PE20121480A1 - Aminopirimidinas como inhibidores de syk - Google Patents

Aminopirimidinas como inhibidores de syk

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Publication number
PE20121480A1
PE20121480A1 PE2012000838A PE2012000838A PE20121480A1 PE 20121480 A1 PE20121480 A1 PE 20121480A1 PE 2012000838 A PE2012000838 A PE 2012000838A PE 2012000838 A PE2012000838 A PE 2012000838A PE 20121480 A1 PE20121480 A1 PE 20121480A1
Authority
PE
Peru
Prior art keywords
pyrimidin
cycloalkyl
hydroxy
phenyl
alkyl
Prior art date
Application number
PE2012000838A
Other languages
English (en)
Inventor
Michael D Altman
Brian M Andresen
Kenneth L Arrington
Konrad Childers Kaleen
Francesco Maria Emilia Di
Anthony Donofrio
John Michael Ellis
Christian Fischer
David Joseph Guerin
Andrew M Haidle
Solomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Michelle R Machacek
Brendan M O'boyle
Ryan D Otte
Alessia Petrocchi
Michael H Reutershan
Eric Romeo
Tony Siu
Brandon M Taoka
B Wesley Trotter
Hua Zhou
Janson Burch
Bernard Cote
Kristina Dupont-Gaudet
Jean-Francois Fournier
Jacques Ives Gauthier
Daniel Guay
Joel S Robichaud
Original Assignee
Merck Sharp & Dohme
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121480(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Merck Canada Inc filed Critical Merck Sharp & Dohme
Publication of PE20121480A1 publication Critical patent/PE20121480A1/es

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AMINOPIRIMIDINAS DE FORMULA (I) DONDE p ES DE 0 A 4; q ES DE 0 A 2; Cy ES CICLOALQUILO(C4-C7), OXETANILO, PIRROLIDINILO, PIPERIDINILO, ENTRE OTROS; R1 ES H, ALQUILO(C1-C4), HALOALQUILO(C1-C4), CICLOALQUILO(C3-C6), ENTRE OTROS; R4 ES H, ALQUILO(C1-C4) O CICLOALQUILO(C3-C4); Ry(a) ES AMINOMETILO, OH, OCH3, F, ENTRE OTROS; Rz(a) ES FLUOROALQUILO(C1-C3), HALOGENO, CN, ALQUILO(C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (1R,4S)-4-[5-(3-CICLOPROPIL-5-{[4-(TRIFLUOROMETIL)PIRIMIDIN-2-IL]AMINO}FENIL)-1,3-TIAZOL-2-IL]-4-HIDROXI-2,2-DIMETILCICLOHEXANOCARBOXILICO; ACIDO (1S,4R)-4-HIDROXI-2,2-DIMETIL-4-{5-[3-METIL-5-(4-METIL-PIRIMIDIN-2-ILAMINO)-FENIL]-TIAZOL-2-IL}-CICLOHEXANOCARBOXILICO; 5-HIDROXI-5-[5-(3-METIL-5-{[4-(TRIFLUOROMETIL)PIRIMIDIN-2-IL]AMINO}FENIL)-1,3-TIAZOL-2-IL]AZEPAN-2-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA DEL BAZO (SYK) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, COLITIS ULCERATIVA, DERMATITIS, PSORIASIS
PE2012000838A 2009-12-17 2010-12-15 Aminopirimidinas como inhibidores de syk PE20121480A1 (es)

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CN102858767B (zh) * 2009-12-17 2015-08-19 默沙东公司 作为syk抑制剂的氨基嘧啶
US8735417B2 (en) 2009-12-17 2014-05-27 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
MX2012007402A (es) 2009-12-23 2012-08-23 Takeda Pharmaceutical Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk).
US8962665B2 (en) 2010-01-12 2015-02-24 Ab Science Thiazole and oxazole kinase inhibitors
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