AR086318A1 - Piridil aminopiridinas como inhibidores de syk - Google Patents

Piridil aminopiridinas como inhibidores de syk

Info

Publication number
AR086318A1
AR086318A1 ARP120101625A ARP120101625A AR086318A1 AR 086318 A1 AR086318 A1 AR 086318A1 AR P120101625 A ARP120101625 A AR P120101625A AR P120101625 A ARP120101625 A AR P120101625A AR 086318 A1 AR086318 A1 AR 086318A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
cycloalkyl
independently selected
haloalkyl
Prior art date
Application number
ARP120101625A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR086318A1 publication Critical patent/AR086318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Son fuertes inhibidores de la tirosina quinasa de bazo y son útiles en el tratamiento y prevención de enfermedades tales como asma, EPOC y artritis reumatoide y cáncer, mediadas por dicha enzima. Composición farmacéutica.Reivindicación 1: Un compuesto que tiene la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en la que A es un carbociclo, o el resto A-(R7)n(R8) representa un compuesto de formula (2), (3) ó (4); n es 0, 1, 2 ó 3; p y q se seleccionan independientemente entre 1, 2 y 3; R1 es alquilo C1-4, fluoroalquilo C1-4, cicloalquilo C3-6 o alcoxi C1-4; R2 es H o halógeno; R3 es H, halógeno, alquilo C1-4, haloalquilo C1-4, cicloalquilo C3-6 o hidroxialquilo C1-4; R4 es H o halógeno; R5 es OH, alcoxi C1-4, halógeno o NH2; o N(H)(alquilo C1-4); R6 es H, alquilo C1-4, haloalquilo C1-4, cicloalquilo C3-6 o hidroxialquilo C1-4; o R7 se selecciona entre OH y alquilo C1-4; R8 se selecciona entre (CRaRb)nCO2Rc, CONRdRe, tetrazolilo, OH, CH2OH, oxo, CN, NHCO2Rf y NHSO2Rf; con la condición de que R8 y -C(R5)(R6)- no estén unidos al mismo átomo de carbono del anillo; cada uno de Ra y Rb se selecciona independientemente entre H y metilo; Rc es H o alquilo C1-4, Rd y Re se seleccionan cada uno independientemente entre H y alquilo C1-4; y Rf es alquilo C1-4 o bencilo.
ARP120101625A 2011-05-10 2012-05-09 Piridil aminopiridinas como inhibidores de syk AR086318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161484431P 2011-05-10 2011-05-10

Publications (1)

Publication Number Publication Date
AR086318A1 true AR086318A1 (es) 2013-12-04

Family

ID=47139532

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101625A AR086318A1 (es) 2011-05-10 2012-05-09 Piridil aminopiridinas como inhibidores de syk

Country Status (8)

Country Link
US (1) US9120785B2 (es)
EP (1) EP2707357B1 (es)
JP (1) JP2014513687A (es)
AR (1) AR086318A1 (es)
AU (1) AU2012253886A1 (es)
CA (1) CA2834062A1 (es)
TW (1) TW201249839A (es)
WO (1) WO2012154520A1 (es)

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KR20130130729A (ko) * 2010-10-28 2013-12-02 니뽄 신야쿠 가부시키가이샤 피리딘 유도체 및 의약
CN103619170B (zh) 2011-05-04 2016-07-06 默沙东公司 含有氨基-吡啶的脾酪氨酸激酶(syk)抑制剂
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JP6267193B2 (ja) * 2012-05-22 2018-01-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 置換ジピリジルアミン類及びそれらの使用
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US9783531B2 (en) 2013-12-20 2017-10-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9822107B2 (en) 2013-12-20 2017-11-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015095444A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9775839B2 (en) 2014-03-13 2017-10-03 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
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Also Published As

Publication number Publication date
US20140100250A1 (en) 2014-04-10
US9120785B2 (en) 2015-09-01
EP2707357A1 (en) 2014-03-19
EP2707357B1 (en) 2017-01-18
JP2014513687A (ja) 2014-06-05
WO2012154520A1 (en) 2012-11-15
EP2707357A4 (en) 2014-12-03
CA2834062A1 (en) 2012-11-15
TW201249839A (en) 2012-12-16
AU2012253886A1 (en) 2013-10-31

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