DE69633722D1 - Stoffwechseleffekt von bestimmten glutation analogen - Google Patents

Stoffwechseleffekt von bestimmten glutation analogen

Info

Publication number
DE69633722D1
DE69633722D1 DE69633722T DE69633722T DE69633722D1 DE 69633722 D1 DE69633722 D1 DE 69633722D1 DE 69633722 T DE69633722 T DE 69633722T DE 69633722 T DE69633722 T DE 69633722T DE 69633722 D1 DE69633722 D1 DE 69633722D1
Authority
DE
Germany
Prior art keywords
glutation
analogs
certain
metabolism effect
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69633722T
Other languages
English (en)
Other versions
DE69633722T2 (de
Inventor
M Kauvar
H Lyttle
S Morgan
Richard F Borch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/482,645 external-priority patent/US5767086A/en
Application filed by Telik Inc filed Critical Telik Inc
Publication of DE69633722D1 publication Critical patent/DE69633722D1/de
Application granted granted Critical
Publication of DE69633722T2 publication Critical patent/DE69633722T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69633722T 1995-06-07 1996-06-05 Stoffwechseleffekt von bestimmten glutation analogen Expired - Lifetime DE69633722T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/482,645 US5767086A (en) 1992-04-03 1995-06-07 Bone marrow stimulation by certain glutathione analogs
US482645 1995-06-07
US63651696A 1996-04-19 1996-04-19
US636516 1996-04-19
PCT/US1996/009057 WO1996040205A1 (en) 1995-06-07 1996-06-05 Metabolic effects of certain glutathione analogs

Publications (2)

Publication Number Publication Date
DE69633722D1 true DE69633722D1 (de) 2004-12-02
DE69633722T2 DE69633722T2 (de) 2005-11-03

Family

ID=27047352

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69633722T Expired - Lifetime DE69633722T2 (de) 1995-06-07 1996-06-05 Stoffwechseleffekt von bestimmten glutation analogen

Country Status (10)

Country Link
EP (1) EP0831877B1 (de)
JP (2) JPH11507056A (de)
AT (1) ATE280582T1 (de)
AU (1) AU715524B2 (de)
CA (1) CA2221568C (de)
DE (1) DE69633722T2 (de)
DK (1) DK0831877T3 (de)
ES (1) ES2231814T3 (de)
PT (1) PT831877E (de)
WO (1) WO1996040205A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2089179C1 (ru) * 1995-12-14 1997-09-10 Закрытое акционерное общество "ВАМ" Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования
US6251857B1 (en) 1995-12-14 2001-06-26 Novelos Therapeutics, Inc. Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
KR20010042752A (ko) 1998-04-16 2001-05-25 야스이 쇼사꾸 글루타티온 유도체 및 이의 투여 형태
US20070142267A1 (en) 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
RU2144374C1 (ru) 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток
JP2002535359A (ja) * 1999-01-27 2002-10-22 テリック，インコーポレイテッド グルタチオン類縁体を含有する治療用組成物
US7029695B2 (en) 2001-07-10 2006-04-18 Telik, Inc. Therapeutic compositions containing glutathione analogs
TWI323662B (en) * 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
TW200538149A (en) 2004-05-20 2005-12-01 Telik Inc Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound
SI1833978T1 (sl) 2005-01-06 2009-04-30 Telik Inc Tripeptidni in tetrapeptidni tioetri
US20120251496A1 (en) * 2011-03-31 2012-10-04 Telik, Inc. Ezatiostat for treating multiple myeloma
WO2012176282A1 (ja) 2011-06-21 2012-12-27 日東電工株式会社 アポトーシス誘導剤
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
CN106573062B (zh) 2014-06-17 2020-08-25 日东电工株式会社 细胞凋亡诱导剂
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
EP3880212B1 (de) 2018-11-16 2024-01-17 Nitto Denko Corporation Rna-interferenzabgabeformulierung und verfahren für bösartige tumore
JPWO2020230701A1 (de) 2019-05-14 2020-11-19

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE469132B (sv) * 1989-06-16 1993-05-17 Kabigen Ab Polypeptider och farmaceutisk komposition innehaallande denna
ATE157257T1 (de) * 1990-03-02 1997-09-15 Autoimmune Inc Verstärkung der unterdrückungsregulation von autoimmunkrankheiten durch orale oder enterale verabreichung von autoantigenen
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds
JP3253127B2 (ja) * 1991-06-07 2002-02-04 帝國製薬株式会社 生理活性ポリペプチド含有製剤

Also Published As

Publication number Publication date
ATE280582T1 (de) 2004-11-15
AU6048196A (en) 1996-12-30
EP0831877A1 (de) 1998-04-01
CA2221568C (en) 2010-05-04
DK0831877T3 (da) 2005-02-14
CA2221568A1 (en) 1996-12-19
DE69633722T2 (de) 2005-11-03
JP4520443B2 (ja) 2010-08-04
PT831877E (pt) 2005-03-31
WO1996040205A1 (en) 1996-12-19
EP0831877B1 (de) 2004-10-27
JPH11507056A (ja) 1999-06-22
JP2006348048A (ja) 2006-12-28
ES2231814T3 (es) 2005-05-16
AU715524B2 (en) 2000-02-03

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