NZ618277A - Uracil or thymine derivative for treating hepatitis c - Google Patents

Uracil or thymine derivative for treating hepatitis c

Info

Publication number
NZ618277A
NZ618277A NZ618277A NZ61827708A NZ618277A NZ 618277 A NZ618277 A NZ 618277A NZ 618277 A NZ618277 A NZ 618277A NZ 61827708 A NZ61827708 A NZ 61827708A NZ 618277 A NZ618277 A NZ 618277A
Authority
NZ
New Zealand
Prior art keywords
uracil
compounds
disclosed
thymine
dihydropyrimidin
Prior art date
Application number
NZ618277A
Other languages
English (en)
Inventor
Douglas K Hutchinson
David M Barnes
Rolf Wagner
Michael D Tufano
John K Pratt
Christopher E Motter
Kenton L Longenecker
Peggy P Huang
David A Betebenner
Yi Gao
Ii Thaddeus S Franczyk
Todd W Rockway
Rodger F Henry
Brian J Kotecki
Xiaochun Lou
John T Randolph
Charles A Flentge
Kent D Stewart
Clarence J Maring
Yaya Liu
Dachun Liu
Allan C Krueger
Warren M Kati
David A Degoey
Pamela L Donner
Anthony R Haight
Kathy Sarris
Geoff G Z Zhang
John E Hengeveld
Shuang Chen
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39948002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ618277(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of NZ618277A publication Critical patent/NZ618277A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
NZ618277A 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c NZ618277A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97287707P 2007-09-17 2007-09-17
US9679108P 2008-09-13 2008-09-13
NZ600371A NZ600371A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c

Publications (1)

Publication Number Publication Date
NZ618277A true NZ618277A (en) 2015-07-31

Family

ID=39948002

Family Applications (3)

Application Number Title Priority Date Filing Date
NZ618277A NZ618277A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c
NZ584720A NZ584720A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c
NZ600371A NZ600371A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c

Family Applications After (2)

Application Number Title Priority Date Filing Date
NZ584720A NZ584720A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c
NZ600371A NZ600371A (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c

Country Status (30)

Country Link
US (3) US8415351B2 (en:Method)
EP (2) EP2222646B1 (en:Method)
JP (2) JP5734654B2 (en:Method)
KR (2) KR101552474B1 (en:Method)
CN (2) CN102746239B (en:Method)
AR (2) AR070027A1 (en:Method)
AU (1) AU2008302448B2 (en:Method)
BR (1) BRPI0816994B8 (en:Method)
CA (2) CA2976793A1 (en:Method)
CL (2) CL2008002794A1 (en:Method)
CO (1) CO6260076A2 (en:Method)
CR (2) CR11316A (en:Method)
DO (2) DOP2010000084A (en:Method)
ES (1) ES2453591T3 (en:Method)
GT (1) GT201000061A (en:Method)
IL (1) IL204547A (en:Method)
IN (1) IN2012DN05113A (en:Method)
MX (2) MX2010002905A (en:Method)
MY (1) MY162760A (en:Method)
NZ (3) NZ618277A (en:Method)
PA (1) PA8796201A1 (en:Method)
PE (2) PE20090705A1 (en:Method)
PH (1) PH12013500365A1 (en:Method)
RU (2) RU2543620C2 (en:Method)
SG (1) SG183733A1 (en:Method)
TW (2) TWI534137B (en:Method)
UA (1) UA117800C2 (en:Method)
UY (1) UY31344A1 (en:Method)
WO (1) WO2009039127A1 (en:Method)
ZA (2) ZA201204224B (en:Method)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2639226B1 (en) * 2007-09-17 2016-08-31 AbbVie Bahamas Ltd. Anti-infective pyrimidines and uses thereof
MX2010002904A (es) 2007-09-17 2010-06-02 Abbott Lab N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
KR101552474B1 (ko) 2007-09-17 2015-09-11 애브비 바하마스 리미티드 Ｃ형 간염 치료용 우라실 또는 티민 유도체
MX2010005356A (es) * 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
CN102099335A (zh) 2008-07-23 2011-06-15 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
JP2012503620A (ja) 2008-09-26 2012-02-09 エフ．ホフマン−ラ ロシュ アーゲー Ｈｃｖを処置するためのピリンまたはピラジン誘導体
JP5744003B2 (ja) * 2009-03-24 2015-07-01 アッヴィ・バハマズ・リミテッド 抗ウイルス化合物を調製する方法
CN102448952B (zh) * 2009-03-25 2014-10-29 Abbvie公司 抗病毒化合物和其用途
JP2012522013A (ja) * 2009-03-27 2012-09-20 ザ ユーエービー リサーチ ファウンデーション 調節ｉｒｅｓ媒介翻訳
AU2010240888A1 (en) 2009-04-25 2011-11-17 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
TWI428332B (zh) 2009-06-09 2014-03-01 Hoffmann La Roche 雜環抗病毒化合物
AU2010264802A1 (en) * 2009-06-24 2012-01-19 F. Hoffmann-La Roche Ag Heterocyclic antiviral compound
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
BR112012005616A2 (pt) 2009-09-21 2016-06-21 Hoffmann La Roche compostos antivirais heterocíclicos
CN102639504A (zh) * 2009-11-21 2012-08-15 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
TW201144298A (en) * 2009-12-14 2011-12-16 Hoffmann La Roche Heterocyclic antiviral compounds
US9216952B2 (en) * 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
BR112013000245A2 (pt) 2010-07-07 2016-05-24 Hoffmann La Roche compostos antivirais heterocíclicos
AU2015201698B2 (en) * 2010-07-16 2017-02-02 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
MX2013000623A (es) * 2010-07-16 2013-06-13 Abbvie Inc Proceso para la preparación de compuestos antivirales.
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8841487B2 (en) 2010-07-16 2014-09-23 Abbvie Inc. Phosphine ligands for catalytic reactions
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体
RU2572835C2 (ru) 2010-08-13 2016-01-20 Ф. Хоффманн-Ля Рош Аг Производные (4-метилсульфониламинофенил)-хинолина, полезные при лечении гепатита с
CN102675092B (zh) * 2011-03-14 2014-11-05 江苏中丹药物研究有限公司 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法
EP2685964A1 (en) 2011-03-18 2014-01-22 AbbVie Inc. Formulations of phenyl uracil compounds
JP2014510743A (ja) * 2011-03-31 2014-05-01 シェファー、コンスタンツェ 核酸の非ウイルスの導入のためのパーフルオロ化化合物
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
JP5734124B2 (ja) * 2011-07-21 2015-06-10 株式会社 東邦アーステック １，３−ジヨードヒダントイン類の製造方法
JP5709999B2 (ja) 2011-08-01 2015-04-30 大日本住友製薬株式会社 ウラシル誘導体およびその医薬用途
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CN104436197A (zh) 2011-10-21 2015-03-25 艾伯维公司 至少两种直接作用抗病毒剂的组合产品
AR088463A1 (es) 2011-10-21 2014-06-11 Abbvie Inc Metodos para el tratamiento de hcv
AU2015200715A1 (en) * 2011-10-21 2015-03-05 Abbvie Ireland Unlimited Company Methods for treating HCV
AP3613A (en) 2012-05-15 2016-02-29 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 abl1abl2 bcr-abl1
BR112014027244A2 (pt) 2012-05-15 2017-06-27 Novartis Ag derivados de benzamida para inibição da atividade de abl1, abl2 e bcr-abl1
MX2014013373A (es) 2012-05-15 2015-08-14 Novartis Ag Derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1.
US9315489B2 (en) 2012-05-15 2016-04-19 Novartis Ag Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
CA2876496A1 (en) 2012-06-27 2014-01-03 Abbvie Inc. Methods for treating hcv
WO2014031791A1 (en) 2012-08-21 2014-02-27 Abbvie Inc. Process for preparing antiviral compounds
BR112015008927A2 (pt) 2012-10-18 2017-07-04 Abbvie Inc formulações de compostos derivados de pirimidinadiona
JP2014101316A (ja) * 2012-11-20 2014-06-05 Toyobo Co Ltd ベンゾ［１，２−ｄ；４，５−ｄ’］ビスチアゾール化合物の製造方法
CA2916912A1 (en) 2013-07-02 2015-01-08 Abbvie Inc. Methods for treating hcv
ES2728531T3 (es) 2013-07-08 2019-10-25 Bayer Cropscience Ag Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con C-N como agentes para combatir parásitos
PL3043803T3 (pl) 2013-09-11 2022-11-07 Emory University Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
EP3099295A1 (en) 2014-01-28 2016-12-07 Abbvie Inc. Dose adjustment in combination therapy of hepatitis c
CN105940002B (zh) 2014-02-03 2018-09-25 生命医药公司 ROR-γ的二氢吡咯并吡啶抑制剂
CN106065009B (zh) * 2014-06-28 2019-03-01 广东东阳光药业有限公司 作为丙型肝炎抑制剂的化合物及其在药物中的应用
WO2016004513A1 (en) * 2014-07-11 2016-01-14 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
CN106573915B (zh) 2014-08-01 2020-12-25 纽韦卢森公司 针对布罗莫结构域有活性的化合物
WO2016040588A1 (en) 2014-09-11 2016-03-17 Abbvie Inc. Treatment of hcv by administering four different anti-hcv compounds with food
DK3207043T6 (da) 2014-10-14 2020-01-20 Vitae Pharmaceuticals Llc Dihydropyrrolopyridin-inhibitorer af ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
RU2590952C1 (ru) * 2015-05-26 2016-07-10 Вячеслав Энгельсович Семёнов Средство гепатопротекторного действия
WO2016196280A1 (en) 2015-06-02 2016-12-08 E I Du Pont De Nemours And Company Heterocycle-substituted bicyclic pesticides
JP2018525371A (ja) * 2015-07-30 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アリール置換された二環式ヘテロアリール化合物
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
AU2016355710B2 (en) 2015-11-20 2021-03-25 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US11192914B2 (en) 2016-04-28 2021-12-07 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
SG11202000621VA (en) 2017-07-24 2020-02-27 Vitae Pharmaceuticals Llc Inhibitors of ror?
CN107266373A (zh) * 2017-08-01 2017-10-20 安徽拜善晟制药有限公司 一种原料药达沙布韦的制备方法
JP7252973B2 (ja) 2018-03-26 2023-04-05 ノバルティス アーゲー Ｎ－（３－（７Ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）フェニル）ベンズアミド誘導体
CN110483496B (zh) * 2019-07-17 2021-05-04 杭州市西溪医院 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用
US20220387602A1 (en) * 2019-09-16 2022-12-08 Novartis Ag Bifunctional degraders and their methods of use
EP3819006A1 (en) 2019-11-05 2021-05-12 Technische Universität Dresden Compounds with thymine skeleton for use in medicine
CN111518036A (zh) * 2020-04-29 2020-08-11 杭州勇诚睿生物科技有限公司 一种达沙布韦关键中间体的制备方法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) * 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
US5084084A (en) * 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
DE69129998T2 (de) 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
NL9001075A (en:Method) * 1990-05-04 1991-12-02 Duphar Int Res
EP0489480A1 (en) * 1990-12-05 1992-06-10 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
RU2266901C2 (ru) 1999-12-06 2005-12-27 Ф.Хоффманн-Ля Рош Аг 4-пиримидинил-n-ацил-l-фенилаланины и фармацевтическая композиция
US6380387B1 (en) * 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
IL167954A (en) * 2000-02-04 2007-10-31 Sumitomo Chemical Co History of pyrimidine
RU2264395C2 (ru) * 2000-02-04 2005-11-20 Сумитомо Кемикал Компани, Лимитед Производные урацила, гербицидная композиция, способ борьбы с сорняками и промежуточные продукты (варианты)
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR100589964B1 (ko) * 2003-06-13 2006-06-19 주식회사 엘지생명과학 Ｃ형 간염 바이러스의 억제제
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
TWI394747B (zh) * 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
EP2639226B1 (en) * 2007-09-17 2016-08-31 AbbVie Bahamas Ltd. Anti-infective pyrimidines and uses thereof
MX2010002904A (es) 2007-09-17 2010-06-02 Abbott Lab N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
KR101552474B1 (ko) 2007-09-17 2015-09-11 애브비 바하마스 리미티드 Ｃ형 간염 치료용 우라실 또는 티민 유도체
CN102099335A (zh) 2008-07-23 2011-06-15 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物

Also Published As

Publication number Publication date
NZ600371A (en) 2014-07-25
US20120213733A1 (en) 2012-08-23
KR101660360B1 (ko) 2016-09-27
IL204547A0 (en) 2010-11-30
ZA201204223B (en) 2015-12-23
UA117800C2 (uk) 2018-10-10
BRPI0816994A2 (pt) 2015-03-24
DOP2010000396A (es) 2013-12-31
CA2976793A1 (en) 2009-03-26
MX2010002905A (es) 2010-07-05
PH12013500365A1 (en) 2014-09-08
CR11316A (es) 2010-10-05
MY162760A (en) 2017-07-14
CR20150238A (es) 2015-07-01
EP2725015A1 (en) 2014-04-30
KR101552474B1 (ko) 2015-09-11
IL204547A (en) 2016-04-21
US8685991B2 (en) 2014-04-01
CN102746239A (zh) 2012-10-24
TW200918066A (en) 2009-05-01
CA2699981C (en) 2017-08-22
BRPI0816994B1 (pt) 2019-12-24
TW201443027A (zh) 2014-11-16
EP2222646B1 (en) 2014-01-22
RU2010114828A (ru) 2011-10-27
CA2699981A1 (en) 2009-03-26
CN101801935A (zh) 2010-08-11
AR087472A2 (es) 2014-03-26
JP2010539186A (ja) 2010-12-16
US20110070193A1 (en) 2011-03-24
AU2008302448A1 (en) 2009-03-26
PE20130209A1 (es) 2013-03-24
CN102746239B (zh) 2016-02-10
US20140235638A1 (en) 2014-08-21
AU2008302448B2 (en) 2014-11-06
BRPI0816994B8 (pt) 2021-05-25
RU2013104270A (ru) 2014-08-10
ES2453591T3 (es) 2014-04-08
RU2543620C2 (ru) 2015-03-10
JP5734654B2 (ja) 2015-06-17
IN2012DN05113A (en:Method) 2015-10-23
HK1147256A1 (en) 2011-08-05
CL2013000372A1 (es) 2013-10-04
MX338555B (es) 2016-04-20
CN101801935B (zh) 2014-12-03
JP2013049681A (ja) 2013-03-14
ZA201204224B (en) 2015-12-23
US8415351B2 (en) 2013-04-09
NZ584720A (en) 2012-07-27
KR20150117632A (ko) 2015-10-20
AR070027A1 (es) 2010-03-10
TWI534137B (zh) 2016-05-21
DOP2010000084A (es) 2010-06-15
GT201000061A (es) 2012-03-26
WO2009039127A1 (en) 2009-03-26
PA8796201A1 (es) 2009-04-23
US9095590B2 (en) 2015-08-04
EP2222646A1 (en) 2010-09-01
CL2008002794A1 (es) 2009-09-04
RU2599635C2 (ru) 2016-10-10
PE20090705A1 (es) 2009-07-17
TWI437994B (zh) 2014-05-21
KR20100068289A (ko) 2010-06-22
CO6260076A2 (es) 2011-03-22
SG183733A1 (en) 2012-09-27
UY31344A1 (es) 2009-04-30

Similar Documents

Publication Publication Date Title
NZ618277A (en) Uracil or thymine derivative for treating hepatitis c
GB0413087D0 (en) Therapeutic compounds
NO20091409L (no) Pyridin-3-yl-derivater som immunmodulerende midler
NO20091394L (no) Pyridin-4-yl-derivater som immunmodulerende midler
MX2009003316A (es) Derivados de pirazina-2-carboxamida como moduladores receptores de cb2.
NO20071642L (no) N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger
NO20073465L (no) Benzotiazol-derivater
PE20130242A1 (es) Derivados de isoxazolo-piridina
PH12012501817A1 (en) Polysubstituted derivatives of 6-heteroaryl-imidazo[1,2-a] pyridines, and preparation and therapeutic use thereof
CY1111425T1 (el) ΠΑΡΑΓΩΓΑ ΤΗΣ ΠΥΡΙΔΟ[2,1-a]-ΙΣΟΚΙΝΟΛΙΝΗΣ ΩΣ DPP-IV ΑΝΑΣΤΟΛΕΙΣ
NZ597544A (en) Modified 4'-nucleosides as antiviral agents
MY135841A (en) Novel benzodioxoles
NO20054905L (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
CY1112921T1 (el) Ενεργοποιητες γλυκοκινασης πυρρολιδινονης
MXPA05013733A (es) 2-aminobenzotiazoles como agonistas inversos del receptor de cb1.
MX2008016423A (es) Arilamidas sustituidas con tetrazol.
TW200833686A (en) Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
BRPI0410445A (pt) inibidores de amida de ácido pirrolopiridina-2-carboxìlico de glicogênio fosforilase
NO20082496L (no) Pyrazinderivater
MX2009012613A (es) Tiazoles substituidos por heteroarilo y su uso como agentes antivirales.
MX2011006843A (es) Dihidropiridona-amidas como moduladores de p2x7.
MX2010009922A (es) Activadores de piridazinona glucocinasa.
BRPI0810402A2 (pt) Derivados de pirrolidina como antagonistas duais dos receptores nk1/nk3
NO20075270L (no) Antibakterielle amid-makrocykler V
ATE384058T1 (de) Thiazolderivate

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 6 YEARS UNTIL 17 SEP 2018 BY AJ PARK

Effective date: 20160224

ASS Change of ownership

Owner name: ABBVIE IRELAND UNLIMITED COMPANY, BM

Effective date: 20170223

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2019 BY THOMSON REUTERS

Effective date: 20180816

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2020 BY THOMSON REUTERS

Effective date: 20190817

LAPS Patent lapsed