NO962783L - Trombopoietin - Google Patents

Trombopoietin

Info

Publication number
NO962783L
NO962783L NO962783A NO962783A NO962783L NO 962783 L NO962783 L NO 962783L NO 962783 A NO962783 A NO 962783A NO 962783 A NO962783 A NO 962783A NO 962783 L NO962783 L NO 962783L
Authority
NO
Norway
Prior art keywords
thrombopoietin
Prior art date
Application number
NO962783A
Other languages
English (en)
Other versions
NO326903B1 (no
NO962783D0 (no
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO962783D0 publication Critical patent/NO962783D0/no
Publication of NO962783L publication Critical patent/NO962783L/no
Publication of NO326903B1 publication Critical patent/NO326903B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO19962783A 1994-01-03 1996-07-02 Isolert mpl-ligandpolypeptid, isolert nukleinsyremolekyl, ekspresjonsvektor, vertscelle, fremgangsmate for fremstilling av mpl-ligand, antistoff og farmasoytisk preparat for behandling eller forebyggelse av trombocytopeni. NO326903B1 (no)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
PCT/US1994/014553 WO1995018858A1 (en) 1994-01-03 1994-12-28 Thrombopoietin

Publications (3)

Publication Number Publication Date
NO962783D0 NO962783D0 (no) 1996-07-02
NO962783L true NO962783L (no) 1996-09-03
NO326903B1 NO326903B1 (no) 2009-03-16

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19962783A NO326903B1 (no) 1994-01-03 1996-07-02 Isolert mpl-ligandpolypeptid, isolert nukleinsyremolekyl, ekspresjonsvektor, vertscelle, fremgangsmate for fremstilling av mpl-ligand, antistoff og farmasoytisk preparat for behandling eller forebyggelse av trombocytopeni.

Country Status (28)

Country Link
EP (1) EP0738323A1 (no)
JP (2) JPH09508262A (no)
CN (1) CN1134539C (no)
AU (1) AU704266B2 (no)
BG (1) BG63639B1 (no)
CA (1) CA2178482C (no)
CZ (1) CZ296130B6 (no)
DK (1) DK149194A (no)
ES (1) ES2114786B1 (no)
FI (1) FI121573B (no)
FR (1) FR2714670B1 (no)
GB (1) GB2285446B (no)
HR (1) HRP941020A2 (no)
HU (1) HUT75657A (no)
IE (1) IE72517B1 (no)
IL (1) IL112184A (no)
IT (1) IT1283770B1 (no)
LU (1) LU88573A1 (no)
LV (1) LV11632B (no)
NL (1) NL9500010A (no)
NO (1) NO326903B1 (no)
NZ (1) NZ278726A (no)
PT (1) PT101627B (no)
RO (1) RO117110B1 (no)
SG (1) SG47030A1 (no)
SI (1) SI9420079A (no)
SK (1) SK282265B6 (no)
WO (1) WO1995018858A1 (no)

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US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
HU218893B (hu) * 1994-03-31 2000-12-28 Amgen Inc. A megakariocita szaporodás és differenciálódás stimulálására szolgáló módszerek és vízoldható készítmények
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
CA2212006A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. Novel c-mpl ligands
ATE323724T1 (de) * 1995-02-15 2006-05-15 Amgen Inc Mpl-liganden analoga
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EA001220B1 (ru) * 1995-06-07 2000-12-25 Глаксо Груп Лимитед Пептид или пептидомиметик, который связывается с рецептором тромбоэтина, фармацевтическая композиция и способ лечения
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
CA2262507A1 (en) * 1996-08-13 1998-02-19 Zymogenetics, Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
WO1998052598A1 (en) * 1997-05-21 1998-11-26 Genentech, Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
DE69934425T2 (de) 1998-10-23 2007-09-27 Amgen Inc., Thousand Oaks Thrombopoietin substitute
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
JP4087338B2 (ja) 2001-11-15 2008-05-21 キリンファーマ株式会社 キメラ非ヒト動物
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
BR0314591A (pt) 2002-09-18 2005-08-09 Ortho Mcneil Pharm Inc Métodos de aumento de plaquetas e produção de célula tronco hematopoiética
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
KR20120078742A (ko) 2003-08-28 2012-07-10 오르토-맥네일 파마슈티칼, 인코퍼레이티드 수용체에 결합하는 펩티드 및 화합물
EP1751298A4 (en) * 2004-05-18 2009-11-11 Intrexon Corp METHOD FOR DYNAMIC VECTOR ASSEMBLY OF DNA CLONING VECTOR PLASMIDES
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
EP2044197B8 (en) 2006-07-24 2018-03-07 The University Of Queensland Method of producing a population of cells
US8420779B2 (en) 2007-05-22 2013-04-16 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2010085086A2 (ko) 2009-01-20 2010-07-29 한올바이오파마 주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
EP3973967A1 (en) * 2012-12-21 2022-03-30 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
EP4036232A4 (en) * 2019-09-20 2023-01-11 Ractigen Therapeutics NUCLEIC ACID MOLECULE FOR THE TREATMENT OF IMMUNOTROMBOCYTOPENIA AND ITS USE
IL294098A (en) 2019-12-20 2022-08-01 Instil Bio Uk Ltd Devices and methods for isolating lymphocytes infiltrating tumors and their use

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
WO1993011247A1 (en) * 1991-12-06 1993-06-10 Genentech, Inc. Prohormone convertase transformed cells
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
FI962723A0 (fi) 1996-07-02
AU704266B2 (en) 1999-04-15
NZ278726A (en) 1998-06-26
IE950002A1 (en) 1995-07-12
ES2114786B1 (es) 1999-01-01
IL112184A (en) 2004-07-25
FR2714670B1 (fr) 1997-01-10
SG47030A1 (en) 1998-03-20
IE72517B1 (en) 1997-04-23
JPH10113186A (ja) 1998-05-06
NO326903B1 (no) 2009-03-16
ES2114786A1 (es) 1998-06-01
IT1283770B1 (it) 1998-04-30
DK149194A (da) 1995-07-04
HUT75657A (en) 1997-05-28
NO962783D0 (no) 1996-07-02
CA2178482A1 (en) 1995-07-13
JPH09508262A (ja) 1997-08-26
RO117110B1 (ro) 2001-10-30
CN1141061A (zh) 1997-01-22
LV11632B (en) 1997-04-20
FR2714670A1 (fr) 1995-07-07
BG100693A (en) 1998-01-30
CZ296130B6 (cs) 2006-01-11
BG63639B1 (bg) 2002-07-31
CA2178482C (en) 2012-01-03
GB2285446A (en) 1995-07-12
IL112184A0 (en) 1995-03-15
FI121573B (fi) 2011-01-14
NL9500010A (nl) 1995-08-01
AU1514695A (en) 1995-08-01
ITTO950002A0 (it) 1995-01-02
CZ192296A3 (en) 1997-05-14
EP0738323A1 (en) 1996-10-23
GB2285446B (en) 1999-07-28
LU88573A1 (de) 1995-06-01
FI962723A (fi) 1996-09-03
WO1995018858A1 (en) 1995-07-13
ITTO950002A1 (it) 1995-07-03
HRP941020A2 (en) 1997-04-30
HU9601805D0 (en) 1996-08-28
LV11632A (lv) 1996-12-20
GB9425831D0 (en) 1995-02-22
SK282265B6 (sk) 2001-12-03
PT101627A (pt) 1995-11-30
PT101627B (pt) 1996-11-29
SI9420079A (en) 1997-02-28
SK87596A3 (en) 1997-11-05
CN1134539C (zh) 2004-01-14

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