MX2012007154A - Aminopirimidinas como inhibidores de syk. - Google Patents

Aminopirimidinas como inhibidores de syk.

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Publication number
MX2012007154A
MX2012007154A MX2012007154A MX2012007154A MX2012007154A MX 2012007154 A MX2012007154 A MX 2012007154A MX 2012007154 A MX2012007154 A MX 2012007154A MX 2012007154 A MX2012007154 A MX 2012007154A MX 2012007154 A MX2012007154 A MX 2012007154A
Authority
MX
Mexico
Prior art keywords
aminopyrimidines
syk inhibitors
copd
asthma
enzyme
Prior art date
Application number
MX2012007154A
Other languages
English (en)
Inventor
Christian Fischer
Jacques Yves Gauthier
Michelle R Machacek
Ryan D Otte
Bernard Cote
Alan B Northrup
Francesco Maria Emilia Di
Alessia Petrocchi
B Wesley Trotter
Jason Burch
Michael D Altman
Brian M Andresen
Kenneth L Arrington
Kaleen Konrad Childers
Anthony Donofrio
John Michael Ellis
David Joseph Guerin
Andrew M Haidle
Solomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Brendan M O'boyle
Michael H Reutershan
Eric Romeo
Tony Siu
Brandon M Taoka
Hua Zhou
Kristina Dupont-Gaudet
Daniel Guay
Joel S Robichaud
Jonathan Grimm
Matthew L Maddess
Adam J Schell
Kerrie B Spencer
Hyun Chong Woo
Sathesh Bhat
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012007154(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2012007154A publication Critical patent/MX2012007154A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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Abstract

La presente invención proporciona nuevas pirimidin aminas de fórmula (I) que son potentes inhibidores de la tirosina cinasa del bazo, y son útiles en el tratamiento y prevención de enfermedades mediadas por dicha enzima, tales como asma, COPD y artritis reumatoide.
MX2012007154A 2009-12-17 2010-12-15 Aminopirimidinas como inhibidores de syk. MX2012007154A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28726709P 2009-12-17 2009-12-17
PCT/US2010/060454 WO2011075515A1 (en) 2009-12-17 2010-12-15 Aminopyrimidines as syk inhibitors

Publications (1)

Publication Number Publication Date
MX2012007154A true MX2012007154A (es) 2012-08-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007154A MX2012007154A (es) 2009-12-17 2010-12-15 Aminopirimidinas como inhibidores de syk.

Country Status (27)

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US (3) US8551984B2 (es)
EP (1) EP2513098B1 (es)
JP (2) JP5242857B2 (es)
KR (1) KR101445012B1 (es)
CN (1) CN102858767B (es)
AR (1) AR080672A1 (es)
AU (1) AU2010331927B2 (es)
BR (1) BR112012014703B1 (es)
CA (1) CA2782889C (es)
CL (1) CL2012001627A1 (es)
CO (1) CO6551728A2 (es)
CR (1) CR20120331A (es)
DO (1) DOP2012000166A (es)
EA (1) EA022790B1 (es)
EC (1) ECSP12011982A (es)
ES (1) ES2609040T3 (es)
GE (1) GEP20146125B (es)
GT (1) GT201200202A (es)
MA (1) MA33926B1 (es)
MX (1) MX2012007154A (es)
NI (1) NI201200108A (es)
NZ (1) NZ600673A (es)
PE (1) PE20121480A1 (es)
SG (1) SG181803A1 (es)
TN (1) TN2012000288A1 (es)
TW (1) TW201132637A (es)
WO (2) WO2011075517A1 (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735417B2 (en) 2009-12-17 2014-05-27 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
WO2011075517A1 (en) * 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
PT2516434E (pt) 2009-12-23 2015-10-05 Takeda Pharmaceutical Pirrolidinonas heteroaromáticas fundidas como inibidores de syk
CN102812022B (zh) 2010-01-12 2016-02-03 Ab科学有限公司 噻唑和噁唑激酶抑制剂
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