MX9302279A - Metodo para la produccion del factor viii presenteen el plasma, altamente purificado. - Google Patents
Metodo para la produccion del factor viii presenteen el plasma, altamente purificado.Info
- Publication number
- MX9302279A MX9302279A MX9302279A MX9302279A MX9302279A MX 9302279 A MX9302279 A MX 9302279A MX 9302279 A MX9302279 A MX 9302279A MX 9302279 A MX9302279 A MX 9302279A MX 9302279 A MX9302279 A MX 9302279A
- Authority
- MX
- Mexico
- Prior art keywords
- factor viii
- highly purified
- plasma
- production
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se relaciona con un método para la producción del factor VII altamente purificado de virus. El método incluye una combinación de las siguientes mediciones: a) purificación cromatográfica de una fracción que contiene el factor VIII; b) tratamiento con tensida del factor VIII en solución acuosa en una relación tensida/proteína de 1:1 a 1000:1, y c) tratamiento térmico de la preparación de factor VIII en el estado sólido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0084992A AT399818B (de) | 1992-04-24 | 1992-04-24 | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9302279A true MX9302279A (es) | 1994-08-31 |
Family
ID=3501200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9302279A MX9302279A (es) | 1992-04-24 | 1993-04-20 | Metodo para la produccion del factor viii presenteen el plasma, altamente purificado. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5410022A (es) |
EP (1) | EP0567448B2 (es) |
JP (1) | JP2511631B2 (es) |
AT (2) | AT399818B (es) |
AU (1) | AU659301B2 (es) |
BR (1) | BR9301641A (es) |
CA (1) | CA2094347C (es) |
CZ (1) | CZ279979B6 (es) |
DE (1) | DE59308628D1 (es) |
DK (1) | DK0567448T4 (es) |
ES (1) | ES2117703T5 (es) |
FI (1) | FI106468B (es) |
HU (1) | HU210632B (es) |
MX (1) | MX9302279A (es) |
NO (1) | NO307465B1 (es) |
PL (1) | PL172462B1 (es) |
SK (1) | SK279750B6 (es) |
ZA (1) | ZA932843B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0674531A1 (de) * | 1992-12-16 | 1995-10-04 | IMMUNO Aktiengesellschaft | Verfahren zur herstellung eines virussicheren biologischen präparates |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
DE4325872C1 (de) * | 1993-08-02 | 1994-08-04 | Immuno Ag | Virusinaktivierte Faktor Xa-Präparation |
AT402788B (de) * | 1993-08-03 | 1997-08-25 | Immuno Ag | Virussichere blutgerinnungsfaktor xiii-präparation |
DE4337573C1 (de) * | 1993-11-04 | 1995-05-18 | Octapharma Ag | Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden |
DE4407837C1 (de) * | 1994-03-09 | 1995-08-17 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
DE19623293C2 (de) * | 1996-06-11 | 1998-10-22 | Biotest Pharma Gmbh | Nicht-immunogene Faktor VIII-enthaltende Zusammensetzung und ein Verfahren zu ihrer Herstellung |
AT404358B (de) | 1997-02-04 | 1998-11-25 | Immuno Ag | Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial |
PL198123B1 (pl) * | 1999-02-22 | 2008-05-30 | Baxter Int | Kompozycja czynnika VIII bez dodatku albuminy i jej zastosowanie |
US20040117862A1 (en) * | 2002-03-11 | 2004-06-17 | Cooper Julian D. | Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses |
US20060110788A1 (en) * | 2004-10-01 | 2006-05-25 | Invitrogen Corporation | Feeding buffers, systems, and methods for in vitro synthesis of biomolecules |
CA2742328C (en) | 2008-11-07 | 2019-02-26 | Baxter International Inc. | Factor viii formulations |
CN101967188B (zh) * | 2010-11-08 | 2012-11-28 | 江西博雅生物制药股份有限公司 | 一种人凝血因子ⅷ的制备工艺 |
MX2017005941A (es) * | 2014-11-05 | 2018-02-13 | Abbott Laboratories Gmbh | Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos. |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US3920625A (en) * | 1973-06-19 | 1975-11-18 | Kabi Ab | Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates |
AT350726B (de) * | 1976-08-30 | 1979-06-11 | Immuno Ag | Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma |
FR2435832A1 (fr) * | 1978-07-21 | 1980-04-04 | Alsthom Cgee | Dispositif de connexion electrique |
US4250139A (en) * | 1979-02-01 | 1981-02-10 | Collagen Corporation | Microwave sterilization of dry protein |
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
DE3176491D1 (en) * | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
DE3173208D1 (en) * | 1980-10-06 | 1986-01-23 | Edward Shanbrom | Method of reducing undesirable activities of biological and pharmaceutical products |
US4314997A (en) * | 1980-10-06 | 1982-02-09 | Edward Shanbrom | Purification of plasma protein products |
DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
US4481189A (en) * | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
US4379085A (en) * | 1982-05-14 | 1983-04-05 | American National Red Cross | Heat stabilization of plasma proteins |
US4511556A (en) * | 1982-06-10 | 1985-04-16 | The United States Of America As Represented By The Department Of Health And Human Services | Inactivation of a lipid virus |
JPS59134730A (ja) * | 1983-01-20 | 1984-08-02 | Green Cross Corp:The | 血液凝固第8因子の加熱処理法 |
CA1213827A (en) * | 1983-04-29 | 1986-11-12 | Ricardo H. Landaburu | Process for pasteurizing fibronectin |
DE3473407D1 (en) * | 1983-05-02 | 1988-09-22 | Immuno Ag | Method of inactivating pathogens |
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
JPS6054287B2 (ja) * | 1983-10-19 | 1985-11-29 | 株式会社ミドリ十字 | 血漿蛋白の加熱処理方法 |
US4490361A (en) * | 1983-12-02 | 1984-12-25 | Alpha Therapeutic Corporation | Virus inactivating heat treatment of plasma fractions |
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US5043428A (en) * | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
DE3432083A1 (de) * | 1984-08-31 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
JPH0825902B2 (ja) * | 1985-02-21 | 1996-03-13 | 株式会社ミドリ十字 | γ−グロブリンの加熱処理方法 |
US4673733A (en) * | 1985-04-11 | 1987-06-16 | Sudhish Chandra | Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
AT388501B (de) * | 1987-02-12 | 1989-07-25 | Immuno Ag | Verfahren zur herstellung von parenteral verabreichbaren blutprodukten |
EP0413687A1 (en) * | 1987-05-15 | 1991-02-27 | Alan I. Rubinstein | Sequential improved method for treatment of human blood-clotting factor products |
IL86417A (en) * | 1987-05-22 | 1992-09-06 | Armour Pharma | Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers |
AT391809B (de) * | 1988-01-12 | 1990-12-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutplasmaprodukten |
FR2630115B1 (fr) * | 1988-04-14 | 1994-10-28 | Merieux Inst | Procede de stabilisation des solutions d'albumine humaine et solution obtenue |
DE3878227D1 (de) * | 1988-05-27 | 1993-03-18 | Centre Regional De Transfusion | Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie. |
AT397203B (de) * | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
AT390801B (de) * | 1988-07-28 | 1990-07-10 | Immuno Ag | Verfahren zur herstellung von lys-plasminogen |
ATE85221T1 (de) * | 1988-11-05 | 1993-02-15 | Octapharma Ag | Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie. |
US5156973A (en) * | 1988-11-23 | 1992-10-20 | Edward Shanbrom | Antiviral blood sampling process and apparatus |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
ES2057191T5 (es) * | 1989-01-13 | 2003-05-01 | Mitsubishi Pharma Corp | Metodo de produccion para una composicion que contiene proteinas. |
ATE138575T1 (de) * | 1989-06-15 | 1996-06-15 | Rorer Int Overseas | Verfahren zur inaktivierung von viren in mit viren verunreinigten pharmazeutischen zusammensetzungen |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
US5217737A (en) * | 1991-05-20 | 1993-06-08 | Abbott Laboratories | Plastic containers capable of surviving sterilization |
AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
FR2681867B1 (fr) * | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
FR2841484B1 (fr) * | 2002-06-26 | 2004-09-10 | Boucq De Beaudignies Ghisla Le | Dispositif et procede de filtration de l'air et des gaz avec regeneration des particules captees |
-
1992
- 1992-04-24 AT AT0084992A patent/AT399818B/de not_active IP Right Cessation
-
1993
- 1993-04-07 DE DE59308628T patent/DE59308628D1/de not_active Expired - Lifetime
- 1993-04-07 AT AT93890076T patent/ATE166881T1/de not_active IP Right Cessation
- 1993-04-07 DK DK93890076T patent/DK0567448T4/da active
- 1993-04-07 EP EP93890076A patent/EP0567448B2/de not_active Expired - Lifetime
- 1993-04-07 ES ES93890076T patent/ES2117703T5/es not_active Expired - Lifetime
- 1993-04-09 HU HU9301038A patent/HU210632B/hu not_active IP Right Cessation
- 1993-04-14 AU AU36875/93A patent/AU659301B2/en not_active Ceased
- 1993-04-19 CA CA002094347A patent/CA2094347C/en not_active Expired - Fee Related
- 1993-04-20 MX MX9302279A patent/MX9302279A/es not_active IP Right Cessation
- 1993-04-20 US US08/049,585 patent/US5410022A/en not_active Expired - Lifetime
- 1993-04-21 CZ CZ93692A patent/CZ279979B6/cs not_active IP Right Cessation
- 1993-04-22 FI FI931826A patent/FI106468B/fi active
- 1993-04-22 ZA ZA932843A patent/ZA932843B/xx unknown
- 1993-04-22 NO NO931476A patent/NO307465B1/no not_active IP Right Cessation
- 1993-04-22 PL PL93298670A patent/PL172462B1/pl unknown
- 1993-04-23 SK SK391-93A patent/SK279750B6/sk unknown
- 1993-04-23 JP JP5097532A patent/JP2511631B2/ja not_active Expired - Fee Related
- 1993-04-23 BR BR9301641A patent/BR9301641A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SK39193A3 (en) | 1993-11-10 |
HU9301038D0 (en) | 1993-06-28 |
AU3687593A (en) | 1993-10-28 |
DK0567448T3 (da) | 1999-03-22 |
SK279750B6 (sk) | 1999-03-12 |
CA2094347A1 (en) | 1993-10-25 |
CA2094347C (en) | 2002-06-25 |
US5410022A (en) | 1995-04-25 |
HU210632B (en) | 1995-06-28 |
CZ69293A3 (en) | 1993-12-15 |
NO931476L (no) | 1993-10-25 |
PL172462B1 (pl) | 1997-09-30 |
ATE166881T1 (de) | 1998-06-15 |
ZA932843B (en) | 1993-11-23 |
JP2511631B2 (ja) | 1996-07-03 |
ES2117703T5 (es) | 2005-07-16 |
EP0567448B1 (de) | 1998-06-03 |
JPH069694A (ja) | 1994-01-18 |
AT399818B (de) | 1995-07-25 |
NO307465B1 (no) | 2000-04-10 |
PL298670A1 (en) | 1994-04-05 |
BR9301641A (pt) | 1993-10-26 |
HUT64777A (en) | 1994-02-28 |
ES2117703T3 (es) | 1998-08-16 |
NO931476D0 (no) | 1993-04-22 |
EP0567448B2 (de) | 2005-01-05 |
AU659301B2 (en) | 1995-05-11 |
FI106468B (fi) | 2001-02-15 |
DK0567448T4 (da) | 2005-05-02 |
FI931826A0 (fi) | 1993-04-22 |
EP0567448A1 (de) | 1993-10-27 |
CZ279979B6 (cs) | 1995-09-13 |
FI931826A (fi) | 1993-10-25 |
ATA84992A (de) | 1994-12-15 |
DE59308628D1 (de) | 1998-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |