RO84097B - Procedeu pentru prepararea unor derivati de pirolidina - Google Patents

Procedeu pentru prepararea unor derivati de pirolidina

Info

Publication number
RO84097B
RO84097B RO108194A RO10819482A RO84097B RO 84097 B RO84097 B RO 84097B RO 108194 A RO108194 A RO 108194A RO 10819482 A RO10819482 A RO 10819482A RO 84097 B RO84097 B RO 84097B
Authority
RO
Romania
Prior art keywords
hydrogen
lower alkyl
formula
general formula
formula iii
Prior art date
Application number
RO108194A
Other languages
English (en)
Other versions
RO84097A (ro
Inventor
Werner Aschwander
Emilio Kyburz
Original Assignee
F.Hoffmann- La Roche And Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH4849/81A external-priority patent/CH647234A5/de
Application filed by F.Hoffmann- La Roche And Co. Aktiengesellschaft filed Critical F.Hoffmann- La Roche And Co. Aktiengesellschaft
Publication of RO84097A publication Critical patent/RO84097A/ro
Publication of RO84097B publication Critical patent/RO84097B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Electronic Switches (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de pirolidina cu formula generala I (vezi formula în pag.1 a descrierii) în care R1 este hidrogen sau alcanoil inferior, R2 este hidrogen sau alchil inferior si R3 este hidrogen, alchil inferior sau un radical cu formula -(CH2)n-NR4R5, n este un numar întreg de la 2 la 4, iar R4 si R5 sînt, independent unul de celalalt, hidrogen sau alchil inferior sau împreuna cu atomul de azot formeaza un radical de pirolidina, piperidina, piperazina sau morfolina care poate fi, eventual, mono sau disubstituit cu alchil inferior, constînd din aceea ca un compus cu formula generala II: H2N-R3 în care R3 are semnificatiile de mai sus, se trateaza cu un acid carboxilic cu formula generala III (vezi formula în pag.1 a descrierii) în care R2 are semnificatiile de mai sus, iar R11 este hidrogen sau alcanoil inferior sau, daca R3 din formula II este hidrogen, R11 reprezinta (3-oxo-4,7,7-trimet 1-2-oxabiciclo [2,2,1]hept-1-il)-carbonil sau cu un derivat reactiv al compusului cu formula III, ales dintre un ester alchilic inferior, o halogenura acida, o imidazolida si o anhidrida, la o temperatura cuprinsa între temperatura camerei si 100 degree C, în prezenta unui solvent ales între apa, clorura de metilen, cloroform, tetrahidrofuran, metanol, dimetilformamida, acetonitril sau un exces din amina cu formula II utilizata în reactie, în prezenta diciclohexil-carbodiimidei singura sau în amestec cu N-hidroxisuccinimida sau 1-(alchil inferior)-2-halogen-piridiniu ca agent de condensare, în cazul în care se foloseste în reactie cu acid carboxilic liber cu formula III, iar în cazul în care se foloseste d
RO108194A 1981-07-24 1982-07-19 Procedeu pentru prepararea unor derivati de pirolidina RO84097B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4849/81A CH647234A5 (en) 1981-07-24 1981-07-24 Pyrrolidine derivatives
CH276882 1982-05-05

Publications (2)

Publication Number Publication Date
RO84097A RO84097A (ro) 1984-05-12
RO84097B true RO84097B (ro) 1984-06-30

Family

ID=25691358

Family Applications (1)

Application Number Title Priority Date Filing Date
RO108194A RO84097B (ro) 1981-07-24 1982-07-19 Procedeu pentru prepararea unor derivati de pirolidina

Country Status (34)

Country Link
US (3) US4476308A (ro)
EP (1) EP0071216B1 (ro)
AT (2) AT384424B (ro)
AU (1) AU557651B2 (ro)
BG (1) BG38334A3 (ro)
CA (1) CA1176251A (ro)
CS (1) CS226746B2 (ro)
DD (1) DD202540A5 (ro)
DE (2) DE3227649A1 (ro)
DK (1) DK157848C (ro)
EG (1) EG15921A (ro)
ES (1) ES514267A0 (ro)
FI (1) FI75158C (ro)
FR (1) FR2515179A1 (ro)
GB (2) GB2110207B (ro)
HK (1) HK53788A (ro)
HU (1) HU187777B (ro)
IE (1) IE53428B1 (ro)
IL (1) IL66341A (ro)
IT (1) IT1152287B (ro)
LU (1) LU84294A1 (ro)
MC (1) MC1476A1 (ro)
MT (1) MTP915B (ro)
NL (1) NL8202922A (ro)
NO (1) NO159592C (ro)
NZ (1) NZ201297A (ro)
OA (1) OA07151A (ro)
PH (1) PH19149A (ro)
PT (1) PT75314B (ro)
RO (1) RO84097B (ro)
SE (1) SE8204445L (ro)
SG (1) SG22788G (ro)
SU (1) SU1281172A3 (ro)
ZW (1) ZW14482A1 (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173763B (it) * 1984-03-30 1987-06-24 Proter Spa Derivati dell'acido 3-mercapto-2-oxo-1-pirrolidinacetico,procedimento di preparazione e composizioni farmaceutiche che li contengono
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US4758585A (en) * 1985-08-16 1988-07-19 Warner-Lambert Company Saturated cycloalkyl (B) pyrrol-1 (2H)- acetic acid amides and derivatives thereof
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
CA1322199C (en) * 1987-07-15 1993-09-14 Masami Eigyo N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia
JPS6422883A (en) * 1987-07-17 1989-01-25 Sanwa Kagaku Kenkyusho Co 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
WO1989010359A1 (en) * 1988-04-22 1989-11-02 2 Moskovsky Gosudarstvenny Meditsinsky Institut Im Carbalkoxymethyl ethers of lactam-1-acetic acid and method of obtaining them
IT1245870B (it) * 1991-06-05 1994-10-25 Sigma Tau Ind Farmaceuti 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2100641A1 (en) * 1992-07-23 1994-01-24 Hiromu Matsumura Novel piperidine derivatives and process for preparation thereof
EP0951468A4 (en) * 1996-11-22 2001-06-06 Mona Industries Inc SILICONE MONOMERS AND OLIGOMERS CONTAINING A CARBOXYL FUNCTIONAL GROUP
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
CN102227217A (zh) 2008-10-16 2011-10-26 约翰斯.霍普金斯大学 改善认知功能的方法和组合物
EP2533645B1 (en) * 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
NL8004025A (nl) * 1979-08-09 1981-02-11 Hoffmann La Roche Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel.
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
BE892942A (fr) * 1982-04-23 1982-10-25 Ucb Sa Procede pour prevenir ou attenuer les psychoses iatrogenes causees par les medicaments a activite cytostatique.

Also Published As

Publication number Publication date
IT1152287B (it) 1986-12-31
HK53788A (en) 1988-07-22
GB2152038A (en) 1985-07-31
EP0071216A2 (de) 1983-02-09
US4476308B1 (ro) 1987-03-10
FI75158B (fi) 1988-01-29
GB2152038B (en) 1986-01-02
FR2515179B1 (ro) 1985-01-18
NL8202922A (nl) 1983-02-16
EP0071216A3 (en) 1983-09-07
IL66341A (en) 1986-12-31
EP0071216B1 (de) 1986-12-30
PT75314B (en) 1985-11-29
NO159592C (no) 1989-01-18
CA1176251A (en) 1984-10-16
NO159592B (no) 1988-10-10
SE8204445D0 (sv) 1982-07-23
IT8222335A1 (it) 1984-01-09
US4650878A (en) 1987-03-17
IL66341A0 (en) 1982-11-30
DD202540A5 (de) 1983-09-21
DE3274851D1 (en) 1987-02-05
DK317382A (da) 1983-01-25
OA07151A (fr) 1984-03-31
LU84294A1 (de) 1984-03-22
IT8222335A0 (it) 1982-07-09
DE3227649A1 (de) 1983-02-10
PH19149A (en) 1986-01-15
AT384424B (de) 1987-11-10
SU1281172A3 (ru) 1986-12-30
GB8426076D0 (en) 1984-11-21
ATE24488T1 (de) 1987-01-15
ATA286382A (de) 1987-04-15
FI822543L (fi) 1983-01-25
US5034402A (en) 1991-07-23
AU8615882A (en) 1983-01-27
CS226746B2 (en) 1984-04-16
NO822222L (no) 1983-01-25
ZW14482A1 (en) 1983-02-09
ES8307743A1 (es) 1983-08-16
HU187777B (en) 1986-02-28
BG38334A3 (en) 1985-11-15
PT75314A (en) 1982-08-01
SG22788G (en) 1988-07-15
DK157848C (da) 1990-07-23
GB2110207A (en) 1983-06-15
MC1476A1 (fr) 1983-06-17
RO84097A (ro) 1984-05-12
FI75158C (fi) 1988-05-09
AU557651B2 (en) 1987-01-08
US4476308A (en) 1984-10-09
FI822543A0 (fi) 1982-07-19
GB2110207B (en) 1985-09-04
IE53428B1 (en) 1988-11-09
ES514267A0 (es) 1983-08-16
SE8204445L (sv) 1983-01-25
IE821768L (en) 1983-01-24
DK157848B (da) 1990-02-26
EG15921A (en) 1986-09-30
NZ201297A (en) 1985-12-13
MTP915B (en) 1985-12-28
FR2515179A1 (fr) 1983-04-29

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