HRP20110621T2 - SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3 - Google Patents

SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3 Download PDF

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Publication number
HRP20110621T2
HRP20110621T2 HRP20110621TT HRP20110621T HRP20110621T2 HR P20110621 T2 HRP20110621 T2 HR P20110621T2 HR P20110621T T HRP20110621T T HR P20110621TT HR P20110621 T HRP20110621 T HR P20110621T HR P20110621 T2 HRP20110621 T2 HR P20110621T2
Authority
HR
Croatia
Prior art keywords
amino
methyl
pyrimidin
cyclohexyl
trans
Prior art date
Application number
HRP20110621TT
Other languages
English (en)
Croatian (hr)
Inventor
Hengmiao Cheng
Dilip Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabet Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HRP20110621T1 publication Critical patent/HRP20110621T1/xx
Publication of HRP20110621T2 publication Critical patent/HRP20110621T2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
HRP20110621TT 2006-09-15 2007-09-03 SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3 HRP20110621T2 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (en) 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

Publications (2)

Publication Number Publication Date
HRP20110621T1 HRP20110621T1 (hr) 2011-09-30
HRP20110621T2 true HRP20110621T2 (hr) 2013-12-06

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20110621TT HRP20110621T2 (hr) 2006-09-15 2007-09-03 SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3

Country Status (41)

Country Link
US (3) US7696213B2 (enExample)
EP (1) EP2074122B9 (enExample)
JP (1) JP4718637B2 (enExample)
KR (1) KR101099926B1 (enExample)
CN (1) CN101573358B (enExample)
AP (1) AP2710A (enExample)
AR (1) AR062785A1 (enExample)
AT (1) ATE514695T1 (enExample)
AU (1) AU2007297212B8 (enExample)
BR (1) BRPI0716749B8 (enExample)
CA (1) CA2663401C (enExample)
CL (1) CL2007002682A1 (enExample)
CR (1) CR10662A (enExample)
CU (1) CU23783B7 (enExample)
CY (1) CY1111911T1 (enExample)
DK (1) DK2074122T5 (enExample)
DO (1) DOP2009000039A (enExample)
EA (1) EA016388B1 (enExample)
ES (1) ES2366489T3 (enExample)
GE (1) GEP20115306B (enExample)
GT (1) GT200700077A (enExample)
HN (1) HN2007000267A (enExample)
HR (1) HRP20110621T2 (enExample)
IL (1) IL197243A (enExample)
MA (1) MA30709B1 (enExample)
ME (1) MEP8009A (enExample)
MX (1) MX2009002927A (enExample)
MY (1) MY146420A (enExample)
NI (1) NI200900032A (enExample)
NO (1) NO342357B1 (enExample)
NZ (1) NZ575167A (enExample)
PE (1) PE20080670A1 (enExample)
PL (1) PL2074122T3 (enExample)
PT (1) PT2074122E (enExample)
RS (2) RS51927B (enExample)
SI (1) SI2074122T1 (enExample)
TN (1) TN2009000085A1 (enExample)
TW (1) TWI334353B (enExample)
UY (1) UY30588A1 (enExample)
WO (1) WO2008032162A1 (enExample)
ZA (1) ZA200901477B (enExample)

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CN104829609B (zh) * 2014-02-11 2016-08-03 北大方正集团有限公司 取代的吡啶并嘧啶化合物及其制备方法和应用
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Also Published As

Publication number Publication date
HN2007000267A (es) 2011-02-25
CN101573358B (zh) 2012-05-30
DOP2009000039A (es) 2015-12-15
DK2074122T5 (da) 2014-03-17
WO2008032162A8 (en) 2009-03-26
EP2074122B9 (en) 2013-09-11
CU23783B7 (es) 2012-02-15
KR101099926B1 (ko) 2011-12-28
AP2710A (en) 2013-07-30
TW200820972A (en) 2008-05-16
ATE514695T1 (de) 2011-07-15
JP4718637B2 (ja) 2011-07-06
US20120309775A1 (en) 2012-12-06
NO342357B1 (no) 2018-05-14
PL2074122T3 (pl) 2011-10-31
UY30588A1 (es) 2008-05-02
MA30709B1 (fr) 2009-09-01
CA2663401C (en) 2011-07-12
US20080090801A1 (en) 2008-04-17
SI2074122T1 (sl) 2011-10-28
KR20090040389A (ko) 2009-04-23
JP2010503653A (ja) 2010-02-04
GT200700077A (es) 2009-08-03
NZ575167A (en) 2010-10-29
BRPI0716749B1 (pt) 2020-10-06
PT2074122E (pt) 2011-08-24
AU2007297212B8 (en) 2011-04-28
US7696213B2 (en) 2010-04-13
CA2663401A1 (en) 2008-03-20
EP2074122A1 (en) 2009-07-01
IL197243A0 (en) 2009-12-24
CR10662A (es) 2009-04-17
BRPI0716749A2 (pt) 2014-02-18
ES2366489T9 (es) 2013-12-27
US20100137279A1 (en) 2010-06-03
TWI334353B (en) 2010-12-11
CU20090040A7 (es) 2011-07-11
CY1111911T1 (el) 2015-11-04
AU2007297212A1 (en) 2008-03-20
WO2008032162A1 (en) 2008-03-20
RS51927B (sr) 2012-02-29
IL197243A (en) 2013-07-31
RS20090104A (sr) 2010-06-30
HK1138589A1 (en) 2010-08-27
CL2007002682A1 (es) 2008-04-04
PE20080670A1 (es) 2008-06-14
MEP8009A (en) 2011-12-20
MY146420A (en) 2012-08-15
CN101573358A (zh) 2009-11-04
MX2009002927A (es) 2009-03-31
ES2366489T3 (es) 2011-10-20
ZA200901477B (en) 2010-07-28
HRP20110621T1 (hr) 2011-09-30
US8633204B2 (en) 2014-01-21
TN2009000085A1 (fr) 2010-08-19
NO20091141L (no) 2009-03-31
EA016388B1 (ru) 2012-04-30
EP2074122B1 (en) 2011-06-29
AP2009004790A0 (en) 2009-04-30
AU2007297212B2 (en) 2011-04-14
DK2074122T3 (da) 2011-08-15
NI200900032A (es) 2010-05-14
EA200970207A1 (ru) 2009-08-28
GEP20115306B (enExample) 2011-10-10
US8273755B2 (en) 2012-09-25
BRPI0716749B8 (pt) 2021-05-25
AR062785A1 (es) 2008-12-03

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