OA07151A - Dérivés de la pyrrolidine . - Google Patents

Dérivés de la pyrrolidine .

Info

Publication number
OA07151A
OA07151A OA57742A OA57742A OA07151A OA 07151 A OA07151 A OA 07151A OA 57742 A OA57742 A OA 57742A OA 57742 A OA57742 A OA 57742A OA 07151 A OA07151 A OA 07151A
Authority
OA
OAPI
Prior art keywords
formula
hydrogen
useful
pyrrolidine derivatives
iii
Prior art date
Application number
OA57742A
Other languages
English (en)
Inventor
Werner Aschwanden
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH4849/81A external-priority patent/CH647234A5/de
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of OA07151A publication Critical patent/OA07151A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
OA57742A 1981-07-24 1982-07-19 Dérivés de la pyrrolidine . OA07151A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4849/81A CH647234A5 (en) 1981-07-24 1981-07-24 Pyrrolidine derivatives
CH276882 1982-05-05

Publications (1)

Publication Number Publication Date
OA07151A true OA07151A (fr) 1984-03-31

Family

ID=25691358

Family Applications (1)

Application Number Title Priority Date Filing Date
OA57742A OA07151A (fr) 1981-07-24 1982-07-19 Dérivés de la pyrrolidine .

Country Status (34)

Country Link
US (3) US4476308A (fr)
EP (1) EP0071216B1 (fr)
AT (2) AT384424B (fr)
AU (1) AU557651B2 (fr)
BG (1) BG38334A3 (fr)
CA (1) CA1176251A (fr)
CS (1) CS226746B2 (fr)
DD (1) DD202540A5 (fr)
DE (2) DE3227649A1 (fr)
DK (1) DK157848C (fr)
EG (1) EG15921A (fr)
ES (1) ES8307743A1 (fr)
FI (1) FI75158C (fr)
FR (1) FR2515179A1 (fr)
GB (2) GB2110207B (fr)
HK (1) HK53788A (fr)
HU (1) HU187777B (fr)
IE (1) IE53428B1 (fr)
IL (1) IL66341A (fr)
IT (1) IT1152287B (fr)
LU (1) LU84294A1 (fr)
MC (1) MC1476A1 (fr)
MT (1) MTP915B (fr)
NL (1) NL8202922A (fr)
NO (1) NO159592C (fr)
NZ (1) NZ201297A (fr)
OA (1) OA07151A (fr)
PH (1) PH19149A (fr)
PT (1) PT75314B (fr)
RO (1) RO84097B (fr)
SE (1) SE8204445L (fr)
SG (1) SG22788G (fr)
SU (1) SU1281172A3 (fr)
ZW (1) ZW14482A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173763B (it) * 1984-03-30 1987-06-24 Proter Spa Derivati dell'acido 3-mercapto-2-oxo-1-pirrolidinacetico,procedimento di preparazione e composizioni farmaceutiche che li contengono
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US4758585A (en) * 1985-08-16 1988-07-19 Warner-Lambert Company Saturated cycloalkyl (B) pyrrol-1 (2H)- acetic acid amides and derivatives thereof
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
CA1322199C (fr) * 1987-07-15 1993-09-14 Masami Eigyo Derives n-(2 oxopyrrolidin-1-yl) acetylpiperazine et medicaments pour la demence senile
JPS6422883A (en) * 1987-07-17 1989-01-25 Sanwa Kagaku Kenkyusho Co 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
WO1989010359A1 (fr) * 1988-04-22 1989-11-02 2 Moskovsky Gosudarstvenny Meditsinsky Institut Im Ethers de carbalkoxymethyl d'acide acetique de lactame-1 et procede pour leur obtention
IT1245870B (it) * 1991-06-05 1994-10-25 Sigma Tau Ind Farmaceuti 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2100641A1 (fr) * 1992-07-23 1994-01-24 Hiromu Matsumura Derives de piperidine et procede pour leur obtention
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
JP2001524071A (ja) * 1996-11-22 2001-11-27 モナ・インダストリーズ・インコーポレーテッド カルボキシル官能基を有するシリコーンモノマー及びオリゴマー
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
ES2637497T3 (es) 2008-10-16 2017-10-13 The Johns Hopkins University Procedimientos y composiciones para la mejora de la función cognitiva
CA2789014C (fr) * 2010-02-09 2019-01-15 Michela Gallagher Procedes et compositions pour ameliorer la fonction cognitive
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3827820A1 (fr) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam pour améliorer la fonction cognitive
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
CN107810002B (zh) 2015-05-22 2021-01-05 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
CA1124247A (fr) * 1979-08-09 1982-05-25 Hoffmann-La Roche Limited Derives de pyrrolidine
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
BE892942A (fr) * 1982-04-23 1982-10-25 Ucb Sa Procede pour prevenir ou attenuer les psychoses iatrogenes causees par les medicaments a activite cytostatique.

Also Published As

Publication number Publication date
US4650878A (en) 1987-03-17
ATA286382A (de) 1987-04-15
DE3227649A1 (de) 1983-02-10
BG38334A3 (en) 1985-11-15
US5034402A (en) 1991-07-23
NO822222L (no) 1983-01-25
FR2515179B1 (fr) 1985-01-18
PH19149A (en) 1986-01-15
NZ201297A (en) 1985-12-13
PT75314B (en) 1985-11-29
PT75314A (en) 1982-08-01
GB2152038B (en) 1986-01-02
FI75158C (fi) 1988-05-09
SU1281172A3 (ru) 1986-12-30
ES514267A0 (es) 1983-08-16
US4476308B1 (fr) 1987-03-10
EG15921A (en) 1986-09-30
EP0071216B1 (fr) 1986-12-30
US4476308A (en) 1984-10-09
GB2110207A (en) 1983-06-15
NO159592B (no) 1988-10-10
IE821768L (en) 1983-01-24
IE53428B1 (en) 1988-11-09
HK53788A (en) 1988-07-22
MTP915B (en) 1985-12-28
IT8222335A1 (it) 1984-01-09
NO159592C (no) 1989-01-18
AU557651B2 (en) 1987-01-08
EP0071216A2 (fr) 1983-02-09
ATE24488T1 (de) 1987-01-15
DK157848B (da) 1990-02-26
AT384424B (de) 1987-11-10
ZW14482A1 (en) 1983-02-09
GB2152038A (en) 1985-07-31
FI75158B (fi) 1988-01-29
SE8204445L (sv) 1983-01-25
IL66341A (en) 1986-12-31
FI822543L (fi) 1983-01-25
DE3274851D1 (en) 1987-02-05
CA1176251A (fr) 1984-10-16
IT8222335A0 (it) 1982-07-09
NL8202922A (nl) 1983-02-16
LU84294A1 (de) 1984-03-22
DD202540A5 (de) 1983-09-21
EP0071216A3 (en) 1983-09-07
GB2110207B (en) 1985-09-04
FR2515179A1 (fr) 1983-04-29
AU8615882A (en) 1983-01-27
HU187777B (en) 1986-02-28
GB8426076D0 (en) 1984-11-21
FI822543A0 (fi) 1982-07-19
MC1476A1 (fr) 1983-06-17
RO84097A (fr) 1984-05-12
SE8204445D0 (sv) 1982-07-23
RO84097B (ro) 1984-06-30
DK317382A (da) 1983-01-25
IT1152287B (it) 1986-12-31
ES8307743A1 (es) 1983-08-16
IL66341A0 (en) 1982-11-30
SG22788G (en) 1988-07-15
DK157848C (da) 1990-07-23
CS226746B2 (en) 1984-04-16

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