AR031763A1 - Nuevos compuestos para el uso como inhibidores de proteasas hiv - Google Patents
Nuevos compuestos para el uso como inhibidores de proteasas hivInfo
- Publication number
- AR031763A1 AR031763A1 ARP010105431A ARP010105431A AR031763A1 AR 031763 A1 AR031763 A1 AR 031763A1 AR P010105431 A ARP010105431 A AR P010105431A AR P010105431 A ARP010105431 A AR P010105431A AR 031763 A1 AR031763 A1 AR 031763A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- attached form
- heterocyclylalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se revelan los compuestos de la formula general (1) y las sales farmacéuticamente aceptables de los mismos en donde R1 es H, hidroxi o NHR2, en donde R2 es H, alquilo, alquenilo, alquinilo, arialquilo, heterociclilalquilo, cicloalquilo, alquilcarbonilo, cicloalquilcarbonilo, arialcarbonilo, heterociclilcarbonilo, arialquilcarbonilo, heterociclilalquilcarbonilo, alquiloxicarbonilo, arialquiloxicarbonilo, heterociclilalquiloxicarbonilo, arilo, heterociclilo, sulfonilo, alquilsulfonilo, arilsulfonilo, heterociclilsulfonilo o un grupo de formula (2), en donde X es O o S y R7 y R8 independientemente son H, alquilo, arilo, heterociclilo, arilalquilo, heterociclil alquilo o R7 y R8 junto con el átomo de nitrogeno al que están unidos forman un anillo saturado que opcionalmente contienen además un heteroátomo o un grupo de formula (3), en donde cuando n = 0, Y representa O o S y R10 es H, alquilo, arilalquilo, heterociclilalquilo, arilo, heterociclilo, o cuando n = 1, Y representa N, R9 es H o alquilo y R10 H, alquilo, arilalquilo, heterociclilalquilo, arilo, heterociclilo o R9 y R10 junto con el heteroátomo al que están unidos forman un heterociclo, R11 y R12 independientemente son H o alquilo o R11 y R12 junto con el átomo de carbono al que están unidos forman un ciclo; R3, R4 independientemente son alquilo o junto con el átomo de carbono al que están unidos forman un carbociclo; R5 es alquilo, arilalquilo, heterociclilalquilo o R4 y R5 junto con el átomo de carbono y azufre al están unidos forman un heterociclo y R6 es alquilo, aril alquilo, heterociclil alquilo, alquiloxialquilo, hidroxialquilo, aminoalquilo, fluoroalquilo y R13 es H o el residuo de un éster inorgánico u orgánico y R15 es arilo, con la condicion de que, si R3, R4 y R5 son metilo, R6 es tercbutilo, R13 es H y si R15 es fenilo R2 no es bencil oxicarbonilo ni 2-quinolinacarbonilo. Los compuestos de formula (1) son potentes inhibidores de la aspartil proteasa del HIV y se pueden usar en el tratamiento de enfermedades relacionadas con el HIV.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028483.6A GB0028483D0 (en) | 2000-11-22 | 2000-11-22 | Hydroxyethylamine HIV protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031763A1 true AR031763A1 (es) | 2003-10-01 |
Family
ID=9903670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105431A AR031763A1 (es) | 2000-11-22 | 2001-11-21 | Nuevos compuestos para el uso como inhibidores de proteasas hiv |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6472404B1 (es) |
| EP (1) | EP1339692A1 (es) |
| JP (1) | JP2004520283A (es) |
| KR (1) | KR20030060953A (es) |
| CN (1) | CN1476436A (es) |
| AR (1) | AR031763A1 (es) |
| AU (2) | AU2954602A (es) |
| BG (1) | BG107839A (es) |
| BR (1) | BR0115566A (es) |
| CA (1) | CA2428459A1 (es) |
| CZ (1) | CZ20031667A3 (es) |
| EC (1) | ECSP034618A (es) |
| GB (1) | GB0028483D0 (es) |
| GT (1) | GT200100233A (es) |
| HU (1) | HUP0303007A2 (es) |
| IL (1) | IL155573A0 (es) |
| MA (1) | MA26966A1 (es) |
| MX (1) | MXPA03004534A (es) |
| NO (1) | NO20032290D0 (es) |
| NZ (1) | NZ525550A (es) |
| PA (1) | PA8533401A1 (es) |
| PE (1) | PE20020610A1 (es) |
| PL (1) | PL366704A1 (es) |
| RU (1) | RU2265016C2 (es) |
| SK (1) | SK7602003A3 (es) |
| UY (1) | UY27033A1 (es) |
| WO (1) | WO2002042277A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101014572B (zh) * | 2004-09-15 | 2011-07-06 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物 |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| MY161992A (en) * | 2008-03-26 | 2017-05-31 | Daiichi Sankyo Co Ltd | Novel tetrahydroisoquinoline derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927913D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
-
2000
- 2000-11-22 GB GBGB0028483.6A patent/GB0028483D0/en not_active Ceased
-
2001
- 2001-11-12 AU AU2954602A patent/AU2954602A/xx active Pending
- 2001-11-12 NZ NZ525550A patent/NZ525550A/en unknown
- 2001-11-12 JP JP2002544412A patent/JP2004520283A/ja active Pending
- 2001-11-12 AU AU2002229546A patent/AU2002229546B2/en not_active Ceased
- 2001-11-12 BR BR0115566-0A patent/BR0115566A/pt not_active IP Right Cessation
- 2001-11-12 CN CNA018192890A patent/CN1476436A/zh active Pending
- 2001-11-12 WO PCT/EP2001/013068 patent/WO2002042277A1/en active IP Right Grant
- 2001-11-12 HU HU0303007A patent/HUP0303007A2/hu unknown
- 2001-11-12 SK SK760-2003A patent/SK7602003A3/sk unknown
- 2001-11-12 EP EP01990405A patent/EP1339692A1/en not_active Withdrawn
- 2001-11-12 RU RU2003117468/04A patent/RU2265016C2/ru not_active IP Right Cessation
- 2001-11-12 KR KR10-2003-7006907A patent/KR20030060953A/ko not_active Application Discontinuation
- 2001-11-12 CZ CZ20031667A patent/CZ20031667A3/cs unknown
- 2001-11-12 IL IL15557301A patent/IL155573A0/xx unknown
- 2001-11-12 CA CA002428459A patent/CA2428459A1/en not_active Abandoned
- 2001-11-12 PL PL01366704A patent/PL366704A1/xx not_active Application Discontinuation
- 2001-11-12 MX MXPA03004534A patent/MXPA03004534A/es active IP Right Grant
- 2001-11-20 US US09/999,082 patent/US6472404B1/en not_active Expired - Fee Related
- 2001-11-21 GT GT200100233A patent/GT200100233A/es unknown
- 2001-11-21 AR ARP010105431A patent/AR031763A1/es unknown
- 2001-11-21 UY UY27033A patent/UY27033A1/es not_active Application Discontinuation
- 2001-11-21 PA PA20018533401A patent/PA8533401A1/es unknown
- 2001-11-22 PE PE2001001170A patent/PE20020610A1/es not_active Application Discontinuation
-
2003
- 2003-05-21 NO NO20032290A patent/NO20032290D0/no unknown
- 2003-05-21 EC EC2003004618A patent/ECSP034618A/es unknown
- 2003-05-22 BG BG107839A patent/BG107839A/bg unknown
- 2003-05-22 MA MA27172A patent/MA26966A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20032290L (no) | 2003-05-21 |
| BG107839A (bg) | 2004-06-30 |
| NO20032290D0 (no) | 2003-05-21 |
| RU2003117468A (ru) | 2005-01-27 |
| BR0115566A (pt) | 2003-09-30 |
| MXPA03004534A (es) | 2003-09-10 |
| RU2265016C2 (ru) | 2005-11-27 |
| GT200100233A (es) | 2002-07-04 |
| EP1339692A1 (en) | 2003-09-03 |
| CZ20031667A3 (cs) | 2004-01-14 |
| PA8533401A1 (es) | 2002-10-31 |
| WO2002042277A1 (en) | 2002-05-30 |
| CA2428459A1 (en) | 2002-05-30 |
| SK7602003A3 (en) | 2004-01-08 |
| GB0028483D0 (en) | 2001-01-10 |
| HUP0303007A2 (hu) | 2003-12-29 |
| MA26966A1 (fr) | 2004-12-20 |
| KR20030060953A (ko) | 2003-07-16 |
| AU2954602A (en) | 2002-06-03 |
| PE20020610A1 (es) | 2002-07-13 |
| ECSP034618A (es) | 2003-06-25 |
| JP2004520283A (ja) | 2004-07-08 |
| CN1476436A (zh) | 2004-02-18 |
| PL366704A1 (en) | 2005-02-07 |
| US6472404B1 (en) | 2002-10-29 |
| NZ525550A (en) | 2004-11-26 |
| IL155573A0 (en) | 2003-11-23 |
| AU2002229546B2 (en) | 2006-05-04 |
| UY27033A1 (es) | 2002-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |