BR0115566A - Compostos para emprego como inibidores de protease de hiv - Google Patents
Compostos para emprego como inibidores de protease de hivInfo
- Publication number
- BR0115566A BR0115566A BR0115566-0A BR0115566A BR0115566A BR 0115566 A BR0115566 A BR 0115566A BR 0115566 A BR0115566 A BR 0115566A BR 0115566 A BR0115566 A BR 0115566A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- compounds
- taken together
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS PARA EMPREGO COMO INIBIDORES DE PROTEASE DE HIV". São descritos compostos de fórmula geral (I) e sais farmaceuticamente aceitáveis destes, onde R^ 1^ é H, hidróxi ou NHR^ 2^, onde R^ 2^ é H, alquila, alquenila, alquinila, arilalquila, heterociclialquila, cicloalquila, alquil carbonila, cicloalquil carbonila, aril cabonila, heterociclil carbonila, aril alquil carbonila, heterociclil alquil carbonila, alquilóxi carbonila, aril alquilóxi carbonila, heterociclil alquilóxi carbonila, aril heterociclil sulfonila, alquil sulfonila, aril sulfonila, heterociclil sulfonila ou um grupo de fórmula (A), onde X é O ou S e R^ 7^ e R^ 8^ independentemente são H, alquila, arila, heterociclila, aril alquila, heterociclil alquila ou R^ 7^ e R^ 8^ juntamente com o átomo de nitrogênio ao qual eles são ligados formam um anel saturado opcionalmente contendo um outro heteroátomo ou um grupo (B), onde quando n=1, Y representa N, R^ 9^ é H ou alquila e R^ 10^ H, alquila, arila, alquila, heterociclila alquila, arila, heterociclila ou R^ 9^ e R^ 10^ tomados juntos com o heteroátomo ao qual eles são ligados formam um heterociclo, R^ 11^ e R^ 12^ independentemente são H ou alquila ou R^ 11^ e R^ 12^ tomados juntos com o átomo de carbono ao qual eles são ligados formam um ciclo, R^ 3^, R^ 4^ independentemente são alquila ou tomados juntos com o átomo de carbono ao qual eles são ligados formam um carbociclo, R^ 5^ é alquila, aril alquila, heterociclil alquila ou R^ 4^ e R^ 5^ tomados juntos com o átomo de enxofre e carbono ao qual eles são ligados formam um heterociclo e R^ 6^ é alquila, aril alquila, heterociclila alquila, alquilóxi alquila, hidróxi alquil, amino alquil, flúor alquil e R^ 13^ é H ou o resíduo de um éster inorgânico e R^ 15^ é arila, com a condição de que, se R^ 3^, R^ 4^ e R^ 5^ são metila, R^ 6^ é terc-butila, R^ 13^ é H e se R^ 15^ é fenila R^ 2^ não é benzil oxicarbonila e nem 2-quinolina carbonila. Os compostos de fórmula (I) são potentes inibidores da protease de aspartila de HIV e podem portanto ser empregados no tratamento de doenças relacionadas com HIV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028483.6A GB0028483D0 (en) | 2000-11-22 | 2000-11-22 | Hydroxyethylamine HIV protease inhibitors |
| PCT/EP2001/013068 WO2002042277A1 (en) | 2000-11-22 | 2001-11-12 | Novel compounds for use as hiv protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0115566A true BR0115566A (pt) | 2003-09-30 |
Family
ID=9903670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0115566-0A BR0115566A (pt) | 2000-11-22 | 2001-11-12 | Compostos para emprego como inibidores de protease de hiv |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6472404B1 (pt) |
| EP (1) | EP1339692A1 (pt) |
| JP (1) | JP2004520283A (pt) |
| KR (1) | KR20030060953A (pt) |
| CN (1) | CN1476436A (pt) |
| AR (1) | AR031763A1 (pt) |
| AU (2) | AU2954602A (pt) |
| BG (1) | BG107839A (pt) |
| BR (1) | BR0115566A (pt) |
| CA (1) | CA2428459A1 (pt) |
| CZ (1) | CZ20031667A3 (pt) |
| EC (1) | ECSP034618A (pt) |
| GB (1) | GB0028483D0 (pt) |
| GT (1) | GT200100233A (pt) |
| HU (1) | HUP0303007A2 (pt) |
| IL (1) | IL155573A0 (pt) |
| MA (1) | MA26966A1 (pt) |
| MX (1) | MXPA03004534A (pt) |
| NO (1) | NO20032290D0 (pt) |
| NZ (1) | NZ525550A (pt) |
| PA (1) | PA8533401A1 (pt) |
| PE (1) | PE20020610A1 (pt) |
| PL (1) | PL366704A1 (pt) |
| RU (1) | RU2265016C2 (pt) |
| SK (1) | SK7602003A3 (pt) |
| UY (1) | UY27033A1 (pt) |
| WO (1) | WO2002042277A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014572B (zh) * | 2004-09-15 | 2011-07-06 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物 |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| MY161992A (en) * | 2008-03-26 | 2017-05-31 | Daiichi Sankyo Co Ltd | Novel tetrahydroisoquinoline derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927913D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
-
2000
- 2000-11-22 GB GBGB0028483.6A patent/GB0028483D0/en not_active Ceased
-
2001
- 2001-11-12 AU AU2954602A patent/AU2954602A/xx active Pending
- 2001-11-12 NZ NZ525550A patent/NZ525550A/en unknown
- 2001-11-12 JP JP2002544412A patent/JP2004520283A/ja active Pending
- 2001-11-12 AU AU2002229546A patent/AU2002229546B2/en not_active Ceased
- 2001-11-12 BR BR0115566-0A patent/BR0115566A/pt not_active IP Right Cessation
- 2001-11-12 CN CNA018192890A patent/CN1476436A/zh active Pending
- 2001-11-12 WO PCT/EP2001/013068 patent/WO2002042277A1/en active IP Right Grant
- 2001-11-12 HU HU0303007A patent/HUP0303007A2/hu unknown
- 2001-11-12 SK SK760-2003A patent/SK7602003A3/sk unknown
- 2001-11-12 EP EP01990405A patent/EP1339692A1/en not_active Withdrawn
- 2001-11-12 RU RU2003117468/04A patent/RU2265016C2/ru not_active IP Right Cessation
- 2001-11-12 KR KR10-2003-7006907A patent/KR20030060953A/ko not_active Application Discontinuation
- 2001-11-12 CZ CZ20031667A patent/CZ20031667A3/cs unknown
- 2001-11-12 IL IL15557301A patent/IL155573A0/xx unknown
- 2001-11-12 CA CA002428459A patent/CA2428459A1/en not_active Abandoned
- 2001-11-12 PL PL01366704A patent/PL366704A1/xx not_active Application Discontinuation
- 2001-11-12 MX MXPA03004534A patent/MXPA03004534A/es active IP Right Grant
- 2001-11-20 US US09/999,082 patent/US6472404B1/en not_active Expired - Fee Related
- 2001-11-21 GT GT200100233A patent/GT200100233A/es unknown
- 2001-11-21 AR ARP010105431A patent/AR031763A1/es unknown
- 2001-11-21 UY UY27033A patent/UY27033A1/es not_active Application Discontinuation
- 2001-11-21 PA PA20018533401A patent/PA8533401A1/es unknown
- 2001-11-22 PE PE2001001170A patent/PE20020610A1/es not_active Application Discontinuation
-
2003
- 2003-05-21 NO NO20032290A patent/NO20032290D0/no unknown
- 2003-05-21 EC EC2003004618A patent/ECSP034618A/es unknown
- 2003-05-22 BG BG107839A patent/BG107839A/bg unknown
- 2003-05-22 MA MA27172A patent/MA26966A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20032290L (no) | 2003-05-21 |
| BG107839A (bg) | 2004-06-30 |
| NO20032290D0 (no) | 2003-05-21 |
| RU2003117468A (ru) | 2005-01-27 |
| MXPA03004534A (es) | 2003-09-10 |
| RU2265016C2 (ru) | 2005-11-27 |
| GT200100233A (es) | 2002-07-04 |
| EP1339692A1 (en) | 2003-09-03 |
| AR031763A1 (es) | 2003-10-01 |
| CZ20031667A3 (cs) | 2004-01-14 |
| PA8533401A1 (es) | 2002-10-31 |
| WO2002042277A1 (en) | 2002-05-30 |
| CA2428459A1 (en) | 2002-05-30 |
| SK7602003A3 (en) | 2004-01-08 |
| GB0028483D0 (en) | 2001-01-10 |
| HUP0303007A2 (hu) | 2003-12-29 |
| MA26966A1 (fr) | 2004-12-20 |
| KR20030060953A (ko) | 2003-07-16 |
| AU2954602A (en) | 2002-06-03 |
| PE20020610A1 (es) | 2002-07-13 |
| ECSP034618A (es) | 2003-06-25 |
| JP2004520283A (ja) | 2004-07-08 |
| CN1476436A (zh) | 2004-02-18 |
| PL366704A1 (en) | 2005-02-07 |
| US6472404B1 (en) | 2002-10-29 |
| NZ525550A (en) | 2004-11-26 |
| IL155573A0 (en) | 2003-11-23 |
| AU2002229546B2 (en) | 2006-05-04 |
| UY27033A1 (es) | 2002-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 8A, 9AE 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |