CO4700525A1 - Mezclas de -aminoacidos y ciclopentano- -aminoacidos y/o sus derivados, los cuales tienen tolerancia mejorada - Google Patents

Mezclas de -aminoacidos y ciclopentano- -aminoacidos y/o sus derivados, los cuales tienen tolerancia mejorada

Info

Publication number
CO4700525A1
CO4700525A1 CO96037937A CO96037937A CO4700525A1 CO 4700525 A1 CO4700525 A1 CO 4700525A1 CO 96037937 A CO96037937 A CO 96037937A CO 96037937 A CO96037937 A CO 96037937A CO 4700525 A1 CO4700525 A1 CO 4700525A1
Authority
CO
Colombia
Prior art keywords
amino acids
derivatives
cyclopentane
mixtures
improved tolerance
Prior art date
Application number
CO96037937A
Other languages
English (en)
Inventor
Michael Matzke
Hans-Christi Militzer
Joachim Mittendorf
Franz Kunisch
Axel Schmidt
Wolfgang Schonfeld
Karl Ziegelbauer
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CO4700525A1 publication Critical patent/CO4700525A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Mezcla que contiene uno o varios a-aminoácidos y/o susderivados y uno o varios ciclopentano-ß-aminoácidos y/o sus derivados. Mezcla de acuerdo con la reivindicación 1 ó 2, caracterizada porque contiene ciclopentano-ß-aminoácidos de fórmula general (Ib)en la queR1 y R2 son hidrógeno oR1 y R2 pueden formar conjuntamente un resto de fórmula =CH2 ,R6 es hidrógeno o alquilo de cadena lineal o ramificada de hasta 8 átomos de carbono o fenilo eY es hidrógeno, alquilo de cadena lineal o ramificada de hasta 8 átomos de carbono o arilo.
CO96037937A 1995-07-19 1996-07-18 Mezclas de -aminoacidos y ciclopentano- -aminoacidos y/o sus derivados, los cuales tienen tolerancia mejorada CO4700525A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19526274A DE19526274A1 (de) 1995-07-19 1995-07-19 Verbesserung der Verträglichkeit von pharmazeutisch wirksamen beta-Aminosäuren

Publications (1)

Publication Number Publication Date
CO4700525A1 true CO4700525A1 (es) 1998-12-29

Family

ID=7767189

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96037937A CO4700525A1 (es) 1995-07-19 1996-07-18 Mezclas de -aminoacidos y ciclopentano- -aminoacidos y/o sus derivados, los cuales tienen tolerancia mejorada

Country Status (45)

Country Link
US (1) US5935988A (es)
EP (2) EP0754678B1 (es)
JP (2) JP3891503B2 (es)
KR (1) KR100433968B1 (es)
CN (1) CN1115145C (es)
AR (1) AR003465A1 (es)
AT (2) ATE344274T1 (es)
AU (1) AU713555B2 (es)
BG (1) BG62134B1 (es)
BR (1) BR9603124A (es)
CA (1) CA2181308A1 (es)
CO (1) CO4700525A1 (es)
CU (1) CU22820A3 (es)
CZ (2) CZ287896B6 (es)
DE (3) DE19526274A1 (es)
DK (2) DK1043332T3 (es)
DZ (1) DZ2073A1 (es)
EE (1) EE03803B1 (es)
ES (2) ES2275460T3 (es)
GR (1) GR3035601T3 (es)
HK (1) HK1005131A1 (es)
HR (1) HRP960303B1 (es)
HU (1) HUP9601977A3 (es)
IL (1) IL118869A (es)
MA (1) MA23940A1 (es)
MX (1) MX9602836A (es)
NO (1) NO315926B1 (es)
NZ (1) NZ299008A (es)
PE (1) PE9398A1 (es)
PL (1) PL184861B1 (es)
PT (2) PT1043332E (es)
RO (1) RO118656B1 (es)
RS (1) RS49520B (es)
RU (1) RU2181123C2 (es)
SA (1) SA96170491B1 (es)
SG (1) SG47158A1 (es)
SI (2) SI0754678T1 (es)
SK (2) SK284733B6 (es)
SV (1) SV1996000062A (es)
TN (1) TNSN96100A1 (es)
TR (1) TR199600583A2 (es)
TW (1) TW496737B (es)
UA (1) UA46725C2 (es)
YU (1) YU20050685A (es)
ZA (1) ZA966111B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine
KR20010073441A (ko) * 2000-01-14 2001-08-01 최인도 패류종묘 착상판의 제조방법
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
PT1644019E (pt) * 2003-05-29 2012-05-23 Shire Llc Compostos de anfetamina resistentes ao abuso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716278D0 (en) * 1987-07-10 1987-08-19 Fujisawa Pharmaceutical Co Antimicrobial agent
JPH02174753A (ja) * 1988-08-25 1990-07-06 Fujisawa Pharmaceut Co Ltd シス―２―アミノシクロペンタンカルボン酸誘導体およびその製法ならびに抗菌剤
DE4302155A1 (de) * 1993-01-27 1994-07-28 Bayer Ag Verwendung von Cyclopentan- und -penten-beta-Aminosäuren
US5631291A (en) * 1992-05-29 1997-05-20 Bayer Aktiengesellschaft Cyclopentane- and -pentene-β-amino acids
AU673824B2 (en) * 1992-05-29 1996-11-28 Bayer Aktiengesellschaft Cyclopentane- and -pentene-beta-amino acids
GB9216441D0 (en) * 1992-08-03 1992-09-16 Ici Plc Fungicidal process
WO1995007022A1 (en) * 1993-09-07 1995-03-16 Zeneca Limited Fungicides
DE19548825C2 (de) * 1995-12-27 1999-03-25 Rolf Dr Hermann Neue, substituierte Cyclopentylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19604225A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Stoffzusammensetzungen aus alpha-Aminosäuren und Cyclohexen-beta-aminosäuren

Also Published As

Publication number Publication date
CN1115145C (zh) 2003-07-23
JPH09202761A (ja) 1997-08-05
EE03803B1 (et) 2002-08-15
ES2154761T3 (es) 2001-04-16
AU5948896A (en) 1997-01-23
MA23940A1 (fr) 1997-04-01
NO963000L (no) 1997-01-20
RU2181123C2 (ru) 2002-04-10
YU20050685A (sh) 2006-08-17
RO118656B1 (ro) 2003-08-29
CZ287896B6 (cs) 2001-03-14
BR9603124A (pt) 1998-04-22
TW496737B (en) 2002-08-01
US5935988A (en) 1999-08-10
IL118869A (en) 2002-03-10
GR3035601T3 (en) 2001-06-29
YU41796A (sh) 1999-06-15
SI1043332T1 (sl) 2007-04-30
MX9602836A (es) 1997-01-31
UA46725C2 (uk) 2002-06-17
TNSN96100A1 (fr) 2005-03-15
DZ2073A1 (fr) 2002-07-22
TR199600583A2 (tr) 1997-02-21
SK284733B6 (sk) 2005-10-06
EP1043332A1 (de) 2000-10-11
PL315330A1 (en) 1997-01-20
CA2181308A1 (en) 1997-01-20
CU22820A3 (es) 2003-01-29
DK0754678T3 (da) 2001-02-05
HUP9601977A2 (en) 1997-05-28
JP2007056026A (ja) 2007-03-08
AR003465A1 (es) 1998-08-05
CZ288204B6 (en) 2001-05-16
IL118869A0 (en) 1996-10-31
NO963000D0 (no) 1996-07-18
SA96170491B1 (ar) 2006-09-20
EE9600109A (et) 1997-02-17
JP3891503B2 (ja) 2007-03-14
ZA966111B (en) 1997-02-03
NO315926B1 (no) 2003-11-17
DK1043332T3 (da) 2007-03-12
EP1043332B1 (de) 2006-11-02
HRP960303B1 (en) 2001-08-31
DE59611398D1 (de) 2006-12-14
PL184861B1 (pl) 2003-01-31
SK281850B6 (sk) 2001-08-06
ATE344274T1 (de) 2006-11-15
EP0754678B1 (de) 2001-01-03
PT1043332E (pt) 2007-01-31
RS49520B (sr) 2006-10-27
KR970006312A (ko) 1997-02-19
PE9398A1 (es) 1998-04-15
EP0754678A3 (de) 1997-12-17
DE59606266D1 (de) 2001-02-08
PT754678E (pt) 2001-04-30
HRP960303A2 (en) 1998-02-28
SK94796A3 (en) 1997-02-05
ATE198469T1 (de) 2001-01-15
SG47158A1 (en) 1998-03-20
HK1005131A1 (en) 1998-12-24
BG100716A (bg) 1997-04-30
EP0754678A2 (de) 1997-01-22
HUP9601977A3 (en) 1998-04-28
SI0754678T1 (en) 2001-04-30
HU9601977D0 (en) 1996-09-30
CN1143496A (zh) 1997-02-26
NZ299008A (en) 1998-05-27
CZ214396A3 (en) 1997-02-12
BG62134B1 (bg) 1999-03-31
DE19526274A1 (de) 1997-01-23
SV1996000062A (es) 1997-06-26
AU713555B2 (en) 1999-12-02
ES2275460T3 (es) 2007-06-16
KR100433968B1 (ko) 2004-08-30

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