE: R3 ES H, CICLOALQUILO C3-C8, ARILO C6-C10, O ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO; R4 ES H O JUNTO CON R3 FORMA UN RESTO -(CH2)3; R5 ES H; "X" ES OH, ARILOXI C6-C10, ALCOXI C1-C8 o NR7R8, EN DONDE: R7 Y R8 SON H, ALQUILO C1-C8 o FENILO; SIENDO PREFERENTEMENTE (Ia) ISOLEUCIL O ALANIL; Y b) UN CICLOPENTANO �-AMINOACIDO DE FORMULA (Ib), EN DONDE: R1 Y R2 SON H O FORMAN =CH2; R6 ES H, ALQUILO C1-C8 o FENILO; "Y" ES H, ALQUILO C1-C8 o ARILO; TAMBIEN SE REFIERE AL DIPEPTIDO QUE COMPRENDE (Ia) E (Ib) EN DONDE "X" E "Y" SON LA PORCION DEL ENLACE COVALENTE, Y A SU PROCEDIMIENTO DE PREPARACION, QUE COMPRENDE: 1) HACER REACCIONAR (Ib) EN DONDE: R6 E "Y" SON H, CON (Ia) EN DONDE: R5 ES R10; R10 ES UN GRUPO PROTECTOR AMINO; "X" ES R11; R11 ES UN GRUPO PROTECTOR ACTIVADOR (RADICAL ESTER DE LA HIDROXISUCCINILAMIDA) o R10 Y R11 JUNTOS SON -C(O)-O-; 2)ELIMINAR R10; 3) SI R6 ES H, SEPARAR LOS ESTEREOISOMEROS O FORMAR ESTERES. LOS �-AMINOACIDOS INHIBEN LA BIOSINTESIS PROTEICA. LA TOMA SIMULTANEA DE �-AMINOACIDOS Y AMINOACIDOS NATURALES ANTAGONIZANTES, COMO MEZCLA O COMO DIPEPTIDOS, DA LUGAR A LA DISMINUCION DE LOS EFECTOS SECUNDARIOS, MANTENIENDO AL MISMO TIEMPO LA EFICACIA ANTIMICOTICA CONTRA DERMATOFITOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19526274A DE19526274A1 (de) | 1995-07-19 | 1995-07-19 | Verbesserung der Verträglichkeit von pharmazeutisch wirksamen beta-Aminosäuren |
Publications (1)
Publication Number | Publication Date |
---|---|
PE9398A1 true PE9398A1 (es) | 1998-04-15 |
Family
ID=7767189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1996000543A PE9398A1 (es) | 1995-07-19 | 1996-07-18 | Mejora de la tolerancia de �-aminoacidos farmaceuticamente activos |
Country Status (45)
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6191306B1 (en) * | 1999-08-03 | 2001-02-20 | Eastman Chemical Company | Process for the preparation of cyclopropylglycine |
KR20010073441A (ko) * | 2000-01-14 | 2001-08-01 | 최인도 | 패류종묘 착상판의 제조방법 |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7659253B2 (en) * | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
NZ544162A (en) * | 2003-05-29 | 2008-09-26 | Shire Llc | Abuse resistant amphetamine compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8716278D0 (en) * | 1987-07-10 | 1987-08-19 | Fujisawa Pharmaceutical Co | Antimicrobial agent |
JPH02174753A (ja) * | 1988-08-25 | 1990-07-06 | Fujisawa Pharmaceut Co Ltd | シス―2―アミノシクロペンタンカルボン酸誘導体およびその製法ならびに抗菌剤 |
DE4302155A1 (de) * | 1993-01-27 | 1994-07-28 | Bayer Ag | Verwendung von Cyclopentan- und -penten-beta-Aminosäuren |
US5631291A (en) * | 1992-05-29 | 1997-05-20 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-β-amino acids |
AU673824B2 (en) * | 1992-05-29 | 1996-11-28 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-beta-amino acids |
GB9216441D0 (en) * | 1992-08-03 | 1992-09-16 | Ici Plc | Fungicidal process |
WO1995007022A1 (en) * | 1993-09-07 | 1995-03-16 | Zeneca Limited | Fungicides |
DE19548825C2 (de) * | 1995-12-27 | 1999-03-25 | Rolf Dr Hermann | Neue, substituierte Cyclopentylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE19604225A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Stoffzusammensetzungen aus alpha-Aminosäuren und Cyclohexen-beta-aminosäuren |
-
1995
- 1995-07-19 DE DE19526274A patent/DE19526274A1/de not_active Withdrawn
-
1996
- 1996-06-28 HR HR960303A patent/HRP960303B1/xx not_active IP Right Cessation
- 1996-07-08 AT AT00110958T patent/ATE344274T1/de not_active IP Right Cessation
- 1996-07-08 DE DE59611398T patent/DE59611398D1/de not_active Expired - Fee Related
- 1996-07-08 DK DK00110958T patent/DK1043332T3/da active
- 1996-07-08 ES ES00110958T patent/ES2275460T3/es not_active Expired - Lifetime
- 1996-07-08 AT AT96110967T patent/ATE198469T1/de not_active IP Right Cessation
- 1996-07-08 ES ES96110967T patent/ES2154761T3/es not_active Expired - Lifetime
- 1996-07-08 DE DE59606266T patent/DE59606266D1/de not_active Expired - Fee Related
- 1996-07-08 SI SI9630243T patent/SI0754678T1/xx unknown
- 1996-07-08 PT PT96110967T patent/PT754678E/pt unknown
- 1996-07-08 DK DK96110967T patent/DK0754678T3/da active
- 1996-07-08 SI SI9630749T patent/SI1043332T1/sl unknown
- 1996-07-08 PT PT00110958T patent/PT1043332E/pt unknown
- 1996-07-08 EP EP96110967A patent/EP0754678B1/de not_active Expired - Lifetime
- 1996-07-08 EP EP00110958A patent/EP1043332B1/de not_active Expired - Lifetime
- 1996-07-12 YU YU20050685A patent/YU20050685A/sh unknown
- 1996-07-12 RS YU41796A patent/RS49520B/sr unknown
- 1996-07-12 US US08/679,027 patent/US5935988A/en not_active Expired - Fee Related
- 1996-07-12 AU AU59488/96A patent/AU713555B2/en not_active Ceased
- 1996-07-12 CU CU1996063A patent/CU22820A3/es unknown
- 1996-07-16 IL IL11886996A patent/IL118869A/en not_active IP Right Cessation
- 1996-07-16 TR TR96/00583A patent/TR199600583A2/xx unknown
- 1996-07-16 TW TW085108582A patent/TW496737B/zh not_active IP Right Cessation
- 1996-07-16 MA MA24315A patent/MA23940A1/fr unknown
- 1996-07-16 RO RO96-01451A patent/RO118656B1/ro unknown
- 1996-07-16 CA CA002181308A patent/CA2181308A1/en not_active Abandoned
- 1996-07-16 NZ NZ299008A patent/NZ299008A/en unknown
- 1996-07-17 SG SG1996010277A patent/SG47158A1/en unknown
- 1996-07-17 BG BG100716A patent/BG62134B1/bg unknown
- 1996-07-17 DZ DZ960117A patent/DZ2073A1/fr active
- 1996-07-17 UA UA96072884A patent/UA46725C2/uk unknown
- 1996-07-18 JP JP20641096A patent/JP3891503B2/ja not_active Expired - Fee Related
- 1996-07-18 KR KR1019960028961A patent/KR100433968B1/ko not_active IP Right Cessation
- 1996-07-18 MX MX9602836A patent/MX9602836A/es not_active IP Right Cessation
- 1996-07-18 SK SK947-96A patent/SK281850B6/sk unknown
- 1996-07-18 BR BR9603124A patent/BR9603124A/pt active Search and Examination
- 1996-07-18 NO NO19963000A patent/NO315926B1/no unknown
- 1996-07-18 PE PE1996000543A patent/PE9398A1/es not_active Application Discontinuation
- 1996-07-18 ZA ZA9606111A patent/ZA966111B/xx unknown
- 1996-07-18 EE EE9600109A patent/EE03803B1/xx not_active IP Right Cessation
- 1996-07-18 PL PL96315330A patent/PL184861B1/pl not_active IP Right Cessation
- 1996-07-18 TN TNTNSN96100A patent/TNSN96100A1/fr unknown
- 1996-07-18 CO CO96037937A patent/CO4700525A1/es unknown
- 1996-07-18 CZ CZ19962143A patent/CZ287896B6/cs not_active IP Right Cessation
- 1996-07-18 SK SK1421-2000A patent/SK284733B6/sk unknown
- 1996-07-19 SV SV1996000062A patent/SV1996000062A/es not_active Application Discontinuation
- 1996-07-19 RU RU96115341/04A patent/RU2181123C2/ru not_active IP Right Cessation
- 1996-07-19 AR ARP960103667A patent/AR003465A1/es unknown
- 1996-07-19 HU HU9601977A patent/HUP9601977A3/hu unknown
- 1996-07-19 CN CN96108880A patent/CN1115145C/zh not_active Expired - Fee Related
- 1996-12-11 SA SA96170491A patent/SA96170491B1/ar unknown
-
1998
- 1998-05-18 HK HK98104267A patent/HK1005131A1/xx not_active IP Right Cessation
-
2000
- 2000-07-10 CZ CZ20002554A patent/CZ288204B6/cs not_active IP Right Cessation
-
2001
- 2001-03-20 GR GR20010400447T patent/GR3035601T3/el not_active IP Right Cessation
-
2006
- 2006-09-27 JP JP2006263475A patent/JP2007056026A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |