AR080672A1 - Aminopirimidinas como inhibidores de syk - Google Patents

Aminopirimidinas como inhibidores de syk

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Publication number
AR080672A1
AR080672A1 ARP100104724A ARP100104724A AR080672A1 AR 080672 A1 AR080672 A1 AR 080672A1 AR P100104724 A ARP100104724 A AR P100104724A AR P100104724 A ARP100104724 A AR P100104724A AR 080672 A1 AR080672 A1 AR 080672A1
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Argentina
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alkyl
optionally substituted
independently selected
groups independently
co2ra
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Merck Frosst Canada Ltd
Merck Sharp & Dohme
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Application filed by Merck Frosst Canada Ltd, Merck Sharp & Dohme filed Critical Merck Frosst Canada Ltd
Publication of AR080672A1 publication Critical patent/AR080672A1/es

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Abstract

La presente proporciona pirimidina aminas de formula (1) que son potentes inhibidores de la tirosina quinasa del bazo, y son utiles en el tratamiento y prevencion de enfermedades mediadas por dicha enzima, tales como asma, COPD y artritis reumatoide. Composiciones farmacéuticas. Reivindicacion 1: Un compuesto de formula (1) o una sal farmacéuticamente aceptable del mismo, en la que: p es de 0 a 4; q es 0, 1 o 2; Cy se selecciona entre cicloalquilo C4-7, oxetanilo, pirrolidinilo, piperidinilo y azepanilo; R1 se selecciona entre H, alquilo C1-4, haloalquilo C1-4, cicloalquilo C3-6 y O-alquilo C1-4; R4 se selecciona entre H, alquilo C1-4 y cicloalquilo C3-4; Ry(a) es aminometilo, OH, OCH3, OCH2CH2OH, F, CN, CO2Ra(a), CONRb(a)Rc(a), NRa(a)Ra(a), NHC(O)alquilo C1-3 (opcionalmente sustituido con OH), NHC(O)NH2, NHSO2NH2, NHSO2-alquilo C1-3, o NHSO2-haloalquilo C1-3; Rz(a) se selecciona entre (A) alquilo C1-4 opcionalmente sustituido con uno a tres grupos seleccionados independientemente entre OH, NH2, CN, CO2Ra(a) y CONH2, (B) fluoroalquilo C1-3, (C) halogeno, (D) CN, (E) CO-alquilo C1-4 (opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre ORa(a), CN, CO2Ra(a), CONRa(a)Ra(a) y NRa(a)Ra(a)), (F) CO-fenilo (opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre etinilo, CO2Ra(a), CN, F y OH), (G) CO-cicloalquilo C3-6 (opcionalmente sustituido con OH o CO2Ra(a)), (H) alquil C0-3-CO2Ra(a), (I) -C(O)NRb(a)Rc(a), (J) -ORa(a), (K) -OC(O)Ra(a), (L) -NRb(a)Rc(a), (M) -NHC(O)alquilo C1-4 (opcionalmente sustituido con uno a tres OH o un CONRa(a)Ra(a)), (N) -NHSO2-alquilo C1-3, (O) -NHSO2NH2, (P) oxo, (Q) 1,3,4-oxadiazol-2(3H)-ona, (R) 1,2,4-oxadiazol-5(4H)-ona, (S) SO2NH2, (T) SO2-alquilo C1-3, (U) SO2-haloalquilo C1-3, y (V) SO2Ph; Ra(a) H o alquilo C1-4; Rb(a) y Rc(a) se seleccionan independientemente entre (A) H, (B) cicloalquilo C3-6 opcionalmente sustituido con OH, (C) heteroarilo seleccionado entre imidazolilo, piridilo e indolilo, (D) tetrahidrofuranoilo, (E) bencilo, (F) fenilo opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre (CH2)0-2OH y F, (G1) alquilo C1-4 y (G2) haloalquilo C1-4, en el que cada uno de (G1) y (G2) está opcionalmente sustituido con uno a tres grupos seleccionados independientemente entre (i) OH, (ii) cicloalquilo C3-6 opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre alquilo C1-4, CONH2, CO2H y CH2OH, (iii) CONH2, (iv) SO2NH2, (v) SO2-alquilo C1-4, (vi) heterociclilo monocíclico de 4 a 7 miembros opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre oxo, (CH2)0-2OH y alquilo C1-4, (vii) un heteroarilo de 5 o 6 miembros opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre carboxi, (CH2)0-2OH y alquilo C1-4, (viii) CN, (ix) O-alquilo C1-4, (x) CO2H, (xi) NRa(a)-alquilo C1-4C(O), (xii) fenilo opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre (CH2)0-2OH, SO2NH2, CF3, F y Cl, (xiii) 1-pirrolidinilo opcionalmente sustituido con oxo, (xiv) 1-imidazolidinilo opcionalmente sustituido con oxo, (xv) 1-piperidinilo opcionalmente sustituido con oxo, y (xvi) 4-morfolinilo; o Rb(a) Rc(a) junto con el átomo de nitrogeno al que están unidos forman un heterociclo de 6 o 7 miembros que tiene de 0 a 1 heteroátomo adicional seleccionado entre N, O y S, donde dicho heterociclo está opcionalmente sustituido con uno o dos grupos seleccionados independientemente entre oxo, CN, (CH2)0-2OH, acetilo, bencilo, SO2-alquilo C1-4, CONH2, metoximetilo, carboximetilo, CO2Ra(a) y alquilo C1-4.
ARP100104724A 2009-12-17 2010-12-17 Aminopirimidinas como inhibidores de syk AR080672A1 (es)

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Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102858767B (zh) * 2009-12-17 2015-08-19 默沙东公司 作为syk抑制剂的氨基嘧啶
EP2512246B1 (en) 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
UA107100C2 (xx) 2009-12-23 2014-11-25 Конденсовані гетероароматичні піролідинони як інгібітори syk
CN102812022B (zh) 2010-01-12 2016-02-03 Ab科学有限公司 噻唑和噁唑激酶抑制剂
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
JP5934782B2 (ja) * 2011-05-04 2016-06-15 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． アミノ−ピリジン含有脾臓チロシンキナーゼ（Ｓｙｋ）阻害薬
JP2014513687A (ja) 2011-05-10 2014-06-05 メルク・シャープ・アンド・ドーム・コーポレーション Ｓｙｋ阻害薬としてのピリジルアミノピリジン
US9145391B2 (en) 2011-05-10 2015-09-29 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as Syk inhibitors
AU2012253885A1 (en) * 2011-05-10 2013-10-31 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
JP2014159375A (ja) * 2011-06-15 2014-09-04 Takeda Chem Ind Ltd アゼパン化合物
EP2723739B1 (en) 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
CN104125957B (zh) * 2011-12-21 2016-05-25 拜耳知识产权有限责任公司 取代的苄基吡唑
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
UA117347C2 (uk) 2012-06-13 2018-07-25 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
EP2863914B1 (en) 2012-06-20 2018-10-03 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
WO2013192128A1 (en) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
WO2013192088A1 (en) * 2012-06-22 2013-12-27 Merck Sharp & Dohme Corp. SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2863916B1 (en) * 2012-06-22 2018-07-18 Merck Sharp & Dohme Corp. Substituted pyridine spleen tyrosine kinase (syk) inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
WO2014031438A2 (en) * 2012-08-20 2014-02-27 Merck Sharp & Dohme Corp. SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2900665B1 (en) 2012-09-28 2018-01-03 Merck Sharp & Dohme Corp. Triazolyl derivatives as syk inhibitors
SI2914296T2 (sl) 2012-11-01 2022-01-31 Infinity Pharmaceuticals, Inc. Zdravljenje raznih vrst raka z uporabo modulatorjev izooblik PI3-kinaze
WO2014074421A1 (en) * 2012-11-07 2014-05-15 Merck Sharp & Dohme Corp. Prodrug bipyridylaminopyridines as syk inhibitors
EP2916836A4 (en) * 2012-11-07 2016-08-03 Merck Sharp & Dohme AMINOPYRIDE-CONTAINING MILK TYROSINE KINASE (SYK) INHIBITOR
US9624210B2 (en) 2012-12-12 2017-04-18 Merck Sharp & Dohme Corp. Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9598405B2 (en) 2012-12-21 2017-03-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
WO2014151386A1 (en) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
CN105263931B (zh) 2013-04-19 2019-01-25 因赛特公司 作为fgfr抑制剂的双环杂环
EP2988749B1 (en) * 2013-04-26 2019-08-14 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
US9745295B2 (en) 2013-04-26 2017-08-29 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
SG11201509842SA (en) 2013-05-30 2015-12-30 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015095444A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015094997A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
EP3083559B1 (en) * 2013-12-20 2021-03-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9775839B2 (en) 2014-03-13 2017-10-03 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
UA121669C2 (uk) 2015-02-20 2020-07-10 Інсайт Корпорейшн Біциклічні гетероцикли як інгібітори fgfr
CA3232651A1 (en) 2015-04-02 2016-10-06 Intervet International B.V. Antibodies to canine interleukin-4 receptor alpha
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP7054681B2 (ja) 2016-06-24 2022-04-14 インフィニティー ファーマシューティカルズ， インコーポレイテッド 組合せ療法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN107573263B (zh) * 2017-08-14 2020-04-07 大连理工大学 一种ω-取代缩二脲类化合物的合成方法
IL293332B2 (en) 2017-09-11 2024-02-01 Cyteir Therapeutics Inc RAD51 inhibitors
WO2019076817A1 (en) 2017-10-19 2019-04-25 Bayer Animal Health Gmbh USE OF FUSED HETEROAROMATIC PYRROLIDONES FOR THE TREATMENT AND PREVENTION OF DISEASES IN ANIMALS
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
SG11202010636VA (en) 2018-05-04 2020-11-27 Incyte Corp Solid forms of an fgfr inhibitor and processes for preparing the same
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN114173781A (zh) 2019-03-25 2022-03-11 赛泰尔治疗公司 Rad51和parp抑制剂的组合
EP3966206B1 (en) 2019-05-10 2023-08-09 Deciphera Pharmaceuticals, LLC Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
WO2020257180A1 (en) 2019-06-17 2020-12-24 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
PE20221085A1 (es) 2019-10-14 2022-07-05 Incyte Corp Heterociclos biciclicos como inhibidores de fgfr
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN114746411A (zh) 2019-11-29 2022-07-12 印度鲁宾有限公司 取代的三环化合物
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN115151539A (zh) 2019-12-04 2022-10-04 因赛特公司 Fgfr抑制剂的衍生物
WO2021123094A1 (en) 2019-12-20 2021-06-24 Intervet International B.V. Bispecific caninized antibodies and bispecific binding partners for treating atopic dermatitis
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4229083A1 (en) 2020-10-15 2023-08-23 Intervet International B.V. Caninized antibodies to canine interleukin-31 receptor alpha
BR112023019388A2 (pt) 2021-03-23 2023-11-07 Halia Therapeutics Inc Derivados de pirimidina úteis como inibidores de quinase lrrk2
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2023021170A2 (en) 2021-08-20 2023-02-23 Intervet International B.V. Fusion proteins for treating atopic dermatitis
CN114105958B (zh) * 2021-12-03 2022-11-22 郑州大学第一附属医院 一组含羟肟酸的2-苯氨基嘧啶类衍生物及其应用
WO2023111148A1 (en) 2021-12-16 2023-06-22 Intervet International B.V. Caninized antibodies to canine interleukin-31 receptor alpha 1

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019086A1 (de) 1995-11-17 1997-05-29 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Epothilonderivate, herstellung und verwendung
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
AU2002251266A1 (en) 2001-04-10 2002-10-28 Merck Sharp And Dohme Limited Inhibitors of akt activity
US6958334B2 (en) 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
CA2442270C (en) 2001-04-10 2009-09-08 Merck & Co., Inc. Inhibitors of akt activity
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
DE60214703T2 (de) 2001-06-01 2007-09-13 Vertex Pharmaceuticals Inc., Cambridge Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
US7087614B2 (en) 2001-06-19 2006-08-08 Bristol-Myers Squibb Co. Pyrimidine inhibitors of phosphodiesterase (PDE) 7
GB0123951D0 (en) 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
JP4394960B2 (ja) 2002-04-08 2010-01-06 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性阻害薬
AU2003230802B2 (en) 2002-04-08 2007-08-09 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2003226271B2 (en) 2002-04-08 2007-10-18 Merck Sharp & Dohme Corp. Fused quinoxaline derivatives as inhibitors of Akt activity
WO2003086279A2 (en) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibitors of akt activity
WO2004005283A1 (en) 2002-07-09 2004-01-15 Vertex Pharmaceuticals Incorporated Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities
JP2006524688A (ja) 2003-03-25 2006-11-02 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチアゾール
CA2523126A1 (en) 2003-03-25 2004-10-14 Vertex Pharmaceuticals Incorporated Thiazoles useful as inhibitors of protein kinases
AU2004287261B8 (en) 2003-11-03 2011-01-27 Glaxo Group Limited A fluid dispensing device
US7345043B2 (en) 2004-04-01 2008-03-18 Miikana Therapeutics Inhibitors of histone deacetylase
ES2337496T3 (es) 2005-01-19 2010-04-26 Rigel Pharmaceuticals, Inc. Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos.
AU2006219231B2 (en) * 2005-02-28 2010-01-14 Japan Tobacco Inc. Novel aminopyridine compound with Syk inhibitory activity
ZA200707227B (en) * 2005-02-28 2009-08-26 Japan Tobacco Inc Novel aminopyridine compound with syk inhibitory activity
WO2006129100A1 (en) 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
GB0520838D0 (en) * 2005-10-13 2005-11-23 Glaxo Group Ltd Novel compounds
JP2009536617A (ja) 2006-04-11 2009-10-15 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼの阻害剤として有用なチアゾール、イミダゾール、およびピラゾール
WO2008024634A1 (en) * 2006-08-25 2008-02-28 Smithkline Beecham Corporation Pyrimdine compounds useful as kinase inhibitors
MX2009006081A (es) 2006-12-08 2009-06-17 Irmc Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
TW200840581A (en) 2007-02-28 2008-10-16 Astrazeneca Ab Novel pyrimidine derivatives
US8268850B2 (en) 2007-05-04 2012-09-18 Irm Llc Pyrimidine derivatives and compositions as C-kit and PDGFR kinase inhibitors
WO2009012421A1 (en) 2007-07-17 2009-01-22 Rigel Pharmaceuticals, Inc. Cyclic amine substituted pyrimidinediamines as pkc inhibitors
PT2200436E (pt) 2007-09-04 2015-04-29 Scripps Research Inst Pirimidinilaminas substituídas como inibidoras da proteína quinase
EP2265607B1 (en) 2008-02-15 2016-12-14 Rigel Pharmaceuticals, Inc. Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases
US20100056524A1 (en) * 2008-04-02 2010-03-04 Mciver Edward Giles Compound
EA024109B1 (ru) * 2008-04-16 2016-08-31 Портола Фармасьютиклз, Инк. Ингибиторы протеинкиназ
CN102858767B (zh) 2009-12-17 2015-08-19 默沙东公司 作为syk抑制剂的氨基嘧啶
CN102812022B (zh) * 2010-01-12 2016-02-03 Ab科学有限公司 噻唑和噁唑激酶抑制剂
DE102010000842A1 (de) * 2010-01-13 2011-07-14 Robert Bosch GmbH, 70469 Batterie, Batteriesystem und Verfahren zur Verbindung einer Mehrzahl von Batterien

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