BRPI0612219A2 - macrociclos amida v antibacterianos - Google Patents
macrociclos amida v antibacterianosInfo
- Publication number
- BRPI0612219A2 BRPI0612219A2 BRPI0612219-1A BRPI0612219A BRPI0612219A2 BR PI0612219 A2 BRPI0612219 A2 BR PI0612219A2 BR PI0612219 A BRPI0612219 A BR PI0612219A BR PI0612219 A2 BRPI0612219 A2 BR PI0612219A2
- Authority
- BR
- Brazil
- Prior art keywords
- macrocycles
- represents hydrogen
- antibacterial amide
- antibacterial
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Macrociclos amida V antibacterianos. O presente invento se refere a macrociclos amida antibacterianos de fórmula (I) em que R^ 26^ representa hidrogênio, halogênio, amina ou metila, R^ 7^ representa um grupo de fórmula (II), (III), (IV) ou (V), em que R¹ representa hidrogénio ou hidroxila e * é o sítio de união ao átomo de carbono, R² representa hidrogênio ou metila e métodos para sua produção, seu uso para o tratamento e/ou profilaxia de enfermidades assim como seu uso na produção de medicamentos para o tratamento e/ou profilaxia de enfermidades, em particular de infecções bacterianas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005014245A DE102005014245A1 (de) | 2005-03-30 | 2005-03-30 | Antibakterielle Amid-Makrozyklen V |
PCT/EP2006/002617 WO2006103015A1 (de) | 2005-03-30 | 2006-03-22 | Antibakterielle amid-makrozyklen v |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0612219A2 true BRPI0612219A2 (pt) | 2009-01-13 |
Family
ID=36572224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0612219-1A BRPI0612219A2 (pt) | 2005-03-30 | 2006-03-22 | macrociclos amida v antibacterianos |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080275018A1 (pt) |
EP (1) | EP1869068A1 (pt) |
JP (1) | JP2008534540A (pt) |
KR (1) | KR20070116169A (pt) |
CN (1) | CN101228182A (pt) |
AU (1) | AU2006228751A1 (pt) |
BR (1) | BRPI0612219A2 (pt) |
CA (1) | CA2602755A1 (pt) |
DE (1) | DE102005014245A1 (pt) |
IL (1) | IL185899A0 (pt) |
MX (1) | MX2007012146A (pt) |
NO (1) | NO20075270L (pt) |
NZ (1) | NZ562003A (pt) |
RU (1) | RU2409588C2 (pt) |
UA (1) | UA91541C2 (pt) |
WO (1) | WO2006103015A1 (pt) |
ZA (1) | ZA200709336B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10358824A1 (de) | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
DE102005032781A1 (de) * | 2005-07-14 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Markozyklen VII |
EP2616093A4 (en) | 2010-09-15 | 2014-02-26 | Scripps Research Inst | IN A WIDE SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGUE |
US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
WO2012166665A2 (en) * | 2011-05-27 | 2012-12-06 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
JP6437443B2 (ja) | 2012-11-21 | 2018-12-12 | アールキューエックス ファーマシューティカルズ,インク. | 大環状広域抗生物質 |
CN106661084B (zh) | 2014-05-20 | 2021-08-31 | 阿奇克斯制药公司 | 大环广谱抗生素 |
JP6873993B2 (ja) | 2015-11-20 | 2021-05-19 | アールキューエックス ファーマシューティカルズ,インク. | 大環状広域抗生物質 |
EP3388444A1 (en) * | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Anti-bacterial peptide macrocycles and use thereof |
EP3672939A1 (en) | 2017-08-21 | 2020-07-01 | Celgene Corporation | Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate |
US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
BR112021024010A2 (pt) | 2019-05-28 | 2022-05-17 | Hoffmann La Roche | Antibióticos macrocíclicos de amplo espectro |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3452136A (en) * | 1968-04-17 | 1969-06-24 | American Cyanamid Co | Antibiotic af283 and production thereof |
FR2720066B1 (fr) * | 1994-05-20 | 1996-06-28 | Rhone Poulenc Rorer Sa | Peptides antagonistes de la neurotensine. |
DE10226921A1 (de) * | 2002-06-17 | 2003-12-24 | Bayer Ag | Antibakterielle Amid-Makrozyklen |
DE10234422A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Antibakterielle Ester-Makrozyklen |
JP2008502583A (ja) * | 2003-10-01 | 2008-01-31 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 抗細菌性アミド大員環 |
DE10358824A1 (de) * | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
DE102005014240A1 (de) * | 2004-09-24 | 2006-03-30 | Bayer Healthcare Ag | Antibakterielle Amid-Makrozyklen IV |
-
2005
- 2005-03-30 DE DE102005014245A patent/DE102005014245A1/de not_active Withdrawn
-
2006
- 2006-03-22 CA CA002602755A patent/CA2602755A1/en not_active Abandoned
- 2006-03-22 WO PCT/EP2006/002617 patent/WO2006103015A1/de active Application Filing
- 2006-03-22 AU AU2006228751A patent/AU2006228751A1/en not_active Abandoned
- 2006-03-22 MX MX2007012146A patent/MX2007012146A/es not_active Application Discontinuation
- 2006-03-22 RU RU2007139760/04A patent/RU2409588C2/ru not_active IP Right Cessation
- 2006-03-22 KR KR1020077025008A patent/KR20070116169A/ko not_active Application Discontinuation
- 2006-03-22 UA UAA200711765A patent/UA91541C2/ru unknown
- 2006-03-22 ZA ZA200709336A patent/ZA200709336B/xx unknown
- 2006-03-22 BR BRPI0612219-1A patent/BRPI0612219A2/pt not_active IP Right Cessation
- 2006-03-22 CN CNA2006800188391A patent/CN101228182A/zh active Pending
- 2006-03-22 EP EP06723614A patent/EP1869068A1/de not_active Withdrawn
- 2006-03-22 NZ NZ562003A patent/NZ562003A/en unknown
- 2006-03-22 JP JP2008503408A patent/JP2008534540A/ja not_active Withdrawn
-
2007
- 2007-09-11 IL IL185899A patent/IL185899A0/en unknown
- 2007-09-28 US US11/906,088 patent/US20080275018A1/en not_active Abandoned
- 2007-10-15 NO NO20075270A patent/NO20075270L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2602755A1 (en) | 2006-10-05 |
AU2006228751A1 (en) | 2006-10-05 |
NZ562003A (en) | 2010-11-26 |
NO20075270L (no) | 2007-12-18 |
IL185899A0 (en) | 2008-12-29 |
CN101228182A (zh) | 2008-07-23 |
DE102005014245A1 (de) | 2006-10-05 |
ZA200709336B (en) | 2009-09-30 |
MX2007012146A (es) | 2007-12-10 |
KR20070116169A (ko) | 2007-12-06 |
UA91541C2 (ru) | 2010-08-10 |
WO2006103015A1 (de) | 2006-10-05 |
RU2409588C2 (ru) | 2011-01-20 |
JP2008534540A (ja) | 2008-08-28 |
EP1869068A1 (de) | 2007-12-26 |
RU2007139760A (ru) | 2009-05-10 |
US20080275018A1 (en) | 2008-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0612219A2 (pt) | macrociclos amida v antibacterianos | |
BRPI0813244B8 (pt) | compostos derivados de pirazinona, composições compreendendo ditos compostos, uso dos compostos no tratamento de doenças de pulmão e composto intermediário | |
BRPI0921701B8 (pt) | Cefarosporina tendo um grupo catecol, seu uso e composição farmacêutica que a compreende | |
BR112013028813A2 (pt) | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas | |
BR112013032974A2 (pt) | "derivados de 1,6-diazabiciclo [3,2,1]-octan-7-ona, seus usos, e composições farmacêuticas". | |
TW200745070A (en) | Novel 1,4-benzothiazepine 1,1-dioxide derivative with improved properties, process for its preparation, medicaments comprising this compound and their use | |
BR112012015916A2 (pt) | derivados de pirazina e seu uso no tratamento de distúrbios neurológicos | |
BRPI0621693B8 (pt) | compostos derivados de benzotiazinona, composição farmacêutica, e seu uso como agentes antibacterianos | |
CR20140392A (es) | Dihidropirazolonas sustituidas | |
BRPI1009637A2 (pt) | composto, composição e uso de um composto | |
BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
BRPI1011657A2 (pt) | derivados aminopropiônicos substituídos como inibidores de neprilisina | |
BR112015018751A2 (pt) | derivados de piridazinona macrocíclicos | |
EA200870193A1 (ru) | Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение | |
CY1112429T1 (el) | Υποκατεστημενα παραγωγα σουλφοναμιδιου | |
BR112012013854A2 (pt) | derivados de oxazina. | |
MX2010008460A (es) | Derivado de tiazol y su uso como inhibidor de proteina-1 de adhesion vascular. | |
BRPI0518907A2 (pt) | compostos, processo para a sua manufatura, composiÇÕes farmacÊuticas que os compreendem, mÉtodo para o tratamento e/ou prevenÇço de enfermidades que estço associadas com a modulaÇço de receptores de h3 e sua utilizaÇço | |
BRPI0408353A (pt) | composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto | |
BRPI0519351A2 (pt) | medicamentos para o tratamento ou prevenÇço de doenÇas fibràticas | |
BR112012006172A2 (pt) | derivados de alqueno oxindol e seus usos para o tratamento de obesidade, diabetes e hiperlipidemia | |
BRPI0913291A2 (pt) | composto, pró-droga, medicamento, métodos para diminuir a proteína 4 ou tratamento de diabete em um mamífero, e, uso do composto | |
ME00961B (me) | Derivati-7 alkinil-1,8-naftiridoni, njihova priprema i njihova primjena u liječenju | |
MA32375B1 (fr) | Derives de 5-hydroxymethyl-oxazolidine-2-one pour le traitement de maladies intestinales bacteriennes | |
BRPI0519854A2 (pt) | 4- feniltetraidroquinolinas substituìdas, métodos para produzì-las, seu uso como fármaco, e fármaco contendo-as |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2213 DE 04/06/2013. |