FI822543A0 - Pyrrolidinderivat - Google Patents

Pyrrolidinderivat

Info

Publication number
FI822543A0
FI822543A0 FI822543A FI822543A FI822543A0 FI 822543 A0 FI822543 A0 FI 822543A0 FI 822543 A FI822543 A FI 822543A FI 822543 A FI822543 A FI 822543A FI 822543 A0 FI822543 A0 FI 822543A0
Authority
FI
Finland
Prior art keywords
formula
hydrogen
useful
iii
pyrrolidinderivat
Prior art date
Application number
FI822543A
Other languages
English (en)
Other versions
FI75158B (fi
FI75158C (fi
FI822543L (fi
Inventor
Werner Aschwanden
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH4849/81A external-priority patent/CH647234A5/de
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI822543A0 publication Critical patent/FI822543A0/fi
Publication of FI822543L publication Critical patent/FI822543L/fi
Publication of FI75158B publication Critical patent/FI75158B/fi
Application granted granted Critical
Publication of FI75158C publication Critical patent/FI75158C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
FI822543A 1981-07-24 1982-07-19 Foerfarande foer framstaellning av pyrrolidinderivat samt i foerfarande anvaendbara mellanprodukter. FI75158C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH484981 1981-07-24
CH4849/81A CH647234A5 (en) 1981-07-24 1981-07-24 Pyrrolidine derivatives
CH276882 1982-05-05
CH276882 1982-05-05

Publications (4)

Publication Number Publication Date
FI822543A0 true FI822543A0 (fi) 1982-07-19
FI822543L FI822543L (fi) 1983-01-25
FI75158B FI75158B (fi) 1988-01-29
FI75158C FI75158C (fi) 1988-05-09

Family

ID=25691358

Family Applications (1)

Application Number Title Priority Date Filing Date
FI822543A FI75158C (fi) 1981-07-24 1982-07-19 Foerfarande foer framstaellning av pyrrolidinderivat samt i foerfarande anvaendbara mellanprodukter.

Country Status (34)

Country Link
US (3) US4476308A (fi)
EP (1) EP0071216B1 (fi)
AT (2) AT384424B (fi)
AU (1) AU557651B2 (fi)
BG (1) BG38334A3 (fi)
CA (1) CA1176251A (fi)
CS (1) CS226746B2 (fi)
DD (1) DD202540A5 (fi)
DE (2) DE3274851D1 (fi)
DK (1) DK157848C (fi)
EG (1) EG15921A (fi)
ES (1) ES8307743A1 (fi)
FI (1) FI75158C (fi)
FR (1) FR2515179A1 (fi)
GB (2) GB2110207B (fi)
HK (1) HK53788A (fi)
HU (1) HU187777B (fi)
IE (1) IE53428B1 (fi)
IL (1) IL66341A (fi)
IT (1) IT1152287B (fi)
LU (1) LU84294A1 (fi)
MC (1) MC1476A1 (fi)
MT (1) MTP915B (fi)
NL (1) NL8202922A (fi)
NO (1) NO159592C (fi)
NZ (1) NZ201297A (fi)
OA (1) OA07151A (fi)
PH (1) PH19149A (fi)
PT (1) PT75314B (fi)
RO (1) RO84097B (fi)
SE (1) SE8204445L (fi)
SG (1) SG22788G (fi)
SU (1) SU1281172A3 (fi)
ZW (1) ZW14482A1 (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173763B (it) * 1984-03-30 1987-06-24 Proter Spa Derivati dell'acido 3-mercapto-2-oxo-1-pirrolidinacetico,procedimento di preparazione e composizioni farmaceutiche che li contengono
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US4758585A (en) * 1985-08-16 1988-07-19 Warner-Lambert Company Saturated cycloalkyl (B) pyrrol-1 (2H)- acetic acid amides and derivatives thereof
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
CA1322199C (en) * 1987-07-15 1993-09-14 Masami Eigyo N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia
JPS6422883A (en) * 1987-07-17 1989-01-25 Sanwa Kagaku Kenkyusho Co 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
WO1989010359A1 (en) * 1988-04-22 1989-11-02 2 Moskovsky Gosudarstvenny Meditsinsky Institut Im Carbalkoxymethyl ethers of lactam-1-acetic acid and method of obtaining them
IT1245870B (it) * 1991-06-05 1994-10-25 Sigma Tau Ind Farmaceuti 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2100641A1 (en) * 1992-07-23 1994-01-24 Hiromu Matsumura Novel piperidine derivatives and process for preparation thereof
CA2272557A1 (en) * 1996-11-22 1998-05-28 Dennis L. Fost Silicone monomers and oligomers having a carboxyl functional group thereon
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
US6686477B2 (en) * 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
EA033130B1 (ru) 2008-10-16 2019-08-30 Дзе Джонс Хопкинс Юниверсити Способы и композиции для улучшения когнитивной функции
BR112012019923A2 (pt) * 2010-02-09 2016-08-09 Univ Johns Hopkins métodos e composições para melhorar a função cognitiva
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
NL8004025A (nl) * 1979-08-09 1981-02-11 Hoffmann La Roche Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel.
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
BE892942A (fr) * 1982-04-23 1982-10-25 Ucb Sa Procede pour prevenir ou attenuer les psychoses iatrogenes causees par les medicaments a activite cytostatique.

Also Published As

Publication number Publication date
AU8615882A (en) 1983-01-27
EP0071216B1 (de) 1986-12-30
HK53788A (en) 1988-07-22
DD202540A5 (de) 1983-09-21
RO84097A (ro) 1984-05-12
FR2515179A1 (fr) 1983-04-29
GB2110207B (en) 1985-09-04
NL8202922A (nl) 1983-02-16
GB2152038B (en) 1986-01-02
GB8426076D0 (en) 1984-11-21
DE3227649A1 (de) 1983-02-10
PT75314A (en) 1982-08-01
RO84097B (ro) 1984-06-30
NZ201297A (en) 1985-12-13
EP0071216A2 (de) 1983-02-09
SE8204445L (sv) 1983-01-25
ATA286382A (de) 1987-04-15
GB2152038A (en) 1985-07-31
OA07151A (fr) 1984-03-31
ATE24488T1 (de) 1987-01-15
ZW14482A1 (en) 1983-02-09
IT8222335A1 (it) 1984-01-09
ES514267A0 (es) 1983-08-16
CS226746B2 (en) 1984-04-16
SG22788G (en) 1988-07-15
DE3274851D1 (en) 1987-02-05
EP0071216A3 (en) 1983-09-07
IL66341A (en) 1986-12-31
MTP915B (en) 1985-12-28
DK157848B (da) 1990-02-26
AU557651B2 (en) 1987-01-08
DK317382A (da) 1983-01-25
FI75158B (fi) 1988-01-29
US4476308A (en) 1984-10-09
PH19149A (en) 1986-01-15
US5034402A (en) 1991-07-23
IL66341A0 (en) 1982-11-30
IE821768L (en) 1983-01-24
MC1476A1 (fr) 1983-06-17
SU1281172A3 (ru) 1986-12-30
GB2110207A (en) 1983-06-15
NO159592B (no) 1988-10-10
PT75314B (en) 1985-11-29
IE53428B1 (en) 1988-11-09
DK157848C (da) 1990-07-23
AT384424B (de) 1987-11-10
FI75158C (fi) 1988-05-09
IT8222335A0 (it) 1982-07-09
FI822543L (fi) 1983-01-25
US4650878A (en) 1987-03-17
US4476308B1 (fi) 1987-03-10
NO159592C (no) 1989-01-18
BG38334A3 (en) 1985-11-15
NO822222L (no) 1983-01-25
FR2515179B1 (fi) 1985-01-18
CA1176251A (en) 1984-10-16
ES8307743A1 (es) 1983-08-16
SE8204445D0 (sv) 1982-07-23
IT1152287B (it) 1986-12-31
EG15921A (en) 1986-09-30
HU187777B (en) 1986-02-28
LU84294A1 (de) 1984-03-22

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE AG