NO20075270L - Antibakterielle amid-makrocykler V - Google Patents

Antibakterielle amid-makrocykler V

Info

Publication number
NO20075270L
NO20075270L NO20075270A NO20075270A NO20075270L NO 20075270 L NO20075270 L NO 20075270L NO 20075270 A NO20075270 A NO 20075270A NO 20075270 A NO20075270 A NO 20075270A NO 20075270 L NO20075270 L NO 20075270L
Authority
NO
Norway
Prior art keywords
macrocycles
represents hydrogen
antibacterial amide
prophylaxis
diseases
Prior art date
Application number
NO20075270A
Other languages
English (en)
Inventor
Rainer Endermann
Siegfried Raddatz
Kerstin Ehlert
Martin Michels
Yolanda Cancho-Grande
Stefan Weigand
Karin Fischer
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of NO20075270L publication Critical patent/NO20075270L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår antibakterielle amidmakrosykler med formel (I) hvori R26 representerer hydrogen, halogen, amino eller metyl, R7 representerer en gruppe med formel (II), (III), (IV) eller (V), hvor R1 representerer hydrogen eller hydroksy og * står for bindingspunktet på karbonatomet og R2 representerer hydrogen eller metyl. Oppfinnelsen angår også en fremgangsmåte for fremstilling av nevnte makrosykler, deres anvendelse for behandling og/eller profylakse av sykdommer, og deres anvendelse for fremstilling av medikamenter for behandling og/eller profylakse av sykdommer, særlig bakterielle infeksjoner.
NO20075270A 2005-03-30 2007-10-15 Antibakterielle amid-makrocykler V NO20075270L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005014245A DE102005014245A1 (de) 2005-03-30 2005-03-30 Antibakterielle Amid-Makrozyklen V
PCT/EP2006/002617 WO2006103015A1 (de) 2005-03-30 2006-03-22 Antibakterielle amid-makrozyklen v

Publications (1)

Publication Number Publication Date
NO20075270L true NO20075270L (no) 2007-12-18

Family

ID=36572224

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075270A NO20075270L (no) 2005-03-30 2007-10-15 Antibakterielle amid-makrocykler V

Country Status (17)

Country Link
US (1) US20080275018A1 (no)
EP (1) EP1869068A1 (no)
JP (1) JP2008534540A (no)
KR (1) KR20070116169A (no)
CN (1) CN101228182A (no)
AU (1) AU2006228751A1 (no)
BR (1) BRPI0612219A2 (no)
CA (1) CA2602755A1 (no)
DE (1) DE102005014245A1 (no)
IL (1) IL185899A0 (no)
MX (1) MX2007012146A (no)
NO (1) NO20075270L (no)
NZ (1) NZ562003A (no)
RU (1) RU2409588C2 (no)
UA (1) UA91541C2 (no)
WO (1) WO2006103015A1 (no)
ZA (1) ZA200709336B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
JP2013539751A (ja) 2010-09-15 2013-10-28 ザ スクリプス リサーチ インスティチュート 広域抗生物質アリロマイシン類縁体
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
US20140249073A1 (en) * 2011-05-27 2014-09-04 Rqx Pharmaceuticals, Inc Broad spectrum antibiotics
WO2014081886A1 (en) 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2017084629A1 (en) 2015-11-20 2017-05-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
EP3672939A1 (en) 2017-08-21 2020-07-01 Celgene Corporation Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
IL288294B (en) 2019-05-28 2022-09-01 Hoffmann La Roche A broad-spectrum macrocyclic antibiotic

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
WO2005033129A1 (de) * 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibakterielle amid-makrozyklen
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
CA2602755A1 (en) 2006-10-05
IL185899A0 (en) 2008-12-29
BRPI0612219A2 (pt) 2009-01-13
JP2008534540A (ja) 2008-08-28
EP1869068A1 (de) 2007-12-26
US20080275018A1 (en) 2008-11-06
UA91541C2 (ru) 2010-08-10
AU2006228751A1 (en) 2006-10-05
ZA200709336B (en) 2009-09-30
WO2006103015A1 (de) 2006-10-05
DE102005014245A1 (de) 2006-10-05
CN101228182A (zh) 2008-07-23
RU2007139760A (ru) 2009-05-10
NZ562003A (en) 2010-11-26
RU2409588C2 (ru) 2011-01-20
MX2007012146A (es) 2007-12-10
KR20070116169A (ko) 2007-12-06

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application