CN101573358B - 吡啶并(2,3-d)嘧啶酮化合物及其作为pi3抑制剂的用途 - Google Patents

吡啶并(2,3-d)嘧啶酮化合物及其作为pi3抑制剂的用途 Download PDF

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CN101573358B
CN101573358B CN2007800342100A CN200780034210A CN101573358B CN 101573358 B CN101573358 B CN 101573358B CN 2007800342100 A CN2007800342100 A CN 2007800342100A CN 200780034210 A CN200780034210 A CN 200780034210A CN 101573358 B CN101573358 B CN 101573358B
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amino
methyl
compound
pyrimidines
cyclohexyl
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CN101573358A (zh
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恒淼·程
狄利普·布汉瑞卡尔
克劳斯·雷普瑞奇·卓斯
贾桂·伊丽莎白·霍夫曼
玛丽·凯萨琳·强森
罗伯特·史蒂文·卡尼亚
冯·席·奎·李
米契尔·大卫·奈布
马森·亚伦·派瑞许
麦可·布鲁诺·普雷威
可汉·图温·崔恩
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Pfizer Products Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
CN2007800342100A 2006-09-15 2007-09-03 吡啶并(2,3-d)嘧啶酮化合物及其作为pi3抑制剂的用途 Expired - Fee Related CN101573358B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US60/845,065 2006-09-15
US94785207P 2007-07-03 2007-07-03
US60/947,852 2007-07-03
US95262807P 2007-07-30 2007-07-30
US60/952,628 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (en) 2006-09-15 2007-09-03 Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors

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CN101573358A CN101573358A (zh) 2009-11-04
CN101573358B true CN101573358B (zh) 2012-05-30

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US7696213B2 (en) 2010-04-13
JP2010503653A (ja) 2010-02-04
US8633204B2 (en) 2014-01-21
WO2008032162A1 (en) 2008-03-20
AP2009004790A0 (en) 2009-04-30
US8273755B2 (en) 2012-09-25
BRPI0716749B1 (pt) 2020-10-06
HK1138589A1 (en) 2010-08-27
ZA200901477B (en) 2010-07-28
EA200970207A1 (ru) 2009-08-28
AU2007297212B2 (en) 2011-04-14
CN101573358A (zh) 2009-11-04
KR101099926B1 (ko) 2011-12-28
JP4718637B2 (ja) 2011-07-06
NZ575167A (en) 2010-10-29
MY146420A (en) 2012-08-15
CA2663401C (en) 2011-07-12
CU23783B7 (es) 2012-02-15
CY1111911T1 (el) 2015-11-04
EP2074122B1 (en) 2011-06-29
EP2074122A1 (en) 2009-07-01
NO20091141L (no) 2009-03-31
TW200820972A (en) 2008-05-16
RS51927B (sr) 2012-02-29
DK2074122T3 (da) 2011-08-15
ATE514695T1 (de) 2011-07-15
BRPI0716749A2 (pt) 2014-02-18
NO342357B1 (no) 2018-05-14
UY30588A1 (es) 2008-05-02
HN2007000267A (es) 2011-02-25
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