NZ575167A - Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors - Google Patents

Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

Info

Publication number
NZ575167A
NZ575167A NZ575167A NZ57516706A NZ575167A NZ 575167 A NZ575167 A NZ 575167A NZ 575167 A NZ575167 A NZ 575167A NZ 57516706 A NZ57516706 A NZ 57516706A NZ 575167 A NZ575167 A NZ 575167A
Authority
NZ
New Zealand
Prior art keywords
amino
pyrimidin
methyl
trans
group
Prior art date
Application number
NZ575167A
Other languages
English (en)
Inventor
Hengmiao Cheng
Dilip Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabeth Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Mitchell David Nambu
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NZ575167A publication Critical patent/NZ575167A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
NZ575167A 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors NZ575167A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (en) 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

Publications (1)

Publication Number Publication Date
NZ575167A true NZ575167A (en) 2010-10-29

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ575167A NZ575167A (en) 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

Country Status (41)

Country Link
US (3) US7696213B2 (enExample)
EP (1) EP2074122B9 (enExample)
JP (1) JP4718637B2 (enExample)
KR (1) KR101099926B1 (enExample)
CN (1) CN101573358B (enExample)
AP (1) AP2710A (enExample)
AR (1) AR062785A1 (enExample)
AT (1) ATE514695T1 (enExample)
AU (1) AU2007297212B8 (enExample)
BR (1) BRPI0716749B8 (enExample)
CA (1) CA2663401C (enExample)
CL (1) CL2007002682A1 (enExample)
CR (1) CR10662A (enExample)
CU (1) CU23783B7 (enExample)
CY (1) CY1111911T1 (enExample)
DK (1) DK2074122T5 (enExample)
DO (1) DOP2009000039A (enExample)
EA (1) EA016388B1 (enExample)
ES (1) ES2366489T3 (enExample)
GE (1) GEP20115306B (enExample)
GT (1) GT200700077A (enExample)
HN (1) HN2007000267A (enExample)
HR (1) HRP20110621T2 (enExample)
IL (1) IL197243A (enExample)
MA (1) MA30709B1 (enExample)
ME (1) MEP8009A (enExample)
MX (1) MX2009002927A (enExample)
MY (1) MY146420A (enExample)
NI (1) NI200900032A (enExample)
NO (1) NO342357B1 (enExample)
NZ (1) NZ575167A (enExample)
PE (1) PE20080670A1 (enExample)
PL (1) PL2074122T3 (enExample)
PT (1) PT2074122E (enExample)
RS (2) RS20090104A (enExample)
SI (1) SI2074122T1 (enExample)
TN (1) TN2009000085A1 (enExample)
TW (1) TWI334353B (enExample)
UY (1) UY30588A1 (enExample)
WO (1) WO2008032162A1 (enExample)
ZA (1) ZA200901477B (enExample)

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Also Published As

Publication number Publication date
US20100137279A1 (en) 2010-06-03
WO2008032162A1 (en) 2008-03-20
EP2074122B1 (en) 2011-06-29
JP4718637B2 (ja) 2011-07-06
NO342357B1 (no) 2018-05-14
CR10662A (es) 2009-04-17
HN2007000267A (es) 2011-02-25
DK2074122T5 (da) 2014-03-17
EA016388B1 (ru) 2012-04-30
US20080090801A1 (en) 2008-04-17
JP2010503653A (ja) 2010-02-04
BRPI0716749B1 (pt) 2020-10-06
CU20090040A7 (es) 2011-07-11
EP2074122B9 (en) 2013-09-11
NI200900032A (es) 2010-05-14
PE20080670A1 (es) 2008-06-14
IL197243A (en) 2013-07-31
ES2366489T3 (es) 2011-10-20
ATE514695T1 (de) 2011-07-15
ZA200901477B (en) 2010-07-28
CA2663401C (en) 2011-07-12
US8633204B2 (en) 2014-01-21
NO20091141L (no) 2009-03-31
RS20090104A (sr) 2010-06-30
GEP20115306B (enExample) 2011-10-10
CN101573358A (zh) 2009-11-04
KR20090040389A (ko) 2009-04-23
EA200970207A1 (ru) 2009-08-28
AP2710A (en) 2013-07-30
HK1138589A1 (en) 2010-08-27
CU23783B7 (es) 2012-02-15
AP2009004790A0 (en) 2009-04-30
CY1111911T1 (el) 2015-11-04
MX2009002927A (es) 2009-03-31
US7696213B2 (en) 2010-04-13
UY30588A1 (es) 2008-05-02
TWI334353B (en) 2010-12-11
AU2007297212A1 (en) 2008-03-20
MEP8009A (en) 2011-12-20
PT2074122E (pt) 2011-08-24
KR101099926B1 (ko) 2011-12-28
TN2009000085A1 (fr) 2010-08-19
CN101573358B (zh) 2012-05-30
RS51927B (sr) 2012-02-29
HRP20110621T2 (hr) 2013-12-06
CA2663401A1 (en) 2008-03-20
BRPI0716749A2 (pt) 2014-02-18
MA30709B1 (fr) 2009-09-01
ES2366489T9 (es) 2013-12-27
US8273755B2 (en) 2012-09-25
WO2008032162A8 (en) 2009-03-26
IL197243A0 (en) 2009-12-24
AR062785A1 (es) 2008-12-03
TW200820972A (en) 2008-05-16
AU2007297212B8 (en) 2011-04-28
AU2007297212B2 (en) 2011-04-14
GT200700077A (es) 2009-08-03
MY146420A (en) 2012-08-15
BRPI0716749B8 (pt) 2021-05-25
HRP20110621T1 (hr) 2011-09-30
CL2007002682A1 (es) 2008-04-04
SI2074122T1 (sl) 2011-10-28
EP2074122A1 (en) 2009-07-01
DK2074122T3 (da) 2011-08-15
PL2074122T3 (pl) 2011-10-31
DOP2009000039A (es) 2015-12-15
US20120309775A1 (en) 2012-12-06

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