PA8533401A1 - Inhibidores de la proteasa hidroxietilamina del vih - Google Patents

Inhibidores de la proteasa hidroxietilamina del vih

Info

Publication number
PA8533401A1
PA8533401A1 PA20018533401A PA8533401A PA8533401A1 PA 8533401 A1 PA8533401 A1 PA 8533401A1 PA 20018533401 A PA20018533401 A PA 20018533401A PA 8533401 A PA8533401 A PA 8533401A PA 8533401 A1 PA8533401 A1 PA 8533401A1
Authority
PA
Panama
Prior art keywords
rent
carbon
aril
heterociclyl
heterociclil
Prior art date
Application number
PA20018533401A
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Sally Redshaw
Steven Swallow
Gareth John Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8533401A1 publication Critical patent/PA8533401A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REVELAN LOS COMPUESTOS DE LA FORMULA GENERAL I; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS EN DONDE R1 ES H, HIDROXILO o NHR2 EN DONDE R2 ES H, ALQUILO, ALQUENILO, ALQUINILO, ARILALQUILO, HETEROCICLILALQUILO, CICLOALQUILO, ALQUIL CARBONILO, CICLOALQUIL CARBONILO, ARIL CARBONILO, HETEROCICLIL CARBONILO, ARIL ALQUIL CARBONILO, HETEROCICLIL ALQUIL CARBONILO, ALQUIL OXI CARBONILO, ARIL ALQUIL OXI CARBONILO, HETEROCICLIL ALQUIL OXI CARBONILO, ARILO, HETEROCICLILO, SULFONILO, AQUIL SULFONILO, ARIL SULFONILO, HETEROCICLIL SULFONILO o UN GRUPO DE FORMULA; EN DONDE X ES O ó S y R7 y R8 INDEPENDIENTEMENTE SON H, ALQUILO, ARILO, HETEROCICLILO, ARIL ALQUILO, HETEROCICLIL ALQUILO o R7 y R8 JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO SATURADO QUE OPCIONALMENTE CONTIENEN ADEMAS UN HETEROATOMO; o UN GRUPO EN DONDE CUANDO N=O, Y REPRESENTA O ó S y R10 ES H, ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO, ARILO, HETEROCICLILO o CUANDO N=1, Y REPRESENTA N, R9 ES H O ALQUILO Y R10 H, ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO. ARILO HETEROCICLILO o R9 y R10 JUNTO CON EL HETEROATOMO AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO, R11 y R12 INDEPENDIENTEMENTE SON H o ALQUILO o R11 y R12 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN CICLO, R3, R4 INDEPENDIENTEMENTE SON ALQUILO O JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN CARBOCICLO, R5 ES ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO o R4 y R5 JUNTO CON EL ATOMO DE CARBONO Y AZUFRE AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO y R6 ES ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO, ALQUIL OXI ALQUILO, HIDROXI ALQUILO, AMINO ALQUILO, FLUORO ALQUILO y R13 ES H o EL RESIDUO DE UN ESTER INORGANICO U ORGANICO y R15 ES ARILO, CON LA EXCEPCION QUE, SI R3, R4 y R5 SON METILO, R6 ES TERCBUTILO, R13 ES H y SI R15 ES FENILO R2 NO ES BENCIL OXICARBONILO NI 2-QUINOLINA CARBONILO. LOS COMPUESTOS DE FORMULA I SON POTENTES INHIBIDORES DE LA VIH ASPARTIL PROTEASA Y SE PUEDEN USAR EN EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON VIH
PA20018533401A 2000-11-22 2001-11-21 Inhibidores de la proteasa hidroxietilamina del vih PA8533401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0028483.6A GB0028483D0 (en) 2000-11-22 2000-11-22 Hydroxyethylamine HIV protease inhibitors

Publications (1)

Publication Number Publication Date
PA8533401A1 true PA8533401A1 (es) 2002-10-31

Family

ID=9903670

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018533401A PA8533401A1 (es) 2000-11-22 2001-11-21 Inhibidores de la proteasa hidroxietilamina del vih

Country Status (27)

Country Link
US (1) US6472404B1 (es)
EP (1) EP1339692A1 (es)
JP (1) JP2004520283A (es)
KR (1) KR20030060953A (es)
CN (1) CN1476436A (es)
AR (1) AR031763A1 (es)
AU (2) AU2954602A (es)
BG (1) BG107839A (es)
BR (1) BR0115566A (es)
CA (1) CA2428459A1 (es)
CZ (1) CZ20031667A3 (es)
EC (1) ECSP034618A (es)
GB (1) GB0028483D0 (es)
GT (1) GT200100233A (es)
HU (1) HUP0303007A2 (es)
IL (1) IL155573A0 (es)
MA (1) MA26966A1 (es)
MX (1) MXPA03004534A (es)
NO (1) NO20032290D0 (es)
NZ (1) NZ525550A (es)
PA (1) PA8533401A1 (es)
PE (1) PE20020610A1 (es)
PL (1) PL366704A1 (es)
RU (1) RU2265016C2 (es)
SK (1) SK7602003A3 (es)
UY (1) UY27033A1 (es)
WO (1) WO2002042277A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014572B (zh) * 2004-09-15 2011-07-06 盐野义制药株式会社 具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
MY161992A (en) * 2008-03-26 2017-05-31 Daiichi Sankyo Co Ltd Novel tetrahydroisoquinoline derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927913D0 (en) 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.

Also Published As

Publication number Publication date
NO20032290L (no) 2003-05-21
BG107839A (bg) 2004-06-30
NO20032290D0 (no) 2003-05-21
RU2003117468A (ru) 2005-01-27
BR0115566A (pt) 2003-09-30
MXPA03004534A (es) 2003-09-10
RU2265016C2 (ru) 2005-11-27
GT200100233A (es) 2002-07-04
EP1339692A1 (en) 2003-09-03
AR031763A1 (es) 2003-10-01
CZ20031667A3 (cs) 2004-01-14
WO2002042277A1 (en) 2002-05-30
CA2428459A1 (en) 2002-05-30
SK7602003A3 (en) 2004-01-08
GB0028483D0 (en) 2001-01-10
HUP0303007A2 (hu) 2003-12-29
MA26966A1 (fr) 2004-12-20
KR20030060953A (ko) 2003-07-16
AU2954602A (en) 2002-06-03
PE20020610A1 (es) 2002-07-13
ECSP034618A (es) 2003-06-25
JP2004520283A (ja) 2004-07-08
CN1476436A (zh) 2004-02-18
PL366704A1 (en) 2005-02-07
US6472404B1 (en) 2002-10-29
NZ525550A (en) 2004-11-26
IL155573A0 (en) 2003-11-23
AU2002229546B2 (en) 2006-05-04
UY27033A1 (es) 2002-06-20

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