FI121573B - Menetelmä eristetyn mpl-ligandipolypeptidin valmistamiseksi - Google Patents

Menetelmä eristetyn mpl-ligandipolypeptidin valmistamiseksi Download PDF

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Publication number
FI121573B
FI121573B FI962723A FI962723A FI121573B FI 121573 B FI121573 B FI 121573B FI 962723 A FI962723 A FI 962723A FI 962723 A FI962723 A FI 962723A FI 121573 B FI121573 B FI 121573B
Authority
FI
Finland
Prior art keywords
seq
mpl ligand
mpl
ligand
sequence
Prior art date
Application number
FI962723A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962723A0 (fi
FI962723A (fi
Inventor
Sauvage Frederic J De
Dan L Eaton
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI962723A0 publication Critical patent/FI962723A0/fi
Publication of FI962723A publication Critical patent/FI962723A/fi
Application granted granted Critical
Publication of FI121573B publication Critical patent/FI121573B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI962723A 1994-01-03 1996-07-02 Menetelmä eristetyn mpl-ligandipolypeptidin valmistamiseksi FI121573B (fi)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US17655394 1994-01-03
US18560794A 1994-01-21 1994-01-21
US18560794 1994-01-21
US19668994 1994-02-15
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US22326394 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US24937694 1994-05-25
US34865894A 1994-12-02 1994-12-02
US34865894 1994-12-02
US34865794 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
US9414553 1994-12-28
PCT/US1994/014553 WO1995018858A1 (en) 1994-01-03 1994-12-28 Thrombopoietin

Publications (3)

Publication Number Publication Date
FI962723A0 FI962723A0 (fi) 1996-07-02
FI962723A FI962723A (fi) 1996-09-03
FI121573B true FI121573B (fi) 2011-01-14

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962723A FI121573B (fi) 1994-01-03 1996-07-02 Menetelmä eristetyn mpl-ligandipolypeptidin valmistamiseksi

Country Status (28)

Country Link
EP (1) EP0738323A1 (no)
JP (2) JPH09508262A (no)
CN (1) CN1134539C (no)
AU (1) AU704266B2 (no)
BG (1) BG63639B1 (no)
CA (1) CA2178482C (no)
CZ (1) CZ296130B6 (no)
DK (1) DK149194A (no)
ES (1) ES2114786B1 (no)
FI (1) FI121573B (no)
FR (1) FR2714670B1 (no)
GB (1) GB2285446B (no)
HR (1) HRP941020A2 (no)
HU (1) HUT75657A (no)
IE (1) IE72517B1 (no)
IL (1) IL112184A (no)
IT (1) IT1283770B1 (no)
LU (1) LU88573A1 (no)
LV (1) LV11632B (no)
NL (1) NL9500010A (no)
NO (1) NO326903B1 (no)
NZ (1) NZ278726A (no)
PT (1) PT101627B (no)
RO (1) RO117110B1 (no)
SG (1) SG47030A1 (no)
SI (1) SI9420079A (no)
SK (1) SK282265B6 (no)
WO (1) WO1995018858A1 (no)

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US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
WO1995021920A1 (en) * 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
KR100203824B1 (ko) * 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
US6254870B1 (en) 1995-02-03 2001-07-03 G. D. Searle & Co. Thrombopoietin: IL-3 fusion protein
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5696250A (en) 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
PL188795B1 (pl) * 1995-06-07 2005-04-29 Glaxo Group Ltd Związek wiążący się z receptorem trombopoetyny, kompozycja farmaceutyczna i zastosowanie związku wiążącego się z receptorem trombopoetyny
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
WO1998052598A1 (en) * 1997-05-21 1998-11-26 Genentech, Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
JP3820105B2 (ja) 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Ｍｐ１受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1994824A1 (en) 2001-11-15 2008-11-26 Kirin Pharma Kabushiki Kaisha Chimeric non-human animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
US8067367B2 (en) 2002-09-18 2011-11-29 Janssen Pharmaceutica, N.V. Methods of increasing platelet and hematopoietic stem cell production
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EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
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WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
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CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
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Also Published As

Publication number Publication date
CA2178482C (en) 2012-01-03
SG47030A1 (en) 1998-03-20
IL112184A (en) 2004-07-25
DK149194A (da) 1995-07-04
AU1514695A (en) 1995-08-01
CN1134539C (zh) 2004-01-14
LU88573A1 (de) 1995-06-01
ITTO950002A0 (it) 1995-01-02
LV11632B (en) 1997-04-20
ITTO950002A1 (it) 1995-07-03
NL9500010A (nl) 1995-08-01
HRP941020A2 (en) 1997-04-30
IT1283770B1 (it) 1998-04-30
CN1141061A (zh) 1997-01-22
NO326903B1 (no) 2009-03-16
SK282265B6 (sk) 2001-12-03
SI9420079A (en) 1997-02-28
HU9601805D0 (en) 1996-08-28
IE72517B1 (en) 1997-04-23
JPH09508262A (ja) 1997-08-26
FI962723A0 (fi) 1996-07-02
NO962783L (no) 1996-09-03
CA2178482A1 (en) 1995-07-13
EP0738323A1 (en) 1996-10-23
ES2114786A1 (es) 1998-06-01
PT101627B (pt) 1996-11-29
GB9425831D0 (en) 1995-02-22
JPH10113186A (ja) 1998-05-06
IE950002A1 (en) 1995-07-12
WO1995018858A1 (en) 1995-07-13
GB2285446B (en) 1999-07-28
BG100693A (en) 1998-01-30
AU704266B2 (en) 1999-04-15
CZ192296A3 (en) 1997-05-14
SK87596A3 (en) 1997-11-05
PT101627A (pt) 1995-11-30
NZ278726A (en) 1998-06-26
BG63639B1 (bg) 2002-07-31
HUT75657A (en) 1997-05-28
RO117110B1 (ro) 2001-10-30
CZ296130B6 (cs) 2006-01-11
FR2714670B1 (fr) 1997-01-10
ES2114786B1 (es) 1999-01-01
LV11632A (lv) 1996-12-20
IL112184A0 (en) 1995-03-15
FR2714670A1 (fr) 1995-07-07
GB2285446A (en) 1995-07-12
NO962783D0 (no) 1996-07-02
FI962723A (fi) 1996-09-03

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