LV11632A - Trombopoetins - Google Patents

Trombopoetins

Info

Publication number
LV11632A
LV11632A LV960315A LV960315A LV11632A LV 11632 A LV11632 A LV 11632A LV 960315 A LV960315 A LV 960315A LV 960315 A LV960315 A LV 960315A LV 11632 A LV11632 A LV 11632A
Authority
LV
Latvia
Prior art keywords
trombopoetins
Prior art date
Application number
LV960315A
Other languages
English (en)
Other versions
LV11632B (en
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of LV11632A publication Critical patent/LV11632A/lv
Publication of LV11632B publication Critical patent/LV11632B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
LVP-96-315A 1994-01-03 1996-07-24 Thrombopoietin LV11632B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
PCT/US1994/014553 WO1995018858A1 (en) 1994-01-03 1994-12-28 Thrombopoietin

Publications (2)

Publication Number Publication Date
LV11632A true LV11632A (lv) 1996-12-20
LV11632B LV11632B (en) 1997-04-20

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-315A LV11632B (en) 1994-01-03 1996-07-24 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (lv)
JP (2) JPH09508262A (lv)
CN (1) CN1134539C (lv)
AU (1) AU704266B2 (lv)
BG (1) BG63639B1 (lv)
CA (1) CA2178482C (lv)
CZ (1) CZ296130B6 (lv)
DK (1) DK149194A (lv)
ES (1) ES2114786B1 (lv)
FI (1) FI121573B (lv)
FR (1) FR2714670B1 (lv)
GB (1) GB2285446B (lv)
HR (1) HRP941020A2 (lv)
HU (1) HUT75657A (lv)
IE (1) IE72517B1 (lv)
IL (1) IL112184A (lv)
IT (1) IT1283770B1 (lv)
LU (1) LU88573A1 (lv)
LV (1) LV11632B (lv)
NL (1) NL9500010A (lv)
NO (1) NO326903B1 (lv)
NZ (1) NZ278726A (lv)
PT (1) PT101627B (lv)
RO (1) RO117110B1 (lv)
SG (1) SG47030A1 (lv)
SI (1) SI9420079A (lv)
SK (1) SK282265B6 (lv)
WO (1) WO1995018858A1 (lv)

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US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
KR100203824B1 (ko) * 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
EP0807181A1 (en) 1995-02-03 1997-11-19 G.D. Searle & Co. NOVEL c-MPL LIGANDS
DE69636052T2 (de) * 1995-02-15 2007-04-12 Amgen Inc., Thousand Oaks Mpl-liganden analoga
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
ZA964814B (en) * 1995-06-07 1998-02-09 Glaxo Group Ltd Peptides and compounds that bind to a receptor.
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
CA2262507A1 (en) * 1996-08-13 1998-02-19 Zymogenetics, Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
AU7589898A (en) * 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR100719202B1 (ko) 1998-10-23 2007-05-16 키린-암젠 인코포레이티드 ＭＰｌ 수용체에 결합하는 화합물 및 이를 함유하는 제약학적 조성물
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1452093A4 (en) 2001-11-15 2007-08-15 Kirin Brewery CHIMERIC ANIMALS
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
ES2781475T3 (es) 2002-09-18 2020-09-02 Janssen Pharmaceuticals Inc Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
BRPI0414008B8 (pt) 2003-08-28 2021-05-25 Ortho Mcneil Pharm Inc compostos que se ligam a um receptor de trombopoietina, composições e métodos in vitro para ativação de um receptor de trombopoietina em uma célula
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
EP1751298A4 (en) 2004-05-18 2009-11-11 Intrexon Corp METHOD FOR DYNAMIC VECTOR ASSEMBLY OF DNA CLONING VECTOR PLASMIDES
MX2007000216A (es) 2004-07-08 2007-03-15 Amgen Inc Peptidos terapeuticos.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
WO2008011664A1 (en) 2006-07-24 2008-01-31 The University Of Queensland Method of producing a population of cells
WO2008153745A2 (en) 2007-05-22 2008-12-18 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2010085086A2 (ko) 2009-01-20 2010-07-29 한올바이오파마 주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
ES2896354T3 (es) 2012-12-21 2022-02-24 Astellas Inst For Regenerative Medicine Métodos para la producción de plaquetas a partir de células madre pluripotentes
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
WO2021052470A1 (zh) * 2019-09-20 2021-03-25 中美瑞康核酸技术(南通)研究院有限公司 用于治疗血小板减少症的核酸分子及其应用
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

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US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
JPH07501703A (ja) * 1991-12-06 1995-02-23 ジェネンテク，インコーポレイテッド プロホルモンコンバターゼで形質転換された細胞およびポリペプチド合成
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
RO117110B1 (ro) 2001-10-30
NO326903B1 (no) 2009-03-16
ES2114786B1 (es) 1999-01-01
BG63639B1 (bg) 2002-07-31
NZ278726A (en) 1998-06-26
FI962723A0 (fi) 1996-07-02
LV11632B (en) 1997-04-20
JPH09508262A (ja) 1997-08-26
CN1141061A (zh) 1997-01-22
GB2285446B (en) 1999-07-28
AU704266B2 (en) 1999-04-15
LU88573A1 (de) 1995-06-01
HUT75657A (en) 1997-05-28
IL112184A0 (en) 1995-03-15
CZ192296A3 (en) 1997-05-14
JPH10113186A (ja) 1998-05-06
SK87596A3 (en) 1997-11-05
GB2285446A (en) 1995-07-12
FI121573B (fi) 2011-01-14
FR2714670B1 (fr) 1997-01-10
IL112184A (en) 2004-07-25
SK282265B6 (sk) 2001-12-03
DK149194A (da) 1995-07-04
PT101627B (pt) 1996-11-29
WO1995018858A1 (en) 1995-07-13
IT1283770B1 (it) 1998-04-30
CA2178482C (en) 2012-01-03
CZ296130B6 (cs) 2006-01-11
PT101627A (pt) 1995-11-30
SI9420079A (en) 1997-02-28
HU9601805D0 (en) 1996-08-28
EP0738323A1 (en) 1996-10-23
NO962783D0 (no) 1996-07-02
SG47030A1 (en) 1998-03-20
IE950002A1 (en) 1995-07-12
FI962723A (fi) 1996-09-03
AU1514695A (en) 1995-08-01
ITTO950002A0 (it) 1995-01-02
ES2114786A1 (es) 1998-06-01
GB9425831D0 (en) 1995-02-22
CN1134539C (zh) 2004-01-14
IE72517B1 (en) 1997-04-23
NL9500010A (nl) 1995-08-01
HRP941020A2 (en) 1997-04-30
ITTO950002A1 (it) 1995-07-03
FR2714670A1 (fr) 1995-07-07
NO962783L (no) 1996-09-03
BG100693A (en) 1998-01-30
CA2178482A1 (en) 1995-07-13

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