JP2004527560A5 - - Google Patents
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- Publication number
- JP2004527560A5 JP2004527560A5 JP2002585423A JP2002585423A JP2004527560A5 JP 2004527560 A5 JP2004527560 A5 JP 2004527560A5 JP 2002585423 A JP2002585423 A JP 2002585423A JP 2002585423 A JP2002585423 A JP 2002585423A JP 2004527560 A5 JP2004527560 A5 JP 2004527560A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopentylamino
- pyrazolo
- pyridin
- pyrimidinyl
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000006312 cyclopentyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 30
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 23
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 21
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- -1 1-pyrrolidinylcarbonyl Chemical group 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- RJAIATRJLAYBKS-UHFFFAOYSA-N 4-[5-chloro-3-[2-(cyclopentylamino)pyrimidin-4-yl]-7-(cyclopropylamino)pyrazolo[1,5-a]pyridin-2-yl]phenol Chemical compound C1=CC(O)=CC=C1C1=NN(C(NC2CC2)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 RJAIATRJLAYBKS-UHFFFAOYSA-N 0.000 claims 1
- WNWVKZTYMQWFHE-UHFFFAOYSA-N 4-ethylmorpholine Chemical group [CH2]CN1CCOCC1 WNWVKZTYMQWFHE-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- CNMBLWDXHYWTLA-UHFFFAOYSA-N 5-chloro-3-[2-(cyclopentylamino)pyrimidin-4-yl]-n-cyclopropyl-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(NC2CC2)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 CNMBLWDXHYWTLA-UHFFFAOYSA-N 0.000 claims 1
- WCKXXYWOSVAGLZ-UHFFFAOYSA-N 5-chloro-3-[2-(cyclopentylamino)pyrimidin-4-yl]-n-cyclopropyl-2-[4-(cyclopropylmethoxy)phenyl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound N12N=C(C=3C=CC(OCC4CC4)=CC=3)C(C=3N=C(NC4CCCC4)N=CC=3)=C2C=C(Cl)C=C1NC1CC1 WCKXXYWOSVAGLZ-UHFFFAOYSA-N 0.000 claims 1
- GLKWTXUVFUJIGX-UHFFFAOYSA-N 5-chloro-n-cyclopentyl-2-(4-methoxyphenyl)-3-(2-methylsulfanylpyrimidin-4-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(NC2CCCC2)=CC(Cl)=C2)C2=C1C1=CC=NC(SC)=N1 GLKWTXUVFUJIGX-UHFFFAOYSA-N 0.000 claims 1
- KMUNEVPPFFIIAM-UHFFFAOYSA-N 5-chloro-n-cyclopentyl-2-(4-methoxyphenyl)-3-(2-methylsulfinylpyrimidin-4-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(NC2CCCC2)=CC(Cl)=C2)C2=C1C1=CC=NC(S(C)=O)=N1 KMUNEVPPFFIIAM-UHFFFAOYSA-N 0.000 claims 1
- FVDIJBUKMLLPCL-UHFFFAOYSA-N 5-chloro-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C(NC2CCCC2)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 FVDIJBUKMLLPCL-UHFFFAOYSA-N 0.000 claims 1
- ARFXCYCTFNKRNL-UHFFFAOYSA-N 5-chloro-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(NC2CCCC2)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 ARFXCYCTFNKRNL-UHFFFAOYSA-N 0.000 claims 1
- KVWGXHFUCADPDK-UHFFFAOYSA-N 5-chloro-n-cyclopentyl-3-[2-(cyclopropylamino)pyrimidin-4-yl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(NC2CCCC2)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CC2)=N1 KVWGXHFUCADPDK-UHFFFAOYSA-N 0.000 claims 1
- ZIDVGKZMRABSOF-UHFFFAOYSA-N 7-(cyclopentylamino)-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-n-hydroxypyrazolo[1,5-a]pyridine-6-carboxamide Chemical compound ONC(=O)C=1C=CC2=C(C=3N=C(NC4CCCC4)N=CC=3)C(C=3C=CC(F)=CC=3)=NN2C=1NC1CCCC1 ZIDVGKZMRABSOF-UHFFFAOYSA-N 0.000 claims 1
- RWOYMYIYXMICCH-UHFFFAOYSA-N 7-chloro-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C(Cl)=CC(NC2CCCC2)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 RWOYMYIYXMICCH-UHFFFAOYSA-N 0.000 claims 1
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 claims 1
- 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 claims 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- FQNJTEQMAQMIMU-UHFFFAOYSA-N [7-(cyclopentylamino)-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl]methanol Chemical compound OCC=1C=CC2=C(C=3N=C(NC4CCCC4)N=CC=3)C(C=3C=CC(F)=CC=3)=NN2C=1NC1CCCC1 FQNJTEQMAQMIMU-UHFFFAOYSA-N 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- JQTSLEMPHVXCDY-UHFFFAOYSA-N ethyl 7-(cyclopentylamino)-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-6-carboxylate Chemical compound CCOC(=O)C=1C=CC2=C(C=3N=C(NC4CCCC4)N=CC=3)C(C=3C=CC(F)=CC=3)=NN2C=1NC1CCCC1 JQTSLEMPHVXCDY-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- OJDKXSZDDHEORF-UHFFFAOYSA-N n-cyclopentyl-2-(4-fluorophenyl)-3-(2-pyrrolidin-1-ylpyrimidin-4-yl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C(NC2CCCC2)=C(C=C2)C(F)(F)F)C2=C1C1=CC=NC(N2CCCC2)=N1 OJDKXSZDDHEORF-UHFFFAOYSA-N 0.000 claims 1
- ZKYXVDDZBFULBP-UHFFFAOYSA-N n-cyclopentyl-4-[5,7-dichloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-amine Chemical compound C1=CC(F)=CC=C1C1=NN(C(Cl)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 ZKYXVDDZBFULBP-UHFFFAOYSA-N 0.000 claims 1
- UPURSWNGJDCEHG-UHFFFAOYSA-N n-cyclopentyl-4-[5,7-dichloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-amine Chemical compound C1=CC(OC)=CC=C1C1=NN(C(Cl)=CC(Cl)=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 UPURSWNGJDCEHG-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28694801P | 2001-04-27 | 2001-04-27 | |
| PCT/US2002/010687 WO2002088124A2 (en) | 2001-04-27 | 2002-04-05 | Pyrazolo'1,5-a!pyridine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527560A JP2004527560A (ja) | 2004-09-09 |
| JP2004527560A5 true JP2004527560A5 (enExample) | 2005-08-18 |
Family
ID=23100830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585423A Pending JP2004527560A (ja) | 2001-04-27 | 2002-04-05 | ピラゾロ［１，５−α］ピリジン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6962914B2 (enExample) |
| EP (1) | EP1385847B1 (enExample) |
| JP (1) | JP2004527560A (enExample) |
| AT (1) | ATE296826T1 (enExample) |
| AU (1) | AU2002305143A1 (enExample) |
| DE (1) | DE60204452T2 (enExample) |
| ES (1) | ES2242028T3 (enExample) |
| WO (1) | WO2002088124A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| EP1377573B1 (en) * | 2000-12-15 | 2005-07-27 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| US7153855B2 (en) * | 2001-03-08 | 2006-12-26 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyrimidine therapeutic compounds |
| JP4219171B2 (ja) * | 2001-04-10 | 2009-02-04 | スミスクライン ビーチャム コーポレーション | 抗ウイルス性ピラゾロピリジン化合物 |
| ES2286272T3 (es) * | 2001-09-07 | 2007-12-01 | Smithkline Beecham Corporation | Pirizolo-piridinas para el tratamiento de infecciones por herpes. |
| WO2003050120A1 (en) * | 2001-12-11 | 2003-06-19 | Smithkline Beecham Corporation | Pyrazolo-pyridine derivatives as antiherpes agents |
| ATE302203T1 (de) | 2002-03-07 | 2005-09-15 | Smithkline Beecham Corp | Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen |
| WO2006055245A2 (en) * | 2004-11-17 | 2006-05-26 | Smithkline Beecham Corporation | Process for preparing pyrazolopyridine compounds |
| US7812022B2 (en) * | 2004-12-21 | 2010-10-12 | Glaxosmithkline Llc | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors |
| WO2007067506A2 (en) * | 2005-12-05 | 2007-06-14 | Smithkline Beecham Corporation | 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| EP2448938B9 (en) | 2009-06-29 | 2015-06-10 | Incyte Corporation | Pyrimidinones as pi3k inhibitors |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
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| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| EP2402335A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| EP2402336A1 (en) | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| JP5961187B2 (ja) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン |
| EP2667874A4 (en) * | 2011-01-27 | 2014-07-30 | Univ Princeton | MTOR KINASE HEMMER AS ANTIVIRUS AGENT |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
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| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| BR112017003745A2 (pt) | 2014-08-29 | 2017-12-05 | Tes Pharma S R L | inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico |
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| US20180057486A1 (en) | 2016-08-29 | 2018-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| EP4223369A1 (en) | 2016-12-22 | 2023-08-09 | Incyte Corporation | Immunomodulator compounds and methods of use |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| US10308644B2 (en) | 2016-12-22 | 2019-06-04 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SMT202300065T1 (it) | 2018-03-30 | 2023-05-12 | Incyte Corp | Composti eterociclici come immunomodulatori |
| CN112752756B (zh) | 2018-05-11 | 2024-06-25 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
| IL278889B2 (en) | 2018-06-01 | 2025-11-01 | Incyte Corp | Dosing regimen for the treatment of pi3k related disorders |
| TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽 |
| JP7559059B2 (ja) | 2019-09-30 | 2024-10-01 | インサイト・コーポレイション | 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 |
| EP4058461A1 (en) | 2019-11-11 | 2022-09-21 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
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Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0151962A3 (en) * | 1984-01-25 | 1985-10-02 | Beecham Group Plc | Pyrazolopyridine derivatives |
| GB8404586D0 (en) * | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| GB8404584D0 (en) * | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| US5002941A (en) | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
| US4925849A (en) * | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
| US5155114A (en) * | 1989-01-23 | 1992-10-13 | Fujisawa Pharmaceutical Company, Ltd. | Method of treatment using pyrazolopyridine compound |
| GB8901423D0 (en) | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| KR920702621A (ko) | 1989-06-13 | 1992-10-06 | 스튜어트 알. 슈터 | 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제 |
| AU622330B2 (en) * | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| EP0533837A4 (en) | 1990-06-12 | 1994-11-17 | Smithkline Beecham Corp | Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases |
| GB9015764D0 (en) * | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| ATE211384T1 (de) | 1991-01-29 | 2002-01-15 | Fujisawa Pharmaceutical Co | Verwendung von adenosinantagonisten zur vorbeugung und behandlung von pankreatitis und ulcera |
| GB9107513D0 (en) * | 1991-04-10 | 1991-05-29 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| US5300478A (en) * | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5497774A (en) * | 1993-11-03 | 1996-03-12 | Daig Corporation | Guiding introducer for left atrium |
| CN1046724C (zh) * | 1993-12-29 | 1999-11-24 | 藤泽药品工业株式会社 | 吡唑并吡啶化合物、含有它们的药物组合物、及其制法与用途 |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| NZ304886A (en) | 1995-04-04 | 1998-11-25 | Glaxo Group Ltd | Imidazo [1,2a] pyridine derivatives, preparation and pharmaceutical compositions thereof |
| US6342510B1 (en) | 1995-06-12 | 2002-01-29 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist |
| ATE301457T1 (de) * | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| US5700816A (en) * | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
| US5670432A (en) | 1996-08-01 | 1997-09-23 | Taiwan Semiconductor Manufacturing Company, Ltd. | Thermal treatment to form a void free aluminum metal layer for a semiconductor device |
| FR2757166B1 (fr) * | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757059B1 (fr) | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouvelle application therapeutique des derives du pyrrole |
| US20020156104A1 (en) * | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| ATE281458T1 (de) | 1997-09-05 | 2004-11-15 | Glaxo Group Ltd | Pharmazeutische zusammensetzung, enthaltend 2,3- diaryl-pyrazolo(1,5-b)pyridazin derivate |
| WO1999058523A1 (en) | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| FR2779724B1 (fr) * | 1998-06-10 | 2001-04-20 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| ATE275148T1 (de) | 1998-11-03 | 2004-09-15 | Glaxo Group Ltd | Pyrazolopyridin derivative als selektive cox-2 inhibitoren |
| WO2000052008A1 (en) | 1999-02-27 | 2000-09-08 | Glaxo Group Limited | Pyrazolopyridines |
| JP2003503403A (ja) | 1999-06-28 | 2003-01-28 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 呼吸合胞体ウイルス複製阻害剤 |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| US7075927B2 (en) * | 2000-05-05 | 2006-07-11 | Fujitsu Limited | Method and system for quality of service (QoS) support in a packet-switched network |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| AUPQ969800A0 (en) | 2000-08-28 | 2000-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| US20020114274A1 (en) * | 2000-09-19 | 2002-08-22 | Sturges James H. | Packet based network for supporting real time applications |
| EP1377573B1 (en) | 2000-12-15 | 2005-07-27 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| ES2245380T3 (es) | 2000-12-15 | 2006-01-01 | Glaxo Group Limited | Pirazolopiridinas. |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| CA2450555A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
| US7042841B2 (en) * | 2001-07-16 | 2006-05-09 | International Business Machines Corporation | Controlling network congestion using a biased packet discard policy for congestion control and encoded session packets: methods, systems, and program products |
| US6711762B2 (en) | 2002-01-30 | 2004-03-30 | Ktk Services, Inc. | Method of using a truck cab bridge bed |
| US7701934B2 (en) * | 2004-11-02 | 2010-04-20 | At&T Intellectual Property I, L.P. | System and method for managing devices within a private network via a public network |
| US20060092833A1 (en) * | 2004-11-02 | 2006-05-04 | Bemmel Jeroen V | Congestion control for improved management of service level agreements in switched networks |
-
2002
- 2002-04-05 AU AU2002305143A patent/AU2002305143A1/en not_active Abandoned
- 2002-04-05 WO PCT/US2002/010687 patent/WO2002088124A2/en not_active Ceased
- 2002-04-05 AT AT02733945T patent/ATE296826T1/de not_active IP Right Cessation
- 2002-04-05 US US10/473,751 patent/US6962914B2/en not_active Expired - Fee Related
- 2002-04-05 JP JP2002585423A patent/JP2004527560A/ja active Pending
- 2002-04-05 EP EP02733945A patent/EP1385847B1/en not_active Expired - Lifetime
- 2002-04-05 DE DE60204452T patent/DE60204452T2/de not_active Expired - Fee Related
- 2002-04-05 ES ES02733945T patent/ES2242028T3/es not_active Expired - Lifetime
-
2005
- 2005-03-31 US US11/095,212 patent/US7030134B2/en not_active Expired - Fee Related
- 2005-03-31 US US11/095,361 patent/US20050192295A1/en not_active Abandoned
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