MX2007012146A - Amida-macrociclos v antibacterianos. - Google Patents

Amida-macrociclos v antibacterianos.

Info

Publication number
MX2007012146A
MX2007012146A MX2007012146A MX2007012146A MX2007012146A MX 2007012146 A MX2007012146 A MX 2007012146A MX 2007012146 A MX2007012146 A MX 2007012146A MX 2007012146 A MX2007012146 A MX 2007012146A MX 2007012146 A MX2007012146 A MX 2007012146A
Authority
MX
Mexico
Prior art keywords
sup
macrocycles
represents hydrogen
prophylaxis
diseases
Prior art date
Application number
MX2007012146A
Other languages
English (en)
Inventor
Rainer Endermann
Kerstin Ehlert
Siegfried Raddatz
Martin Michels
Yolanda Cancho-Grande
Stefan Weigand
Karin Fischer
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of MX2007012146A publication Critical patent/MX2007012146A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invencion se refiere a macrociclos amida antibacterianos de formula (I), donde R26 representa hidrogeno, halogeno, amino o metileno, R7 representa un grupo de formula (II), (III), (IV) o (V), donde R1 representa hidrogeno o hidroxi y * es el sitio de union al atomo de carbono, R2 representa hidrogeno o metilo y metodos para su produccion, su uso para el tratamiento y/o profilaxis y de enfermedades asi como su uso en la produccion de medicamentos para el tratamiento y/o profilaxis de enfermedades, en particular de infecciones bacterianas.
MX2007012146A 2005-03-30 2006-03-22 Amida-macrociclos v antibacterianos. MX2007012146A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005014245A DE102005014245A1 (de) 2005-03-30 2005-03-30 Antibakterielle Amid-Makrozyklen V
PCT/EP2006/002617 WO2006103015A1 (de) 2005-03-30 2006-03-22 Antibakterielle amid-makrozyklen v

Publications (1)

Publication Number Publication Date
MX2007012146A true MX2007012146A (es) 2007-12-10

Family

ID=36572224

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012146A MX2007012146A (es) 2005-03-30 2006-03-22 Amida-macrociclos v antibacterianos.

Country Status (17)

Country Link
US (1) US20080275018A1 (es)
EP (1) EP1869068A1 (es)
JP (1) JP2008534540A (es)
KR (1) KR20070116169A (es)
CN (1) CN101228182A (es)
AU (1) AU2006228751A1 (es)
BR (1) BRPI0612219A2 (es)
CA (1) CA2602755A1 (es)
DE (1) DE102005014245A1 (es)
IL (1) IL185899A0 (es)
MX (1) MX2007012146A (es)
NO (1) NO20075270L (es)
NZ (1) NZ562003A (es)
RU (1) RU2409588C2 (es)
UA (1) UA91541C2 (es)
WO (1) WO2006103015A1 (es)
ZA (1) ZA200709336B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
CN103209700A (zh) 2010-09-15 2013-07-17 斯克里普斯研究所 广谱抗生素Arylomycin类似物
US20140249073A1 (en) * 2011-05-27 2014-09-04 Rqx Pharmaceuticals, Inc Broad spectrum antibiotics
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CN104903302B (zh) 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
WO2015179441A2 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
ES2961566T3 (es) 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
NZ562003A (en) 2010-11-26
CA2602755A1 (en) 2006-10-05
BRPI0612219A2 (pt) 2009-01-13
UA91541C2 (ru) 2010-08-10
WO2006103015A1 (de) 2006-10-05
RU2409588C2 (ru) 2011-01-20
DE102005014245A1 (de) 2006-10-05
JP2008534540A (ja) 2008-08-28
IL185899A0 (en) 2008-12-29
RU2007139760A (ru) 2009-05-10
ZA200709336B (en) 2009-09-30
EP1869068A1 (de) 2007-12-26
NO20075270L (no) 2007-12-18
US20080275018A1 (en) 2008-11-06
CN101228182A (zh) 2008-07-23
AU2006228751A1 (en) 2006-10-05
KR20070116169A (ko) 2007-12-06

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