IL112184A0 - Thrombopoietin - Google Patents

Thrombopoietin

Info

Publication number
IL112184A0
IL112184A0 IL11218494A IL11218494A IL112184A0 IL 112184 A0 IL112184 A0 IL 112184A0 IL 11218494 A IL11218494 A IL 11218494A IL 11218494 A IL11218494 A IL 11218494A IL 112184 A0 IL112184 A0 IL 112184A0
Authority
IL
Israel
Prior art keywords
thrombopoietin
Prior art date
Application number
IL11218494A
Other versions
IL112184A (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to IL13933594A priority Critical patent/IL139335A/en
Publication of IL112184A0 publication Critical patent/IL112184A0/en
Priority to IL13933500A priority patent/IL139335A0/en
Publication of IL112184A publication Critical patent/IL112184A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IL11218494A 1994-01-03 1994-12-29 Fusion proteins comprising a mpl ligand and a heterologous polypeptide, nucleic acids encoding such proteins, vectors and host cells comprising such nucleic acid, compositions comprising such fusion proteins and use thereof in the treatment of thrombocytopenia IL112184A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL13933594A IL139335A (en) 1994-01-03 1994-12-29 Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia
IL13933500A IL139335A0 (en) 1994-01-03 2000-10-29 Thrombopoietin

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
IL112184A0 true IL112184A0 (en) 1995-03-15
IL112184A IL112184A (en) 2004-07-25

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11218494A IL112184A (en) 1994-01-03 1994-12-29 Fusion proteins comprising a mpl ligand and a heterologous polypeptide, nucleic acids encoding such proteins, vectors and host cells comprising such nucleic acid, compositions comprising such fusion proteins and use thereof in the treatment of thrombocytopenia

Country Status (28)

Country Link
EP (1) EP0738323A1 (en)
JP (2) JPH09508262A (en)
CN (1) CN1134539C (en)
AU (1) AU704266B2 (en)
BG (1) BG63639B1 (en)
CA (1) CA2178482C (en)
CZ (1) CZ296130B6 (en)
DK (1) DK149194A (en)
ES (1) ES2114786B1 (en)
FI (1) FI121573B (en)
FR (1) FR2714670B1 (en)
GB (1) GB2285446B (en)
HR (1) HRP941020A2 (en)
HU (1) HUT75657A (en)
IE (1) IE72517B1 (en)
IL (1) IL112184A (en)
IT (1) IT1283770B1 (en)
LU (1) LU88573A1 (en)
LV (1) LV11632B (en)
NL (1) NL9500010A (en)
NO (1) NO326903B1 (en)
NZ (1) NZ278726A (en)
PT (1) PT101627B (en)
RO (1) RO117110B1 (en)
SG (1) SG47030A1 (en)
SI (1) SI9420079A (en)
SK (1) SK282265B6 (en)
WO (1) WO1995018858A1 (en)

Families Citing this family (54)

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US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
CA2167090C (en) * 1994-03-31 2002-05-14 Timothy D. Bartley Compositions and methods for stimulating megakaryocyte growth and differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
AU4658596A (en) 1995-02-03 1996-08-21 G.D. Searle & Co. Novel c-mpl ligands
CA2209298C (en) * 1995-02-15 2001-12-18 Amgen Inc. Mpl ligand analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
BR9608587A (en) * 1995-06-07 1999-01-05 Glaxo Group Ltd Compound that binds to the thrombopoietin receptor pharmaceutical composition and process for treating a patient suffering from a disorder
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
CN1230993A (en) * 1996-08-13 1999-10-06 津莫吉尼蒂克斯公司 Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
EP0983082A1 (en) * 1997-05-21 2000-03-08 Genentech, Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (en) * 1998-06-30 2000-01-25 윤재승 A novel human thrombopoietin mutein
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
EP1124961B9 (en) 1998-10-23 2010-07-21 Kirin-Amgen Inc. Thrombopoietic compounds
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (en) * 2000-05-25 2020-05-29 Novartis Ag THROMBOPOIETIN MIMETICS
UY26317A1 (en) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch PRODUCTION SYSTEM OF HUMAN THROMBOPOYETINE BY CELLS OF MAMMALS IN CULTIVATION
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
JP4087338B2 (en) 2001-11-15 2008-05-21 キリンファーマ株式会社 Chimeric non-human animal
KR100467750B1 (en) * 2001-11-29 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo activity of erythropoietin
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004026332A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
CA2537421C (en) 2003-08-28 2011-09-27 Brian R. Macdonald Peptides and compounds that bind to thrombopoietin receptor
EP1751298A4 (en) 2004-05-18 2009-11-11 Intrexon Corp Methods for dynamic vector assembly of dna cloning vector plasmids
US8143380B2 (en) 2004-07-08 2012-03-27 Amgen Inc. Therapeutic peptides
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
CA2658639C (en) 2006-07-24 2015-08-04 The University Of Queensland Method of producing a population of cells of the neutrophil lineage
EP2738257A1 (en) 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
EP2390261A4 (en) 2009-01-20 2012-11-14 Hanall Biopharma Co Ltd Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CN105101979B (en) 2012-12-21 2021-10-08 安斯泰来再生医药协会 Method for preparing platelets from pluripotent stem cells and composition thereof
CN103555760B (en) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 Preparation method and preparation of recombinant human thrombopoietin
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
BR112022005028A2 (en) * 2019-09-20 2022-07-05 Ractigen Therapeutics NUCLEIC ACID MOLECULE FOR THROMBOCYTOPENIA TREATMENT AND USE THEREOF
AU2020408017A1 (en) 2019-12-20 2022-07-14 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
CA2123430C (en) * 1991-12-06 2004-02-10 Cornelia M. Gorman Prohormone convertase transformed cells
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
AU1514695A (en) 1995-08-01
CA2178482C (en) 2012-01-03
PT101627B (en) 1996-11-29
IE72517B1 (en) 1997-04-23
JPH10113186A (en) 1998-05-06
FI962723A (en) 1996-09-03
CZ192296A3 (en) 1997-05-14
AU704266B2 (en) 1999-04-15
SG47030A1 (en) 1998-03-20
LU88573A1 (en) 1995-06-01
FI121573B (en) 2011-01-14
HRP941020A2 (en) 1997-04-30
GB9425831D0 (en) 1995-02-22
NO962783D0 (en) 1996-07-02
NO962783L (en) 1996-09-03
HU9601805D0 (en) 1996-08-28
LV11632A (en) 1996-12-20
SK87596A3 (en) 1997-11-05
ITTO950002A0 (en) 1995-01-02
ES2114786B1 (en) 1999-01-01
DK149194A (en) 1995-07-04
GB2285446B (en) 1999-07-28
LV11632B (en) 1997-04-20
WO1995018858A1 (en) 1995-07-13
SK282265B6 (en) 2001-12-03
IL112184A (en) 2004-07-25
JPH09508262A (en) 1997-08-26
CN1134539C (en) 2004-01-14
BG63639B1 (en) 2002-07-31
GB2285446A (en) 1995-07-12
RO117110B1 (en) 2001-10-30
FR2714670B1 (en) 1997-01-10
NZ278726A (en) 1998-06-26
CA2178482A1 (en) 1995-07-13
ITTO950002A1 (en) 1995-07-03
BG100693A (en) 1998-01-30
ES2114786A1 (en) 1998-06-01
EP0738323A1 (en) 1996-10-23
NO326903B1 (en) 2009-03-16
FR2714670A1 (en) 1995-07-07
SI9420079A (en) 1997-02-28
FI962723A0 (en) 1996-07-02
PT101627A (en) 1995-11-30
IT1283770B1 (en) 1998-04-30
HUT75657A (en) 1997-05-28
CZ296130B6 (en) 2006-01-11
CN1141061A (en) 1997-01-22
IE950002A1 (en) 1995-07-12
NL9500010A (en) 1995-08-01

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