GB9425831D0 - Thrombopoietin - Google Patents

Thrombopoietin

Info

Publication number
GB9425831D0
GB9425831D0 GBGB9425831.6A GB9425831A GB9425831D0 GB 9425831 D0 GB9425831 D0 GB 9425831D0 GB 9425831 A GB9425831 A GB 9425831A GB 9425831 D0 GB9425831 D0 GB 9425831D0
Authority
GB
United Kingdom
Prior art keywords
thrombopoietin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB9425831.6A
Other versions
GB2285446A (en
GB2285446B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of GB9425831D0 publication Critical patent/GB9425831D0/en
Publication of GB2285446A publication Critical patent/GB2285446A/en
Application granted granted Critical
Publication of GB2285446B publication Critical patent/GB2285446B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB9425831A 1994-01-03 1994-12-21 Thrombopoietin Expired - Lifetime GB2285446B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (3)

Publication Number Publication Date
GB9425831D0 true GB9425831D0 (en) 1995-02-22
GB2285446A GB2285446A (en) 1995-07-12
GB2285446B GB2285446B (en) 1999-07-28

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9425831A Expired - Lifetime GB2285446B (en) 1994-01-03 1994-12-21 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (en)
JP (2) JPH09508262A (en)
CN (1) CN1134539C (en)
AU (1) AU704266B2 (en)
BG (1) BG63639B1 (en)
CA (1) CA2178482C (en)
CZ (1) CZ296130B6 (en)
DK (1) DK149194A (en)
ES (1) ES2114786B1 (en)
FI (1) FI121573B (en)
FR (1) FR2714670B1 (en)
GB (1) GB2285446B (en)
HR (1) HRP941020A2 (en)
HU (1) HUT75657A (en)
IE (1) IE72517B1 (en)
IL (1) IL112184A (en)
IT (1) IT1283770B1 (en)
LU (1) LU88573A1 (en)
LV (1) LV11632B (en)
NL (1) NL9500010A (en)
NO (1) NO326903B1 (en)
NZ (1) NZ278726A (en)
PT (1) PT101627B (en)
RO (1) RO117110B1 (en)
SG (1) SG47030A1 (en)
SI (1) SI9420079A (en)
SK (1) SK282265B6 (en)
WO (1) WO1995018858A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5766581A (en) * 1994-03-31 1998-06-16 Amgen Inc. Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
AU4658596A (en) 1995-02-03 1996-08-21 G.D. Searle & Co. Novel c-mpl ligands
US5696250A (en) 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
WO1996025498A2 (en) * 1995-02-15 1996-08-22 Amgen Inc. Mpl ligand analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
DK0885242T3 (en) * 1995-06-07 2008-07-14 Glaxo Group Ltd Peptides and compounds that bind to a thrombopoietin receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
WO1998006849A1 (en) * 1996-08-13 1998-02-19 Zymogenetics, Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
JP4562815B2 (en) * 1997-05-21 2010-10-13 ジェネンテック， インコーポレイテッド New administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (en) * 1998-06-30 2000-01-25 윤재승 A novel human thrombopoietin mutein
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
CN1810832B (en) 1998-10-23 2012-12-12 麒麟-安姆根有限公司 Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (en) * 2000-05-25 2020-05-29 Novartis Ag THROMBOPOIETIN MIMETICS
UY26317A1 (en) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch PRODUCTION SYSTEM OF HUMAN THROMBOPOYETINE BY CELLS OF MAMMALS IN CULTIVATION
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20050177884A1 (en) 2001-11-15 2005-08-11 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (en) * 2001-11-29 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo activity of erythropoietin
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
CA2499625A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
MXPA06002292A (en) 2003-08-28 2006-09-04 Johnson & Johnson Peptides and compounds that bind to thrombopoietin receptors.
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
WO2005116231A1 (en) 2004-05-18 2005-12-08 Intrexon Corporation Methods for dynamic vector assembly of dna cloning vector plasmids
MX2007000216A (en) 2004-07-08 2007-03-15 Amgen Inc Therapeutic peptides.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
MX2009012609A (en) 2007-05-22 2009-12-07 Amgen Inc Compositions and methods for producing bioactive fusion proteins.
US20110294733A1 (en) 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
EP2934555B1 (en) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells
CN103555760B (en) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 Preparation method and preparation of recombinant human thrombopoietin
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
JP2022552940A (en) * 2019-09-20 2022-12-21 ラクティゲン セラピューティクス Nucleic acid molecule for treating thrombocytopenia and its application
EP4077641A1 (en) 2019-12-20 2022-10-26 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
PT616645E (en) * 1991-12-06 2002-02-28 Genentech Inc TRANSFORMED CELLS FOR PROHORMONE CONVERTASE
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
ITTO950002A0 (en) 1995-01-02
SK282265B6 (en) 2001-12-03
JPH09508262A (en) 1997-08-26
HU9601805D0 (en) 1996-08-28
FI962723A (en) 1996-09-03
CZ192296A3 (en) 1997-05-14
JPH10113186A (en) 1998-05-06
ES2114786A1 (en) 1998-06-01
NO962783D0 (en) 1996-07-02
BG63639B1 (en) 2002-07-31
IE950002A1 (en) 1995-07-12
AU1514695A (en) 1995-08-01
FI121573B (en) 2011-01-14
CN1134539C (en) 2004-01-14
WO1995018858A1 (en) 1995-07-13
IL112184A0 (en) 1995-03-15
IT1283770B1 (en) 1998-04-30
FR2714670B1 (en) 1997-01-10
PT101627B (en) 1996-11-29
SI9420079A (en) 1997-02-28
DK149194A (en) 1995-07-04
IL112184A (en) 2004-07-25
LV11632B (en) 1997-04-20
BG100693A (en) 1998-01-30
LV11632A (en) 1996-12-20
HRP941020A2 (en) 1997-04-30
IE72517B1 (en) 1997-04-23
GB2285446A (en) 1995-07-12
ITTO950002A1 (en) 1995-07-03
EP0738323A1 (en) 1996-10-23
NL9500010A (en) 1995-08-01
GB2285446B (en) 1999-07-28
CA2178482A1 (en) 1995-07-13
SG47030A1 (en) 1998-03-20
FI962723A0 (en) 1996-07-02
CN1141061A (en) 1997-01-22
SK87596A3 (en) 1997-11-05
LU88573A1 (en) 1995-06-01
FR2714670A1 (en) 1995-07-07
CA2178482C (en) 2012-01-03
CZ296130B6 (en) 2006-01-11
HUT75657A (en) 1997-05-28
RO117110B1 (en) 2001-10-30
NO962783L (en) 1996-09-03
NZ278726A (en) 1998-06-26
NO326903B1 (en) 2009-03-16
AU704266B2 (en) 1999-04-15
PT101627A (en) 1995-11-30
ES2114786B1 (en) 1999-01-01

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20141220