CO6551728A2 - Amino pirimidinas como inhibidores del syk - Google Patents

Amino pirimidinas como inhibidores del syk

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Publication number
CO6551728A2
CO6551728A2 CO12101568A CO12101568A CO6551728A2 CO 6551728 A2 CO6551728 A2 CO 6551728A2 CO 12101568 A CO12101568 A CO 12101568A CO 12101568 A CO12101568 A CO 12101568A CO 6551728 A2 CO6551728 A2 CO 6551728A2
Authority
CO
Colombia
Prior art keywords
amino
pyrimidins
syk inhibitors
enzyme
copd
Prior art date
Application number
CO12101568A
Other languages
English (en)
Inventor
Michael D Altman
Brian M Andresen
Kenneth L Arrington
Kaleen Konrand Childers
Francesco Maria Emilia Di
Anthony Donofrio
John Michael Ellis
Christian Fischer
David Joseph Guerin
Andrew Miguel Haidle
Solomon Kattar
Sandra Lee Knowles
Chaomin Li
Jongwon Lim
Michelle R Machacek
Alan B Northrup
Boyle Brendan M O
Ryan Otte
Alessia Petrocchi
Michael H Reutershan
Eric Romeo
Tony Siu
Brandon Taoka
Wesley B Trotter
Hua Zhou
Jason Burch
Bernard Cote
Kristina Dupont-Gaudet
Jean Francois Fournier
Jacques Yves Gauthier
Daniel Guay
Joel S Robichaud
Original Assignee
Merck Sharp Y Dohme
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43502894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6551728(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp Y Dohme, Merck Canada Inc filed Critical Merck Sharp Y Dohme
Publication of CO6551728A2 publication Critical patent/CO6551728A2/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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Abstract

La presente invención reclama compuestos amino pirimidínicos de la fórmula (I):Que actúan corno potentes inhibidores de la enzima tirosin-quinasa del bazo y que son útiles en el tratamiento y/o prevención de enfermedades mediadas por dicha enzima, tales corno, asma. EPOC y artritis reumatoide.
CO12101568A 2009-12-17 2012-06-15 Amino pirimidinas como inhibidores del syk CO6551728A2 (es)

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US28726709P 2009-12-17 2009-12-17

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CO6551728A2 true CO6551728A2 (es) 2012-10-31

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US (3) US8551984B2 (es)
EP (1) EP2513098B1 (es)
JP (2) JP5242857B2 (es)
KR (1) KR101445012B1 (es)
CN (1) CN102858767B (es)
AR (1) AR080672A1 (es)
AU (1) AU2010331927B2 (es)
BR (1) BR112012014703B1 (es)
CA (1) CA2782889C (es)
CL (1) CL2012001627A1 (es)
CO (1) CO6551728A2 (es)
CR (1) CR20120331A (es)
DO (1) DOP2012000166A (es)
EA (1) EA022790B1 (es)
EC (1) ECSP12011982A (es)
ES (1) ES2609040T3 (es)
GE (1) GEP20146125B (es)
GT (1) GT201200202A (es)
MA (1) MA33926B1 (es)
MX (1) MX2012007154A (es)
NI (1) NI201200108A (es)
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Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011075515A1 (en) * 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
WO2011075560A1 (en) 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
EA021568B1 (ru) 2009-12-23 2015-07-30 Такеда Фармасьютикал Компани Лимитед Конденсированные гетероароматические пирролидиноны как ингибиторы syk
NZ601143A (en) 2010-01-12 2014-10-31 Ab Science Thiazole and oxazole kinase inhibitors
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
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