PE20020610A1 - Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih - Google Patents

Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih

Info

Publication number
PE20020610A1
PE20020610A1 PE2001001170A PE2001001170A PE20020610A1 PE 20020610 A1 PE20020610 A1 PE 20020610A1 PE 2001001170 A PE2001001170 A PE 2001001170A PE 2001001170 A PE2001001170 A PE 2001001170A PE 20020610 A1 PE20020610 A1 PE 20020610A1
Authority
PE
Peru
Prior art keywords
alkyl
aspartile
tripeptide
mimetic
hiv
Prior art date
Application number
PE2001001170A
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Sally Redshaw
Steven Swallow
Gareth John Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20020610A1 publication Critical patent/PE20020610A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS HIDROXIETILAMINA TRIPEPTIDOS MIMETICOS DE FORMULA I DONDE R1 ES H, OH, NHR2 DONDE R2 ES H, ALQUILO, ALQUENILO, ALQUINILO, ARILALQUILO, HETEROCICLILALQUILO, CICLOALQUIL ALQUIL CARBONILO, ENTRE OTROS; R3 Y R4 SON ALQUILO O JUNTO AL CARBONO AL QUE ESTAN UNIDOS FORMAN UN CARBOCICLO; R5 ES ALQUIL, ARIL ALQUILO HETEROCICLIL ALQUILO; R4 Y R5 JUNTO A C Y S AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO; R6 ES ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO, ENTRE OTROS; R13 ES UN ESTER INORGANICO U ORGANICO; R15 ES ARILO. SON COMPUESTOS PREFERIDOS 2-[3(S)-[[N-BENZOIL-3-(METANOSULFONIL)-L-VALIL]-AMINO]-2(R)-HIDROXI-4-FENILBUTIL]-N-BENCIL-1,2,3,4,4a(S),5,6,7,8,8a(S)-DECAHIDRO-3(S)-ISOQUINOLINA-CARBOXAMIDA, N-TERC-BUTIL-2-[3(S)-[[N-[(9-FLUORFENI)-METOXI-CARBONIL]-3-(METANO-SULFONIL)-L-VALIL]-AMINO]-2(R)-HIDROXI-4-FENILBUTIL]-1,2,3,4,4a(S),5,6,7,8,8a(S)-DECAHIDRO-3(S)-ISOQUINOLINA-CARBOXAMIDA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA ASPARTIL PROTEASA DE VIH.
PE2001001170A 2000-11-22 2001-11-22 Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih PE20020610A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0028483.6A GB0028483D0 (en) 2000-11-22 2000-11-22 Hydroxyethylamine HIV protease inhibitors

Publications (1)

Publication Number Publication Date
PE20020610A1 true PE20020610A1 (es) 2002-07-13

Family

ID=9903670

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001170A PE20020610A1 (es) 2000-11-22 2001-11-22 Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih

Country Status (27)

Country Link
US (1) US6472404B1 (es)
EP (1) EP1339692A1 (es)
JP (1) JP2004520283A (es)
KR (1) KR20030060953A (es)
CN (1) CN1476436A (es)
AR (1) AR031763A1 (es)
AU (2) AU2954602A (es)
BG (1) BG107839A (es)
BR (1) BR0115566A (es)
CA (1) CA2428459A1 (es)
CZ (1) CZ20031667A3 (es)
EC (1) ECSP034618A (es)
GB (1) GB0028483D0 (es)
GT (1) GT200100233A (es)
HU (1) HUP0303007A2 (es)
IL (1) IL155573A0 (es)
MA (1) MA26966A1 (es)
MX (1) MXPA03004534A (es)
NO (1) NO20032290D0 (es)
NZ (1) NZ525550A (es)
PA (1) PA8533401A1 (es)
PE (1) PE20020610A1 (es)
PL (1) PL366704A1 (es)
RU (1) RU2265016C2 (es)
SK (1) SK7602003A3 (es)
UY (1) UY27033A1 (es)
WO (1) WO2002042277A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014572B (zh) * 2004-09-15 2011-07-06 盐野义制药株式会社 具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
MY161992A (en) * 2008-03-26 2017-05-31 Daiichi Sankyo Co Ltd Novel tetrahydroisoquinoline derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927913D0 (en) 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.

Also Published As

Publication number Publication date
NO20032290L (no) 2003-05-21
BG107839A (bg) 2004-06-30
NO20032290D0 (no) 2003-05-21
RU2003117468A (ru) 2005-01-27
BR0115566A (pt) 2003-09-30
MXPA03004534A (es) 2003-09-10
RU2265016C2 (ru) 2005-11-27
GT200100233A (es) 2002-07-04
EP1339692A1 (en) 2003-09-03
AR031763A1 (es) 2003-10-01
CZ20031667A3 (cs) 2004-01-14
PA8533401A1 (es) 2002-10-31
WO2002042277A1 (en) 2002-05-30
CA2428459A1 (en) 2002-05-30
SK7602003A3 (en) 2004-01-08
GB0028483D0 (en) 2001-01-10
HUP0303007A2 (hu) 2003-12-29
MA26966A1 (fr) 2004-12-20
KR20030060953A (ko) 2003-07-16
AU2954602A (en) 2002-06-03
ECSP034618A (es) 2003-06-25
JP2004520283A (ja) 2004-07-08
CN1476436A (zh) 2004-02-18
PL366704A1 (en) 2005-02-07
US6472404B1 (en) 2002-10-29
NZ525550A (en) 2004-11-26
IL155573A0 (en) 2003-11-23
AU2002229546B2 (en) 2006-05-04
UY27033A1 (es) 2002-06-20

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