LV11632A - Trombopoetins - Google Patents



Publication number
LV11632A LV960315A LV960315A LV11632A LV 11632 A LV11632 A LV 11632A LV 960315 A LV960315 A LV 960315A LV 960315 A LV960315 A LV 960315A LV 11632 A LV11632 A LV 11632A
Prior art keywords
Prior art date
Application number
Other languages
Latvian (lv)
Other versions
LV11632B (en
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US17655394A priority Critical
Priority to US18560794A priority
Priority to US08/196,689 priority patent/US8357513B1/en
Priority to US22326394A priority
Priority to US08/249,376 priority patent/US8192955B1/en
Priority to US34865894A priority
Priority to US08/348,657 priority patent/US6660256B1/en
Priority to PCT/US1994/014553 priority patent/WO1995018858A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of LV11632A publication Critical patent/LV11632A/en
Publication of LV11632B publication Critical patent/LV11632B/en
First worldwide family litigation filed litigation Critical "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.



    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/524Thrombopoietin, i.e. C-MPL ligand
    • A61K38/00Medicinal preparations containing peptides
LV960315A 1994-01-03 1996-07-24 Thrombopoietin LV11632B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US17655394A true 1994-01-03 1994-01-03
US18560794A true 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A true 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A true 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
PCT/US1994/014553 WO1995018858A1 (en) 1994-01-03 1994-12-28 Thrombopoietin

Publications (2)

Publication Number Publication Date
LV11632A true LV11632A (en) 1996-12-20
LV11632B LV11632B (en) 1997-04-20



Family Applications (1)

Application Number Title Priority Date Filing Date
LV960315A LV11632B (en) 1994-01-03 1996-07-24 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (en)
JP (2) JPH09508262A (en)
CN (1) CN1134539C (en)
AU (1) AU704266B2 (en)
BG (1) BG63639B1 (en)
CA (1) CA2178482C (en)
CZ (1) CZ296130B6 (en)
DK (1) DK149194A (en)
ES (1) ES2114786B1 (en)
FI (1) FI121573B (en)
FR (1) FR2714670B1 (en)
GB (1) GB2285446B (en)
HR (1) HRP941020A2 (en)
HU (1) HUT75657A (en)
IE (1) IE72517B1 (en)
IL (1) IL112184A (en)
IT (1) IT1283770B1 (en)
LU (1) LU88573A1 (en)
LV (1) LV11632B (en)
NL (1) NL9500010A (en)
NO (1) NO326903B1 (en)
NZ (1) NZ278726A (en)
PT (1) PT101627B (en)
RO (1) RO117110B1 (en)
SG (1) SG47030A1 (en)
SI (1) SI9420079A (en)
SK (1) SK282265B6 (en)
WO (1) WO1995018858A1 (en)

Families Citing this family (50)

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US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0690127B1 (en) * 1994-03-31 1998-08-05 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
AU4658596A (en) 1995-02-03 1996-08-21 G.D. Searle & Co. Novel c-mpl ligands
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA9604382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
KR100436680B1 (en) * 1995-06-07 2004-09-18 글락소 그룹 리미티드 Peptides and Compounds That Bind to a Thrombopoietin Receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
NZ334103A (en) * 1996-08-13 2000-09-29 Zymogenetics Inc an expression vector used to transform or transfect a host cell to make a thrombopoietin polypeptide, the cultured yeast cell thereof and the thrombopoietin polypeptide
AU7589898A (en) * 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (en) * 1998-06-30 2000-01-25 윤재승 A novel human thrombopoietin mutein
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CN1250721C (en) 1998-10-23 2006-04-12 安姆根有限公司 Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity
AR030696A1 (en) 2000-05-25 2003-09-03 Smithkline Beecham Corp Derivatives hydroxy-1-azobenzene, pharmaceutical compositions comprising them, use of these compounds in the manufacture of medicines, a process for preparing such compositions, process for preparing such compounds, or in vitro method for increasing ex vivo stimulation of maturation
UY26317A1 (en) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch System of human thrombopoietin production by mammalian cells in culture
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
WO2003041495A1 (en) 2001-11-15 2003-05-22 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (en) * 2001-11-29 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo activity of erythropoietin
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004026332A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
WO2005023834A2 (en) 2003-08-28 2005-03-17 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to thrombopoietin receptors
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
JP2007537755A (en) 2004-05-18 2007-12-27 イントレクソン コーポレイション The method for dynamic vector construction of Dna cloning vector plasmid
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
CA2658639C (en) 2006-07-24 2015-08-04 The University Of Queensland Method of producing a population of cells of the neutrophil lineage
EP2738257A1 (en) 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2010085086A2 (en) 2009-01-20 2010-07-29 한올바이오파마 주식회사 Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CN103555760B (en) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 Preparation method and preparation of recombinant human thrombopoietin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
AT204606T (en) * 1991-12-06 2001-09-15 Genentech Inc Prohormone convertase transformed cells.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
HRP941020A2 (en) 1997-04-30
WO1995018858A1 (en) 1995-07-13
LV11632B (en) 1997-04-20
GB2285446A (en) 1995-07-12
ES2114786B1 (en) 1999-01-01
RO117110B1 (en) 2001-10-30
IL112184A (en) 2004-07-25
JPH09508262A (en) 1997-08-26
CZ296130B6 (en) 2006-01-11
IT1283770B1 (en) 1998-04-30
IE950002A1 (en) 1995-07-12
IE72517B1 (en) 1997-04-23
LU88573A1 (en) 1995-06-01
GB2285446B (en) 1999-07-28
EP0738323A1 (en) 1996-10-23
AU704266B2 (en) 1999-04-15
FR2714670A1 (en) 1995-07-07
ES2114786A1 (en) 1998-06-01
HU9601805D0 (en) 1996-08-28
SK87596A3 (en) 1997-11-05
FI121573B1 (en)
CN1134539C (en) 2004-01-14
NL9500010A (en) 1995-08-01
AU1514695A (en) 1995-08-01
CZ192296A3 (en) 1997-05-14
IL112184D0 (en) 1995-03-15
CN1141061A (en) 1997-01-22
GB9425831D0 (en) 1995-02-22
FI962723D0 (en)
JPH10113186A (en) 1998-05-06
FI962723A0 (en) 1996-07-02
HUT75657A (en) 1997-05-28
NO962783D0 (en) 1996-07-02
ITTO950002A1 (en) 1995-07-03
PT101627B (en) 1996-11-29
BG63639B1 (en) 2002-07-31
NO326903B1 (en) 2009-03-16
NZ278726A (en) 1998-06-26
FR2714670B1 (en) 1997-01-10
SI9420079A (en) 1997-02-28
PT101627A (en) 1995-11-30
FI962723A (en) 1996-09-03
CA2178482A1 (en) 1995-07-13
NO962783L (en) 1996-09-03
CA2178482C (en) 2012-01-03
SK282265B6 (en) 2001-12-03
FI121573B (en) 2011-01-14
DK149194A (en) 1995-07-04
BG100693A (en) 1998-01-30
ITTO950002D0 (en) 1995-01-02
SG47030A1 (en) 1998-03-20

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