ES2114786B1 - Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion. - Google Patents

Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion.

Info

Publication number
ES2114786B1
ES2114786B1 ES09402681A ES9402681A ES2114786B1 ES 2114786 B1 ES2114786 B1 ES 2114786B1 ES 09402681 A ES09402681 A ES 09402681A ES 9402681 A ES9402681 A ES 9402681A ES 2114786 B1 ES2114786 B1 ES 2114786B1
Authority
ES
Spain
Prior art keywords
thrombopoyetine
recombinant
procedure
obtaining
tpo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09402681A
Other languages
English (en)
Other versions
ES2114786A1 (es
Inventor
Dan L Eaton
Sauvage Frederic J De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES2114786A1 publication Critical patent/ES2114786A1/es
Application granted granted Critical
Publication of ES2114786B1 publication Critical patent/ES2114786B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

TROMBOPOYETINA RECOMBINANTE Y PROCEDIMIENTO DE OBTENCION. SE DESCRIBEN TROMBOPOYETINA (TPO) AISLADA, DNA AISLADO QUE CODIFICA TPO, Y METODOS RECOMBINANTES O SINTETICOS DE PREPARACION Y PURIFICACION DE TPO. SE MUESTRAN DIVERSAS FORMAS DE TPO QUE INFLUYEN EN LA REPLICACION, DIFERENCIACION O MADURACION DE LAS CELULAS SANGUINEAS, ESPECIALMENTE LOS MEGARIOCITOS Y CELULAS PROGENITORAS DE MEGARIOCITOS. DE ACUERDO CON ELLO, ESTOS COMPUESTOS SE PUEDEN UTILIZAR PARA EL TRATAMIENTO DE LA TROMBOCITOPENIA.
ES09402681A 1994-01-03 1994-12-30 Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion. Expired - Fee Related ES2114786B1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
ES2114786A1 ES2114786A1 (es) 1998-06-01
ES2114786B1 true ES2114786B1 (es) 1999-01-01

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09402681A Expired - Fee Related ES2114786B1 (es) 1994-01-03 1994-12-30 Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion.

Country Status (28)

Country Link
EP (1) EP0738323A1 (es)
JP (2) JPH09508262A (es)
CN (1) CN1134539C (es)
AU (1) AU704266B2 (es)
BG (1) BG63639B1 (es)
CA (1) CA2178482C (es)
CZ (1) CZ296130B6 (es)
DK (1) DK149194A (es)
ES (1) ES2114786B1 (es)
FI (1) FI121573B (es)
FR (1) FR2714670B1 (es)
GB (1) GB2285446B (es)
HR (1) HRP941020A2 (es)
HU (1) HUT75657A (es)
IE (1) IE72517B1 (es)
IL (1) IL112184A (es)
IT (1) IT1283770B1 (es)
LU (1) LU88573A1 (es)
LV (1) LV11632B (es)
NL (1) NL9500010A (es)
NO (1) NO326903B1 (es)
NZ (1) NZ278726A (es)
PT (1) PT101627B (es)
RO (1) RO117110B1 (es)
SG (1) SG47030A1 (es)
SI (1) SI9420079A (es)
SK (1) SK282265B6 (es)
WO (1) WO1995018858A1 (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
AU691828B2 (en) * 1994-02-14 1998-05-28 University Of Washington Hematopoietic protein and materials and methods for making it
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5766581A (en) * 1994-03-31 1998-06-16 Amgen Inc. Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
ES2303338T3 (es) * 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
CA2288964A1 (en) * 1997-05-21 1998-11-26 Genentech, Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
DK2319928T3 (da) 1998-10-23 2013-06-24 Kirin Amgen Inc Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
JP4087338B2 (ja) 2001-11-15 2008-05-21 キリンファーマ株式会社 キメラ非ヒト動物
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
RS56387B1 (sr) 2003-08-28 2017-12-29 Ortho Mcneil Pharm Inc Peptidi i jedinjenja koja se vežu za trombopoetinski receptor
EP1751298A4 (en) 2004-05-18 2009-11-11 Intrexon Corp METHOD FOR DYNAMIC VECTOR ASSEMBLY OF DNA CLONING VECTOR PLASMIDES
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
CN101103045B (zh) 2004-09-24 2015-11-25 安姆根有限公司 修饰的Fc分子
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
JP5543778B2 (ja) 2006-07-24 2014-07-09 ザ・ユニバーシティ・オブ・クイーンズランド 細胞集団を産生する方法
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
JP5591691B2 (ja) 2007-05-22 2014-09-17 アムジエン・インコーポレーテツド 生物活性を有する融合タンパク質を作製するための組成物及び方法
WO2010085086A2 (ko) 2009-01-20 2010-07-29 한올바이오파마 주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
SG11201804902UA (en) * 2015-12-21 2018-07-30 Brainon Inc A composition for improving memory, learning ability, and cognitive ability
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2020349991A1 (en) * 2019-09-20 2022-04-07 Ractigen Therapeutics Nucleic acid molecule for treating immune thrombocytopenia and application thereof
CN115244173A (zh) 2019-12-20 2022-10-25 英研生物(英国)有限公司 用于分离肿瘤浸润淋巴细胞的装置及方法及其用途
CN118086536A (zh) * 2024-04-23 2024-05-28 佛山科学技术学院 一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
DE69232017T2 (de) * 1991-12-06 2002-03-21 Genentech, Inc. Prohormon Konvertase transformierte Zellen.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
LV11632B (en) 1997-04-20
IT1283770B1 (it) 1998-04-30
CN1134539C (zh) 2004-01-14
GB2285446B (en) 1999-07-28
HUT75657A (en) 1997-05-28
EP0738323A1 (en) 1996-10-23
FI962723L (fi) 1996-09-03
HRP941020A2 (en) 1997-04-30
RO117110B1 (ro) 2001-10-30
CZ192296A3 (en) 1997-05-14
SK87596A3 (en) 1997-11-05
NO962783L (no) 1996-09-03
LU88573A1 (de) 1995-06-01
CZ296130B6 (cs) 2006-01-11
SG47030A1 (en) 1998-03-20
CA2178482A1 (en) 1995-07-13
DK149194A (da) 1995-07-04
GB2285446A (en) 1995-07-12
FI962723A0 (fi) 1996-07-02
CA2178482C (en) 2012-01-03
CN1141061A (zh) 1997-01-22
NL9500010A (nl) 1995-08-01
SI9420079A (en) 1997-02-28
FR2714670B1 (fr) 1997-01-10
LV11632A (lv) 1996-12-20
IL112184A (en) 2004-07-25
BG100693A (en) 1998-01-30
FI121573B (fi) 2011-01-14
AU1514695A (en) 1995-08-01
ITTO950002A1 (it) 1996-07-02
IL112184A0 (en) 1995-03-15
NO962783D0 (no) 1996-07-02
FR2714670A1 (fr) 1995-07-07
ES2114786A1 (es) 1998-06-01
PT101627A (pt) 1995-11-30
ITTO950002A0 (it) 1995-01-02
GB9425831D0 (en) 1995-02-22
NZ278726A (en) 1998-06-26
SK282265B6 (sk) 2001-12-03
WO1995018858A1 (en) 1995-07-13
HU9601805D0 (en) 1996-08-28
JPH09508262A (ja) 1997-08-26
IE950002A1 (en) 1995-07-12
AU704266B2 (en) 1999-04-15
NO326903B1 (no) 2009-03-16
BG63639B1 (bg) 2002-07-31
JPH10113186A (ja) 1998-05-06
PT101627B (pt) 1996-11-29
IE72517B1 (en) 1997-04-23

Similar Documents

Publication Publication Date Title
ES2114786B1 (es) Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion.
ES2047106T3 (es) Procedimiento para la purificacion de glicerina bruta.
ES2142953T3 (es) Factor de crecimiento y diferenciacion de la familia del tgf-beta.
TR200100056T2 (tr) Nörotrofik faktörler
ES2174895T3 (es) Combinaciones metalicas complejas con contenido en carbenos heterociclicos.
ES2053719T3 (es) Dimetilvermectinas no naturales y procedimiento para su preparacion.
DE69433742D1 (de) Bmp-10 zusammensetzungen
DK0765327T3 (da) Pyrazolo- og pyrrolopyridiner
PT804196E (pt) Utilizacao de antagonistas de serotonina (5ht3) para o tratamento de fibromialgia
DE69427848D1 (de) Unterstützungssystem zur Herstellung von Wörterbüchern
ATE116848T1 (de) Verwendung von baclofen zur herstellung von arzneimitteln zur behandlung von angina pectoris.
ES2151607T3 (es) Factor 12 de crecimiento y de diferenciacion.
FI962247L (fi) Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden käyttömenetelmät
ES8608885A1 (es) Procedimiento para distinguir celulas normales de malignas, en una mezcla de las mismas
FI945221L (fi) Yhdistelmä-DNA-molekyylejä, jotka koodittavat aminopeptidaasientsyymejä, ja niiden käyttö rokotteiden valmistamiseksi matotartuntoja vastaan
PT809437E (pt) Tiois para promover crescimento de celulas progenitoras hematopoieticas
ES8603950A1 (es) Un procedimiento para inactivar un virus asociado a un material biologico
ES2070855T3 (es) Metodo para purificar una proteina.
ATE81776T1 (de) Verwendung von chinolon und naphthyridinantibiotika zur herstellung von ophthalmischen arzneimitteln.
IT9047976A0 (it) Procedimento ed impianto per la depurazione biologica delle acque reflue.
ES2054612T3 (es) Secuencias de adn que codifican para proteinas con actividad biologica de los inhibidores husi tipo-i y procedimientos tecnologicos geneticos para la preparacion de estas proteinas.
MX9302279A (es) Metodo para la produccion del factor viii presenteen el plasma, altamente purificado.
DE69010294D1 (de) Verwendung von Antiprogestomimetika zur Stimulierung des Eisprungs.
ES2098316T3 (es) Procedimiento de purificacion de carrageninas comerciales.
MX9302951A (es) Composicion farmaceutica para tratar la hiperproliferacion celular.

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19980601

Kind code of ref document: A1

Effective date: 19980601

FD2A Announcement of lapse in spain

Effective date: 20150826