PE20091377A1 - Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado - Google Patents

Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado

Info

Publication number
PE20091377A1
PE20091377A1 PE2009000009A PE2009000009A PE20091377A1 PE 20091377 A1 PE20091377 A1 PE 20091377A1 PE 2009000009 A PE2009000009 A PE 2009000009A PE 2009000009 A PE2009000009 A PE 2009000009A PE 20091377 A1 PE20091377 A1 PE 20091377A1
Authority
PE
Peru
Prior art keywords
glu
asp
delayed time
insulin derivatives
action profile
Prior art date
Application number
PE2009000009A
Other languages
English (en)
Inventor
Paul Habermann
Gerhard Seipke
Roland Kurrle
Muller Gunter Alwin
Mark Sommerfeld
Norbert Tennagels
Georg Tschank
Ulrich Werner
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40568276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091377(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE200810003568 external-priority patent/DE102008003568A1/de
Priority claimed from DE200810025008 external-priority patent/DE102008025008A1/de
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20091377A1 publication Critical patent/PE20091377A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

REFERIDA A UN ANALOGO DE INSULINA DE FORMULA (I), DONDE A0 ES LYS O ARG; A5 ES ASP, GLN O GLU; A15 ES ASP, GLU O GLN; A18 ES ASP, GLU O ASN; B-1 ES ASP, GLU O UN GRUPO AMINO; B0 ES ASP, GLU O UN ENLACE QUIMICO; B1 ES ASP, GLU O PHE; B2 ES ASP, GLU O VAL; B3 ES ASP, GLU O ASN; B4 ES ASP, GLU O GLN; B29 ES LYS O UN ENLACE QUIMICO; B30 ES THR O UN ENLACE QUIMICO; B31 ES ARG, LYS O UN ENLACE QUIMICO; B32 ES ARG-AMIDA, LYS-AMIDA O UN ENLACE QUIMICO. TAMBIEN ESTA REFERIDA A UN ANALOGO DE PREPROINSULINA Y A UNA FORMULACION ACUOSA DEL ANALOGO DE INSULINA
PE2009000009A 2008-01-09 2009-01-07 Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado PE20091377A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200810003568 DE102008003568A1 (de) 2008-01-09 2008-01-09 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE200810025008 DE102008025008A1 (de) 2008-05-24 2008-05-24 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil

Publications (1)

Publication Number Publication Date
PE20091377A1 true PE20091377A1 (es) 2009-09-26

Family

ID=40568276

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000009A PE20091377A1 (es) 2008-01-09 2009-01-07 Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado

Country Status (32)

Country Link
US (1) US9644017B2 (es)
EP (1) EP2229407B1 (es)
JP (1) JP5694779B2 (es)
KR (1) KR20100111682A (es)
CN (1) CN102007143B (es)
AR (1) AR070118A1 (es)
AU (1) AU2009203809B2 (es)
BR (1) BRPI0907371A2 (es)
CA (1) CA2711749A1 (es)
CL (1) CL2009000017A1 (es)
CO (1) CO6311108A2 (es)
DK (1) DK2229407T3 (es)
DO (1) DOP2010000209A (es)
EC (1) ECSP10010333A (es)
ES (1) ES2613152T3 (es)
GT (1) GT201000199A (es)
HK (1) HK1149772A1 (es)
HU (1) HUE030537T2 (es)
IL (1) IL206844A (es)
MA (1) MA31998B1 (es)
MY (1) MY152979A (es)
NI (1) NI201000114A (es)
NZ (1) NZ586590A (es)
PA (1) PA8811601A1 (es)
PE (1) PE20091377A1 (es)
PL (1) PL2229407T3 (es)
RU (1) RU2524423C2 (es)
TN (1) TN2010000298A1 (es)
TW (1) TW200942256A (es)
UY (1) UY31596A1 (es)
WO (1) WO2009087081A2 (es)
ZA (1) ZA201003926B (es)

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CN102007143B (zh) 2015-08-26
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