OA13287A - Therapeutic foam. - Google Patents
Therapeutic foam. Download PDFInfo
- Publication number
- OA13287A OA13287A OA1200600161A OA1200600161A OA13287A OA 13287 A OA13287 A OA 13287A OA 1200600161 A OA1200600161 A OA 1200600161A OA 1200600161 A OA1200600161 A OA 1200600161A OA 13287 A OA13287 A OA 13287A
- Authority
- OA
- OAPI
- Prior art keywords
- foam
- gas
- canister
- liquid
- nitrogen
- Prior art date
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- 239000006260 foam Substances 0.000 title claims abstract description 368
- 230000001225 therapeutic effect Effects 0.000 title abstract description 7
- 239000007789 gas Substances 0.000 claims abstract description 320
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 234
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 232
- 239000007788 liquid Substances 0.000 claims abstract description 143
- 238000000034 method Methods 0.000 claims abstract description 120
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 119
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 110
- 239000001301 oxygen Substances 0.000 claims abstract description 97
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 97
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 96
- 239000000203 mixture Substances 0.000 claims abstract description 81
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 77
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 165
- 239000012071 phase Substances 0.000 claims description 25
- 210000003462 vein Anatomy 0.000 claims description 24
- 238000002347 injection Methods 0.000 claims description 23
- 239000007924 injection Substances 0.000 claims description 23
- 239000007791 liquid phase Substances 0.000 claims description 19
- 239000003229 sclerosing agent Substances 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 238000011010 flushing procedure Methods 0.000 claims description 6
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 claims description 5
- 238000011109 contamination Methods 0.000 claims description 4
- FVEFRICMTUKAML-UHFFFAOYSA-M sodium tetradecyl sulfate Chemical compound [Na+].CCCCC(CC)CCC(CC(C)C)OS([O-])(=O)=O FVEFRICMTUKAML-UHFFFAOYSA-M 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 91
- 206010046996 Varicose vein Diseases 0.000 abstract description 15
- 208000027185 varicose disease Diseases 0.000 abstract description 13
- 239000008152 sclerosing solution Substances 0.000 abstract description 2
- 229960005419 nitrogen Drugs 0.000 description 113
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 95
- 229920001363 Polidocanol Polymers 0.000 description 94
- 229960002226 polidocanol Drugs 0.000 description 94
- 229960004424 carbon dioxide Drugs 0.000 description 74
- 239000003570 air Substances 0.000 description 70
- 239000008280 blood Substances 0.000 description 46
- 210000004369 blood Anatomy 0.000 description 46
- 238000005187 foaming Methods 0.000 description 29
- 239000012535 impurity Substances 0.000 description 29
- 230000000694 effects Effects 0.000 description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- 239000000047 product Substances 0.000 description 25
- 238000012360 testing method Methods 0.000 description 25
- 238000002156 mixing Methods 0.000 description 24
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- 229910001873 dinitrogen Inorganic materials 0.000 description 13
- 239000011521 glass Substances 0.000 description 12
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 238000007632 sclerotherapy Methods 0.000 description 11
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 10
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- 230000000994 depressogenic effect Effects 0.000 description 10
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- 230000008569 process Effects 0.000 description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
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- 239000000126 substance Substances 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 239000004411 aluminium Substances 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 229910001882 dioxygen Inorganic materials 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000001272 nitrous oxide Substances 0.000 description 5
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- -1 70% Chemical compound 0.000 description 4
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- 229920002302 Nylon 6,6 Polymers 0.000 description 3
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- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 240000006909 Tilia x europaea Species 0.000 description 2
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- 238000005260 corrosion Methods 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 230000000881 depressing effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
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- 239000004744 fabric Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 230000036244 malformation Effects 0.000 description 2
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- 230000004048 modification Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical compound CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 201000009371 venous hemangioma Diseases 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical class CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- VPSXHKGJZJCWLV-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(1-ethylpiperidin-4-yl)oxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CCN(CC1)CC VPSXHKGJZJCWLV-UHFFFAOYSA-N 0.000 description 1
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
- 101150091111 ACAN gene Proteins 0.000 description 1
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- 241001644893 Entandrophragma utile Species 0.000 description 1
- KGWDUNBJIMUFAP-KVVVOXFISA-N Ethanolamine Oleate Chemical compound NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O KGWDUNBJIMUFAP-KVVVOXFISA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
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- 239000004698 Polyethylene Substances 0.000 description 1
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- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920003082 Povidone K 90 Polymers 0.000 description 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
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- VNWKTOKETHGBQD-AKLPVKDBSA-N carbane Chemical compound [15CH4] VNWKTOKETHGBQD-AKLPVKDBSA-N 0.000 description 1
- OKTJSMMVPCPJKN-YPZZEJLDSA-N carbon-10 atom Chemical compound [10C] OKTJSMMVPCPJKN-YPZZEJLDSA-N 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 description 1
- GRIXGZQULWMCLU-UHFFFAOYSA-L disodium;7-[[2-carboxylato-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].C12OCC(CSC=3N(N=NN=3)C)=C(C([O-])=O)N2C(=O)C1(OC)NC(=O)C(C([O-])=O)C1=CC=C(O)C=C1 GRIXGZQULWMCLU-UHFFFAOYSA-L 0.000 description 1
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- LGLLXTFYYXSARU-PMACEKPBSA-N ethyl (2s)-2-[[(2s)-2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-methylbutanoate Chemical compound CCOC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(C)=O)CC1=CC=C(N(CCCl)CCCl)C=C1 LGLLXTFYYXSARU-PMACEKPBSA-N 0.000 description 1
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- VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 description 1
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- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
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- 208000010125 myocardial infarction Diseases 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00008—Vein tendon strippers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
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Landscapes
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0326768A GB0326768D0 (en) | 2003-11-17 | 2003-11-17 | Generation of therapeutic microfoam |
| US54286604P | 2004-02-10 | 2004-02-10 | |
| US54286704P | 2004-02-10 | 2004-02-10 | |
| GB0422307A GB0422307D0 (en) | 2004-10-07 | 2004-10-07 | Generation and delivery of therapeutic microfoam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA13287A true OA13287A (en) | 2007-01-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200600161A OA13287A (en) | 2003-11-17 | 2004-11-17 | Therapeutic foam. |
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| EP (4) | EP1701701B2 (OSRAM) |
| JP (4) | JP4988353B2 (OSRAM) |
| KR (4) | KR20060130074A (OSRAM) |
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| SI (3) | SI1701701T1 (OSRAM) |
| WO (4) | WO2005048983A1 (OSRAM) |
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| GB9912356D0 (en) * | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| GB0028692D0 (en) | 2000-11-24 | 2001-01-10 | Btg Int Ltd | Generation of therapeutic microform |
| US8512680B2 (en) * | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| AU2004290957A1 (en) | 2003-11-17 | 2005-06-02 | Btg International Limited | Methods of preparing a foam comprising a sclerosing agent |
| US8048439B2 (en) * | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| ITMI20041056A1 (it) * | 2004-05-26 | 2004-08-26 | Garrido Antonio Luis Cabrera | Uso in campo medico diagnostico e flebo logico di una kiscela di gas sterili e fisiologicamente accettabili |
| WO2006120469A2 (en) * | 2005-05-13 | 2006-11-16 | Btg International Limited | Therapeutic sclerosing foam made preferably xenon |
| GB0509819D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| GB0509824D0 (en) * | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| GB0509845D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Preparation of therapeutic foam |
| ATE509863T1 (de) | 2005-10-21 | 2011-06-15 | Btg Int Ltd | Aerosolventil |
| US20080243068A1 (en) * | 2005-12-29 | 2008-10-02 | Kamal Ramzipoor | Methods and apparatus for treatment of venous insufficiency |
| US20090038701A1 (en) | 2006-01-17 | 2009-02-12 | Baxter International Inc. | Device, system and method for mixing |
| AU2013213741B2 (en) * | 2006-01-17 | 2016-01-28 | Baxter Healthcare Sa | Device, system and method for mixing |
| US20100274279A1 (en) * | 2006-01-17 | 2010-10-28 | Yves Delmotte | Device, System and Method for Mixing |
| US20100101579A1 (en) * | 2006-11-27 | 2010-04-29 | Frank Levy | Portable Medical Gas Delivery System |
| US8876749B2 (en) | 2006-11-27 | 2014-11-04 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US9662435B2 (en) | 2006-01-31 | 2017-05-30 | Frank Levy | System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
| US9486594B2 (en) | 2006-11-27 | 2016-11-08 | Frank Levy | Portable medical gas delivery system |
| US8469924B2 (en) | 2006-04-04 | 2013-06-25 | Covidien Lp | Method and apparatus for generating vascular treatment foam |
| WO2008063222A2 (en) * | 2006-05-11 | 2008-05-29 | Dentsply International Inc. | Aerosol delivery system for dispensing dental compositions |
| ES2289947B1 (es) * | 2006-07-25 | 2009-02-16 | Universidade De Santiago De Compostela | Microespuma esclerosante con co2, dispositivo de preparacion y sus aplicaciones. |
| US9427522B2 (en) | 2006-11-27 | 2016-08-30 | Frank Levy | Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid |
| US10149935B2 (en) | 2006-11-27 | 2018-12-11 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
| US11185671B2 (en) | 2006-11-27 | 2021-11-30 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US12377251B2 (en) | 2006-11-27 | 2025-08-05 | Frank Levy | Apparatus and method for producing an enriched medical suspension of carbon dioxide |
| US11712510B2 (en) | 2006-11-27 | 2023-08-01 | Frank Levy | Delivery system and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid |
| US10155093B2 (en) | 2006-11-27 | 2018-12-18 | Frank Levy | Apparatus and method for producing CO2 enriched medical foam |
| US11833320B2 (en) | 2006-11-27 | 2023-12-05 | Frank Levy | Apparatus and process for producing CO2 enriched medical foam |
| US10350399B2 (en) | 2006-11-27 | 2019-07-16 | Frank Levy | Apparatus and method for producing an enriched medical suspension of carbon dioxide |
| US20190070397A1 (en) * | 2006-11-27 | 2019-03-07 | Frank Levy | Apparatus and method for producing co2 enriched medical foam |
| US10322271B2 (en) | 2006-11-27 | 2019-06-18 | Frank Levy | Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid |
| US20080140002A1 (en) * | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
| JP5069753B2 (ja) * | 2006-12-21 | 2012-11-07 | ビーティージー・インターナショナル・リミテッド | 治療用フォームを生産するための装置および方法 |
| AU2008207828B2 (en) * | 2007-01-25 | 2013-09-19 | Hyperbranch Medical Technology, Inc. | Applicators for multiple component formulations and the like, and methods of use thereof |
| CN104800931A (zh) * | 2007-11-08 | 2015-07-29 | 尼克斯梅德控股公司 | 用于混合和分配彼此分开储存的成分的装置和系统 |
| US8753670B2 (en) | 2008-03-26 | 2014-06-17 | Baxter International Inc. | Fibrin foam and process |
| US8512740B2 (en) | 2008-03-26 | 2013-08-20 | Baxter International Inc. | Fibrin foam and process for making |
| US20110139821A1 (en) * | 2008-09-22 | 2011-06-16 | Medmix Systems Ag | Connector having mixing element for discharge arrangement |
| US8560968B1 (en) * | 2009-03-26 | 2013-10-15 | Vinod Nair | Method and apparatus for evaluating a heart patient |
| US8376989B2 (en) * | 2009-03-30 | 2013-02-19 | Covidien Lp | Compartmented syringe |
| KR20120048581A (ko) | 2009-09-08 | 2012-05-15 | 박스터 헬쓰케어 에스.에이. | 상처 밀봉 제품을 위한 복원 및 도포기 시스템 |
| US20110082340A1 (en) * | 2009-10-07 | 2011-04-07 | Tyco Healthercare Group LP | Foam collar for surgical access devices |
| US8641661B2 (en) | 2010-01-05 | 2014-02-04 | Baxter International Inc. | Mixing system, kit and mixer adapter |
| EP2384703A1 (en) * | 2010-05-05 | 2011-11-09 | Bioadhesives Meditech Solutions, S.L. | Device for dispensing a two-component tissue adhesive or sealant |
| KR20130103489A (ko) * | 2010-08-06 | 2013-09-23 | 호스피라 오스트레일리아 피티와이 리미티드 | 바이알 제조 방법 및 시스템 |
| EP2776091B1 (en) | 2011-11-07 | 2021-03-03 | Battelle Memorial Institute | Processes for delivery of viscous drug therapies |
| US9937317B2 (en) * | 2012-01-30 | 2018-04-10 | Ipsumpro, S.L. | Modified medical syringe with a flow regulator for the administration of local anaesthetic |
| WO2013155009A1 (en) * | 2012-04-09 | 2013-10-17 | Becton, Dickinson And Company | Injection mechanism utilizing a vial |
| EP2656869B1 (en) * | 2012-04-24 | 2020-10-14 | angioclinic AG | Composition for treating venous insufficiency and varicose veins |
| US8968449B2 (en) * | 2012-07-04 | 2015-03-03 | Vki Technologies Inc. | Spout, system, and method for producing a foam |
| US9398913B2 (en) * | 2012-08-24 | 2016-07-26 | St. Jude Medical Puerto Rico Llc | Sealant storage, preparation, and delivery systems and related methods |
| EP2722008B1 (de) * | 2012-10-16 | 2018-01-17 | Erbe Elektromedizin GmbH | Düse zur Zufuhr von biologischem Material, insbesondere Zellen, medizinische Vorrichtung mit einer derartigen Düse, Verwendung einer Düse, Verfahren zum Mischen von Fluiden und Gerät |
| JP6362145B2 (ja) * | 2012-11-30 | 2018-07-25 | ユーエヌエル ホールディングス エルエルシーUNL Holdings LLC | デュアルチャンバ混合シリンジ用複合プランジャ装置 |
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- 2004-11-17 SI SI200431374T patent/SI1701701T1/sl unknown
- 2004-11-17 BR BRPI0416611A patent/BRPI0416611B8/pt not_active IP Right Cessation
- 2004-11-17 OA OA1200600161A patent/OA13287A/en unknown
- 2004-11-17 PT PT04798564T patent/PT1701701E/pt unknown
- 2004-11-17 JP JP2006540586A patent/JP4988353B2/ja not_active Expired - Fee Related
- 2004-11-17 PT PT04798566T patent/PT1694292E/pt unknown
- 2004-11-17 PL PL04798566T patent/PL1694292T5/pl unknown
- 2004-11-17 KR KR1020067012051A patent/KR20060130074A/ko not_active Withdrawn
- 2004-11-17 IN IN7569DEN2014 patent/IN2014DN07569A/en unknown
- 2004-11-17 AU AU2004290963A patent/AU2004290963A1/en not_active Abandoned
- 2004-11-17 EP EP04798564.3A patent/EP1701701B2/en not_active Expired - Lifetime
- 2004-11-17 CA CA002546108A patent/CA2546108A1/en not_active Abandoned
- 2004-11-17 EP EP04798566.8A patent/EP1694292B2/en not_active Expired - Lifetime
- 2004-11-17 DE DE602004024925T patent/DE602004024925D1/de not_active Expired - Lifetime
- 2004-11-17 KR KR1020067012049A patent/KR20060127001A/ko not_active Withdrawn
- 2004-11-17 SI SI200431254A patent/SI1694292T2/sl unknown
- 2004-11-17 EA EA200600985A patent/EA009362B1/ru not_active IP Right Cessation
- 2004-11-17 EP EP04798550.2A patent/EP1791519B1/en not_active Expired - Lifetime
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- 2004-11-17 DE DE602004022190T patent/DE602004022190D1/de not_active Expired - Lifetime
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- 2004-11-17 WO PCT/GB2004/004824 patent/WO2005048983A1/en not_active Ceased
- 2004-11-17 EP EP04798543A patent/EP1684718A1/en not_active Withdrawn
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- 2004-11-17 AU AU2004290959A patent/AU2004290959A1/en not_active Abandoned
- 2004-11-17 SI SI200431254T patent/SI1694292T1/sl unknown
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- 2004-11-17 DK DK04798566.8T patent/DK1694292T4/en active
- 2004-11-17 PL PL04798564T patent/PL1701701T5/pl unknown
- 2004-11-17 JP JP2006540585A patent/JP2007511591A/ja active Pending
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- 2004-11-17 WO PCT/GB2004/004846 patent/WO2005048984A1/en not_active Ceased
- 2004-11-17 PL PL380484A patent/PL223344B1/pl unknown
- 2004-11-17 CN CN2004800339138A patent/CN1960705B/zh not_active Expired - Lifetime
- 2004-11-17 WO PCT/GB2004/004831 patent/WO2005048976A2/en not_active Ceased
- 2004-11-17 CZ CZ20060315A patent/CZ2006315A3/cs unknown
- 2004-11-17 ES ES04798564T patent/ES2339117T5/es not_active Expired - Lifetime
- 2004-11-17 KR KR1020067012047A patent/KR20070005551A/ko not_active Withdrawn
- 2004-11-17 KR KR1020067012055A patent/KR101172081B1/ko not_active Expired - Fee Related
- 2004-11-17 CA CA2546232A patent/CA2546232C/en not_active Expired - Lifetime
-
2006
- 2006-05-16 EC EC2006006574A patent/ECSP066574A/es unknown
- 2006-05-16 IL IL175672A patent/IL175672A/en active IP Right Grant
- 2006-05-30 MA MA29064A patent/MA31041B1/fr unknown
- 2006-06-19 NO NO20062866A patent/NO20062866L/no not_active Application Discontinuation
-
2009
- 2009-10-22 CY CY20091101097T patent/CY1110513T1/el unknown
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2010
- 2010-03-29 CY CY20101100292T patent/CY1110621T1/el unknown
- 2010-04-23 US US12/765,980 patent/US8323677B2/en not_active Expired - Fee Related
-
2012
- 2012-11-02 US US13/667,296 patent/US8734833B2/en not_active Expired - Fee Related
-
2014
- 2014-04-09 US US14/248,715 patent/US20140221501A1/en not_active Abandoned
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2015
- 2015-05-08 US US14/708,096 patent/US10472100B2/en not_active Expired - Lifetime
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