CA2178482C - Thrombopoietin - Google Patents
Thrombopoietin Download PDFInfo
- Publication number
- CA2178482C CA2178482C CA2178482A CA2178482A CA2178482C CA 2178482 C CA2178482 C CA 2178482C CA 2178482 A CA2178482 A CA 2178482A CA 2178482 A CA2178482 A CA 2178482A CA 2178482 C CA2178482 C CA 2178482C
- Authority
- CA
- Canada
- Prior art keywords
- mpl ligand
- mpl
- cells
- ligand
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17655394A | 1994-01-03 | 1994-01-03 | |
US08/176553 | 1994-01-03 | ||
US18560794A | 1994-01-21 | 1994-01-21 | |
US08/185607 | 1994-01-21 | ||
US08/196,689 US8357513B1 (en) | 1994-01-03 | 1994-02-15 | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
US08/196689 | 1994-02-15 | ||
US22326394A | 1994-04-04 | 1994-04-04 | |
US08/223263 | 1994-04-04 | ||
US08/249,376 US8192955B1 (en) | 1994-01-03 | 1994-05-25 | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
US08/249376 | 1994-05-25 | ||
US34865894A | 1994-12-02 | 1994-12-02 | |
US08/348,657 US6660256B1 (en) | 1994-01-03 | 1994-12-02 | Porcine mpl ligand |
US08/348658 | 1994-12-02 | ||
US08/348657 | 1994-12-02 | ||
PCT/US1994/014553 WO1995018858A1 (en) | 1994-01-03 | 1994-12-28 | Thrombopoietin |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2178482A1 CA2178482A1 (en) | 1995-07-13 |
CA2178482C true CA2178482C (en) | 2012-01-03 |
Family
ID=27569151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2178482A Expired - Lifetime CA2178482C (en) | 1994-01-03 | 1994-12-28 | Thrombopoietin |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0738323A1 (lv) |
JP (2) | JPH09508262A (lv) |
CN (1) | CN1134539C (lv) |
AU (1) | AU704266B2 (lv) |
BG (1) | BG63639B1 (lv) |
CA (1) | CA2178482C (lv) |
CZ (1) | CZ296130B6 (lv) |
DK (1) | DK149194A (lv) |
ES (1) | ES2114786B1 (lv) |
FI (1) | FI121573B (lv) |
FR (1) | FR2714670B1 (lv) |
GB (1) | GB2285446B (lv) |
HR (1) | HRP941020A2 (lv) |
HU (1) | HUT75657A (lv) |
IE (1) | IE72517B1 (lv) |
IL (1) | IL112184A (lv) |
IT (1) | IT1283770B1 (lv) |
LU (1) | LU88573A1 (lv) |
LV (1) | LV11632B (lv) |
NL (1) | NL9500010A (lv) |
NO (1) | NO326903B1 (lv) |
NZ (1) | NZ278726A (lv) |
PT (1) | PT101627B (lv) |
RO (1) | RO117110B1 (lv) |
SG (1) | SG47030A1 (lv) |
SI (1) | SI9420079A (lv) |
SK (1) | SK282265B6 (lv) |
WO (1) | WO1995018858A1 (lv) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
CA2167090C (en) * | 1994-03-31 | 2002-05-14 | Timothy D. Bartley | Compositions and methods for stimulating megakaryocyte growth and differentiation |
US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
TW387940B (en) * | 1995-01-17 | 2000-04-21 | Kirin Brewery | Anti-tpo monodonal antibody |
AU4658596A (en) | 1995-02-03 | 1996-08-21 | G.D. Searle & Co. | Novel c-mpl ligands |
CA2209298C (en) * | 1995-02-15 | 2001-12-18 | Amgen Inc. | Mpl ligand analogs |
US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
US5696250A (en) * | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
ZA964382B (en) * | 1995-06-06 | 1997-12-01 | Genentech Inc | Lymphotoxin and thrombopoietin for use in the treatment of cancer. |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
BR9608587A (pt) * | 1995-06-07 | 1999-01-05 | Glaxo Group Ltd | Composto que se liga ao receptor de trombopoietina composição farmacêutica e processo para o tratamento de um paciente sofrendo de um distúrbio |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
CN1230993A (zh) * | 1996-08-13 | 1999-10-06 | 津莫吉尼蒂克斯公司 | 制备血小板生成素多肽的表达载体、细胞和方法 |
EP0983082A1 (en) * | 1997-05-21 | 2000-03-08 | Genentech, Inc. | Novel administration of thrombopoietin |
US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
KR20000006549A (ko) * | 1998-06-30 | 2000-01-25 | 윤재승 | 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체 |
US20030228666A1 (en) | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
EP1124961B9 (en) | 1998-10-23 | 2010-07-21 | Kirin-Amgen Inc. | Thrombopoietic compounds |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
JP4087338B2 (ja) | 2001-11-15 | 2008-05-21 | キリンファーマ株式会社 | キメラ非ヒト動物 |
KR100467750B1 (ko) * | 2001-11-29 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
WO2004026332A1 (en) | 2002-09-18 | 2004-04-01 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
CA2537421C (en) | 2003-08-28 | 2011-09-27 | Brian R. Macdonald | Peptides and compounds that bind to thrombopoietin receptor |
EP1751298A4 (en) | 2004-05-18 | 2009-11-11 | Intrexon Corp | METHOD FOR DYNAMIC VECTOR ASSEMBLY OF DNA CLONING VECTOR PLASMIDES |
US8143380B2 (en) | 2004-07-08 | 2012-03-27 | Amgen Inc. | Therapeutic peptides |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
WO2007098547A1 (en) * | 2006-03-01 | 2007-09-07 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
CA2658639C (en) | 2006-07-24 | 2015-08-04 | The University Of Queensland | Method of producing a population of cells of the neutrophil lineage |
EP2738257A1 (en) | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
EP2390261A4 (en) | 2009-01-20 | 2012-11-14 | Hanall Biopharma Co Ltd | MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND METHOD FOR THE PRODUCTION THEREOF |
WO2014089478A1 (en) * | 2012-12-07 | 2014-06-12 | University Of Tennessee Research Foundation | Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same |
CN105101979B (zh) | 2012-12-21 | 2021-10-08 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
CN103555760B (zh) * | 2013-10-18 | 2015-05-20 | 江苏康禾生物制药有限公司 | 一种重组人血小板生成素的制备方法及其制剂 |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
BR112022005028A2 (pt) * | 2019-09-20 | 2022-07-05 | Ractigen Therapeutics | Molécula de ácido nucleico para tratamento de trombocitopenia e uso da mesma |
AU2020408017A1 (en) | 2019-12-20 | 2022-07-14 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260417A (en) | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
CA2123430C (en) * | 1991-12-06 | 2004-02-10 | Cornelia M. Gorman | Prohormone convertase transformed cells |
IL139335A (en) | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
-
1994
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en active IP Right Grant
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
- 1994-12-30 ES ES09402681A patent/ES2114786B1/es not_active Expired - Fee Related
- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
-
1995
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
-
1996
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
-
1997
- 1997-03-27 JP JP9074906A patent/JPH10113186A/ja active Pending
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20141229 |